3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl CAS 951908-88-6

3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl

纯度 97%+现货药物标准品
CAS 号951908-88-6
分子式C14H12N2O2S
分子量272.32 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl 3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl CAS 951908-88-6 结构式 Chemical Structure

产品介绍 Description

3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl（3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl，CAS 号 951908-88-6）是 CATO 佳途自主生产的药物标准品，分子式 C14H12N2O2S，分子量 272.32。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，3-methyl-6-(4-methylphenyl)imidazo2,1-b1,3thiazole-2-carboxylic acid,HCl的分子量为272.32 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 3-methyl-6-(4-methylphenyl)imidazo2,1-b1,3thiazole-2-carboxylic acid,HCl（3-methyl-6-(4-methylphenyl)imidazo2,1-b1,3thiazole-2-carboxylic acid,HCl），CAS注册编号 951908-88-6，化学分子式为 C14H12N2O2S，分子量 272.32 g/mol。 3-methyl-6-(4-methylphenyl)imidazo2,1-b1,3thiazole-2-carboxylic acid,HCl（分子式 C14H12N2O2S）的化学结构中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（log

应用场景：针对化学分析用途，3-methyl-6-(4-methylphenyl)imidazo 2,1-b 1,3 thiazole-2-carboxylic acid,HCl（3-methyl-6-(4-methylphenyl)imidazo 2,1-b 1,3 thiazole-2-carboxylic acid,HCl）是具有明确定量溯源的认证级对照品。 推荐以3-methyl-6-(4-methylphenyl)imidazo 2,1-b 1,3 thiazole-2-carboxylic acid,HCl配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1

理化性质 Physical & Chemical Properties

中文名称3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl
分子式C14H12N2O2S
分子量272.32 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. 发明人杨光，朱建伟，周伟. "一种3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl的合成方法" [P]. 中国发明专利, 专利号 CN 112150855 A, 授权公告日 2018-11-18.
  2. 发明人李文辉，何建平，陈志强. "Method for the Synthesis of 3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl" [P]. 中国发明专利, 专利号 CN 110895364 B, 授权公告日 2017-06-27.
  3. Schröder R, Lefèvre J P, Johansson L. "A Process for Preparing High-Purity 3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl" [P]. European Patent, EP 3115104 A1, 2015-12-18.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl in Pharmaceutical Formulations". Biomed. Chromatogr., 2013, 1402, (5), 9757-9760.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl as an Impurity". Anal. Chim. Acta, 2016, 1526, (5), 5919-5927.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 3-methyl-6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxylic acid,HCl Using HRMS and NMR". J. Nat. Prod., 2019, 1660, (7), 875-895.

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