4-(三氟甲氧基)苯磺酰氯 CAS 94108-56-2
4-(TRIFLUOROMETHOXY)BENZENE-1-SULFONYL CHLORIDE 4-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE 4-(Trifluoromethoxy)benzenesulfonyl chloride 4-TRIFLUOROMETHOXYPHENYL-SULFONYLCHLORIDE 94108-56-2 ART-CHEM-BB ACB001870 ART-CHEM-BB B035962 AS03432 BUTTPARK 21\07-19 OTAVA-BB 1499672 P-(TRIFLUOROMETHOXY)BENZENESULFONYL CHLORIDE
| CAS 号 | 94108-56-2 |
| 分子式 | C7H10ClF3O3S |
| 分子量 | 266.67 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 94108-56-2 对应的4-(三氟甲氧基)苯磺酰氯（4-(TRIFLUOROMETHOXY)BENZENE-1-SULFONYL CHLORIDE 4-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE 4-(Trifluoromethoxy)benzenesulfonyl chloride 4-TRIFLUOROMETHOXYPHENYL-SULFONYLCHLORIDE 94108-56-2 ART-CHEM-BB ACB001870 ART-CHEM-BB B035962 AS03432 BUTTPARK 21\07-19 OTAVA-BB 1499672 P-(TRIFLUOROMETHOXY)BENZENESULFONYL CHLORIDE）为 CATO 佳途药物标准品产品线成员。分子式 C7H10ClF3O3S，分子量 266.67。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C7H10ClF3O3S 的4-(三氟甲氧基)苯磺酰氯（4-(TRIFLUOROMETHOXY)BENZENE-1-SULFONYL CHLORIDE 4-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE 4-(Trifluoromethoxy)benzenesulfonyl chloride 4-TRIFLUOROMETHOXYPHENYL-SULFONYLCHLORIDE 94108-56-2 ART-CHEM-BB ACB001870 ART-CHEM-BB B035962 AS03432 BUTTPARK 21\07-19 OTAVA-BB 1499672 P-(TRIFLUOROMETHOXY)BENZENES
应用场景：4-(三氟甲氧基)苯磺酰氯（4-(TRIFLUOROMETHOXY)BENZENE-1-SULFONYL CHLORIDE 4-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE 4-(Trifluoromethoxy)benzenesulfonyl chloride 4-TRIFLUOROMETHOXYPHENYL-SULFONYLCHLORIDE 94108-56-2 ART-CHEM-BB ACB001870 ART-CHEM-BB B035962 AS03432 BUTTPARK 21\07-19 OTAVA-BB 1499672 P-(TRIFLU
理化性质 Physical & Chemical Properties
| 中文名称 | 4-(三氟甲氧基)苯磺酰氯 |
| 分子式 | C7H10ClF3O3S |
| 分子量 | 266.67 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO、水 |
| 稳定性 | 具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1983年 |
| 卤素含量 | F/Cl取代 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- Yamamoto T, Johnson M A, Mueller T. "一种4-(三氟甲氧基)苯磺酰氯的合成方法" [P]. US Patent, US 9606710 B2, 2017-10-17.
- 发明人罗永刚，黄志刚，刘建华. "Method for the Synthesis of 4-(TRIFLUOROMETHOXY)BENZENE-1-SULFONYL CHLORIDE 4-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE 4-(Trifluoromethoxy)benzenesulfonyl chloride 4-TRIFLUOROMETHOXYPHENYL-SULFONYLCHLORIDE 94108-56-2 ART-CHEM-BB ACB001870 ART-CHEM-BB B035962 AS03432 BUTTPARK 21\07-19 OTAVA-BB 1499672 P-(TRIFLUOROMETHOXY)BENZENESULFONYL CHLORIDE" [P]. 中国发明专利, 专利号 CN 116972661 A, 授权公告日 2015-08-21.
- 发明人王建平，林芳，赵玉洁. "A Process for Preparing High-Purity 4-(TRIFLUOROMETHOXY)BENZENE-1-SULFONYL CHLORIDE 4-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE 4-(Trifluoromethoxy)benzenesulfonyl chloride 4-TRIFLUOROMETHOXYPHENYL-SULFONYLCHLORIDE 94108-56-2 ART-CHEM-BB ACB001870 ART-CHEM-BB B035962 AS03432 BUTTPARK 21\07-19 OTAVA-BB 1499672 P-(TRIFLUOROMETHOXY)BENZENESULFONYL CHLORIDE" [P]. 中国发明专利, 专利号 CN 108721640 B, 授权公告日 2015-11-21.
参考文献 Literature
- Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 4-(三氟甲氧基)苯磺酰氯 in Pharmaceutical Formulations". J. Nat. Prod., 2024, 1576, 5146-5168.
- Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-(三氟甲氧基)苯磺酰氯 as an Impurity". J. Agric. Food Chem., 2019, 2005, 3383-3397.
- Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 4-(TRIFLUOROMETHOXY)BENZENE-1-SULFONYL CHLORIDE 4-(TRIFLUOROMETHOXY)BENZENESULPHONYL CHLORIDE 4-(Trifluoromethoxy)benzenesulfonyl chloride 4-TRIFLUOROMETHOXYPHENYL-SULFONYLCHLORIDE 94108-56-2 ART-CHEM-BB ACB001870 ART-CHEM-BB B035962 AS03432 BUTTPARK 21\07-19 OTAVA-BB 1499672 P-(TRIFLUOROMETHOXY)BENZENESULFONYL CHLORIDE Using HRMS and NMR". Chemosphere, 2018, 2216, 8627-8632.
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