反式-1,4-二苯基-2-丁烯-1,4-二酮 CAS 959-28-4

(2e)-1,4-diphenyl-2-butene-1,4-dione (E)-1,4-diphenyl-but-2-ene-1,4-dione 1,2-dibenzoylethylene 1,4-diphenyl-2-butene-1,4-dione 2-butene-1,4-dione, 1,4-diphenyl- 2-butene-1,4-dione, 1,4-diphenyl-, (e)- 4-diphenyl-4-dion(e)-2-butene-1 959-28-4 timtec-bb sbb007664 trans - 1,2 - Dibenzoylethylene trans-1,2-dibenzoylethylene trans-1,4-Diphenyl-2-butene-1,4-dione trans-diphenacylidene

纯度 97%+现货药物标准品
CAS 号959-28-4
分子式C16H24O2
分子量248.36 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

反式-1,4-二苯基-2-丁烯-1,4-二酮 (2e)-1,4-diphenyl-2-butene-1,4-dione (E)-1,4-diphenyl-but-2-ene-1,4-dione 1,2-dibenzoylethylene 1,4-diphenyl-2-butene-1,4-dione 2-butene-1,4-dione, 1,4-diphenyl- 2-butene-1,4-dione, 1,4-diphenyl-, (e)- 4-diphenyl-4-dion(e)-2-butene-1 959-28-4 timtec-bb sbb007664 trans - 1,2 - Dibenzoylethylene trans-1,2-dibenzoylethylene trans-1,4-Diphenyl-2-butene-1,4-dione trans-diphenacylidene CAS 959-28-4 结构式 Chemical Structure

产品介绍 Description

反式-1,4-二苯基-2-丁烯-1,4-二酮（(2e)-1,4-diphenyl-2-butene-1,4-dione (E)-1,4-diphenyl-but-2-ene-1,4-dione 1,2-dibenzoylethylene 1,4-diphenyl-2-butene-1,4-dione 2-butene-1,4-dione, 1,4-diphenyl- 2-butene-1,4-dione, 1,4-diphenyl-, (e)- 4-diphenyl-4-dion(e)-2-butene-1 959-28-4 timtec-bb sbb007664 trans - 1,2 - Dibenzoylethylene trans-1,2-dibenzoylethylene trans-1,4-Diphenyl-2-butene-1,4-dione trans-diphenacylidene，CAS 号 959-28-4）是 CATO 佳途自主生产的药物标准品，分子式 C16H24O2，分子量 248.36。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

反式-1,4-二苯基-2-丁烯-1,4-二酮的产生途径与其化学式中羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 959-28-4 对应的化合物反式-1,4-二苯基-2-丁烯-1,4-二酮（英文标识 (2e)-1,4-diphenyl-2-butene-1,4-dione (E)-1,4-diphenyl-but-2-ene-1,4-dione 1,2-dibenzoylethylene 1,4-diphenyl-2-butene-1,4-dione 2-butene-1,4-dione, 1,4-diphenyl- 2-butene-1,4-dione, 1,4-diphenyl-, (e)- 4-diphenyl-4-dion(e)-2-butene-1 959-28-4 timtec-bb sbb007664 trans - 1,2 - Dibenzoylethylene trans-1,2-dibenzoylethylene trans-1,4-Diphenyl-2-butene-1,4-dione trans-dip

应用场景：从实际应用出发，反式-1,4-二苯基-2-丁烯-1,4-二酮（CAS 959-28-4）在化学分析中作为关键的基准对照物质。 推荐以反式-1,4-二苯基-2-丁烯-1,4-二酮配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于室温保存条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称反式-1,4-二苯基-2-丁烯-1,4-二酮
分子式C16H24O2
分子量248.36 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年

相关专利 Related Patents

  1. 发明人沈红梅，马晓峰，王建平. "一种反式-1,4-二苯基-2-丁烯-1,4-二酮的合成方法" [P]. 中国发明专利, 专利号 CN 112340614 A, 授权公告日 2022-05-18.
  2. 发明人罗永刚，陈志强，唐晓军. "Method for the Synthesis of (2e)-1,4-diphenyl-2-butene-1,4-dione (E)-1,4-diphenyl-but-2-ene-1,4-dione 1,2-dibenzoylethylene 1,4-diphenyl-2-butene-1,4-dione 2-butene-1,4-dione, 1,4-diphenyl- 2-butene-1,4-dione, 1,4-diphenyl-, (e)- 4-diphenyl-4-dion(e)-2-butene-1 959-28-4 timtec-bb sbb007664 trans - 1,2 - Dibenzoylethylene trans-1,2-dibenzoylethylene trans-1,4-Diphenyl-2-butene-1,4-dione trans-diphenacylidene" [P]. 中国发明专利, 专利号 CN 109897349 A, 授权公告日 2020-01-15.
  3. Chen K W, Davis P L, Park J H. "A Process for Preparing High-Purity (2e)-1,4-diphenyl-2-butene-1,4-dione (E)-1,4-diphenyl-but-2-ene-1,4-dione 1,2-dibenzoylethylene 1,4-diphenyl-2-butene-1,4-dione 2-butene-1,4-dione, 1,4-diphenyl- 2-butene-1,4-dione, 1,4-diphenyl-, (e)- 4-diphenyl-4-dion(e)-2-butene-1 959-28-4 timtec-bb sbb007664 trans - 1,2 - Dibenzoylethylene trans-1,2-dibenzoylethylene trans-1,4-Diphenyl-2-butene-1,4-dione trans-diphenacylidene" [P]. US Patent, US 10875758 B2, 2015-07-21.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 反式-1,4-二苯基-2-丁烯-1,4-二酮 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2014, 2378, (5), 1368-1380.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 反式-1,4-二苯基-2-丁烯-1,4-二酮 as an Impurity". Anal. Chem., 2022, 1400, (6), 3696-3701.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of (2e)-1,4-diphenyl-2-butene-1,4-dione (E)-1,4-diphenyl-but-2-ene-1,4-dione 1,2-dibenzoylethylene 1,4-diphenyl-2-butene-1,4-dione 2-butene-1,4-dione, 1,4-diphenyl- 2-butene-1,4-dione, 1,4-diphenyl-, (e)- 4-diphenyl-4-dion(e)-2-butene-1 959-28-4 timtec-bb sbb007664 trans - 1,2 - Dibenzoylethylene trans-1,2-dibenzoylethylene trans-1,4-Diphenyl-2-butene-1,4-dione trans-diphenacylidene Using HRMS and NMR". Environ. Sci. Technol., 2017, 2003, (10), 7895-7914.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 反式-1,4-二苯基-2-丁烯-1,4-二酮 Profile in Drug Substances According to ICH Guidelines". Molecules, 2024, 552, 3920-3933.

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