CAS 97772-99-1

7-Hydroxy Aminopterin 97772-99-1 N-[4-[[(2,4-Diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]- L-Glutamic Acid N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid N-[p-[[(2,4-Diamino-7-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid

纯度 97%+现货药物标准品
CAS 号97772-99-1
分子式C19H20N8O6
分子量456.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7-Hydroxy Aminopterin 97772-99-1 N-[4-[[(2,4-Diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]- L-Glutamic Acid N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid N-[p-[[(2,4-Diamino-7-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid CAS 97772-99-1 结构式 Chemical Structure

产品介绍 Description

（7-Hydroxy Aminopterin 97772-99-1 N-[4-[[(2,4-Diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]- L-Glutamic Acid N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid N-[p-[[(2,4-Diamino-7-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid，CAS 号 97772-99-1）是 CATO 佳途自主生产的药物标准品，分子式 C19H20N8O6，分子量 456.41。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，的分子量为456.41 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 97772-99-1 对应的化合物（英文标识 7-Hydroxy Aminopterin 97772-99-1 N-4-(2,4-Diamino-1,7-dihydro-7-oxo-6-pteridinyl)methylaminobenzoyl- L-Glutamic Acid N-4-(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methylaminobenzoyl-L-glutamic Acid N-p-(2,4-Diamino-7-hydroxy-6-pteridinyl)methylaminobenzoyl-L-glutamic Acid），化学式 C19H20N8O6，相对分子质量 456.41。 从化学结构特征来看，的分子骨架中包含黄酮骨架，酰胺类，含羟基，含醚键。该化合物的不饱和度为14.0，表明结构中存在约14个环或双键等价单元。分子量为456.41 g/mol，

应用场景：（7-Hydroxy Aminopterin 97772-99-1 N- 4- (2,4-Diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl amino benzoyl - L-Glutamic Acid N- 4- (2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl amino benzoyl -L-glutamic Acid N- p- (2,4-Diamino-7-hydroxy-6-pteridinyl)methyl amino benzoyl -L-glutamic Acid）作为药物标准

理化性质 Physical & Chemical Properties

中文名称
分子式C19H20N8O6
分子量456.41 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）14.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年
含氮原子数8

相关专利 Related Patents

  1. 发明人高志强，黄志刚，李文辉. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111088502 B, 授权公告日 2021-09-26.
  2. 发明人杨光，沈红梅，何建平. "Method for the Synthesis of 7-Hydroxy Aminopterin 97772-99-1 N-[4-[[(2,4-Diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]- L-Glutamic Acid N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid N-[p-[[(2,4-Diamino-7-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid" [P]. 中国发明专利, 专利号 CN 115502145 B, 授权公告日 2021-03-01.
  3. Nowak P, Nielsen H, Lefèvre J P. "A Process for Preparing High-Purity 7-Hydroxy Aminopterin 97772-99-1 N-[4-[[(2,4-Diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]- L-Glutamic Acid N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid N-[p-[[(2,4-Diamino-7-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid" [P]. European Patent, EP 3616943 A1, 2024-06-04.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chem., 2012, 1558, (12), 6361-6385.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Biomed. Chromatogr., 2013, 324, (1), 9198-9208.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 7-Hydroxy Aminopterin 97772-99-1 N-[4-[[(2,4-Diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]- L-Glutamic Acid N-[4-[[(2,4-Diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid N-[p-[[(2,4-Diamino-7-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid Using HRMS and NMR". Phytochemistry, 2017, 1921, (2), 4942-4958.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2015, 589, (5), 4934-4963.

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