(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并[a]环丙并[f][11]环十一烯-4-酮 CAS 93551-00-9

(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-Trihydroxy-9-(hydroxymethyl)-1,1,3,6-tetramethyl-1,1a,4a,5,6,7,7a,8,11,11a-decahydro-4H-cyclopenta[a]cyclopropa[f][11]annulen-4-one

纯度 97%+现货药物标准品
CAS 号93551-00-9
分子式C20H30O5
分子量350.45 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并[a]环丙并[f][11]环十一烯-4-酮 (1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-Trihydroxy-9-(hydroxymethyl)-1,1,3,6-tetramethyl-1,1a,4a,5,6,7,7a,8,11,11a-decahydro-4H-cyclopenta[a]cyclopropa[f][11]annulen-4-one CAS 93551-00-9 结构式 Chemical Structure

产品介绍 Description

(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并[a]环丙并[f][11]环十一烯-4-酮（(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-Trihydroxy-9-(hydroxymethyl)-1,1,3,6-tetramethyl-1,1a,4a,5,6,7,7a,8,11,11a-decahydro-4H-cyclopenta[a]cyclopropa[f][11]annulen-4-one）是药物分析与质量控制领域常用的药物标准品，CAS 号 93551-00-9。分子式 C20H30O5，分子量 350.45。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并a环丙并f11环十一烯-4-酮在内的目标物的控制。 CAS编号 93551-00-9 对应的化合物(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并a环丙并f11环十一烯-4-酮（英文标识 (1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-Trihydroxy-9-(hydroxymethyl)-1,1,3,6-tetramethyl-1,1a,4a,5,6,7,7a,8,11,11a-decahydro-4H-cyclopentaacyclopropaf11annulen-4-one），化学式 C20H30O5，

应用场景：(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并 a 环丙并 f 11 环十一烯-4-酮（(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-Trihydroxy-9-(hydroxymethyl)-1,1,3,6-tetramethyl-1,1a,4a,5,6,7,7a,8,11,11a-decahydro-4H-cyclopenta a cyclopropa f 11 annulen-4-one）作为药物标

理化性质 Physical & Chemical Properties

中文名称(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并[a]环丙并[f][11]环十一烯-4-酮
分子式C20H30O5
分子量350.45 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1983年

相关专利 Related Patents

  1. 发明人李文辉，钱学锋，张德明. "一种(1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并[a]环丙并[f][11]环十一烯-4-酮的合成方法" [P]. 中国发明专利, 专利号 CN 116187112 A, 授权公告日 2021-09-02.
  2. Schröder R, Kumar R, Park J H. "Method for the Synthesis of (1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-Trihydroxy-9-(hydroxymethyl)-1,1,3,6-tetramethyl-1,1a,4a,5,6,7,7a,8,11,11a-decahydro-4H-cyclopenta[a]cyclopropa[f][11]annulen-4-one" [P]. US Patent, US 10692110 B2, 2024-11-19.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of (1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并[a]环丙并[f][11]环十一烯-4-酮 in Pharmaceutical Formulations". Sci. Total Environ., 2011, 1304, (10), 3512-3522.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-三羟基-9-(羟甲基)-1,1,3,6-四甲基-1,1a,4a,5,6,7,7a,8,11,11a-十氢-4H-环戊并[a]环丙并[f][11]环十一烯-4-酮 as an Impurity". Talanta, 2024, 1703, (5), 5996-6019.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of (1aR,2E,4aR,6S,7S,7aR,8S,9Z,11aS)-4a,7,8-Trihydroxy-9-(hydroxymethyl)-1,1,3,6-tetramethyl-1,1a,4a,5,6,7,7a,8,11,11a-decahydro-4H-cyclopenta[a]cyclopropa[f][11]annulen-4-one Using HRMS and NMR". J. Nat. Prod., 2012, 1070, 6967-6989.

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