4-碘苯磺酰氯 CAS 98-61-3

98-61-3 MVL274EZOG Pipsyl chloride Pipsyl choride Benzenesulfonyl chloride, p-iodo- (8CI) Benzenesulfonyl chloride, 4-iodo- 4-Iodobenzenesulfonyl chloride p-Iodobenzenesulphonyl chloride EINECS 202-686-9 Iodobenzene-p-sulfonyl chloride 4-Iodobenzenesulphonyl chloride NSC 77079 UNII-MVL274EZOG

纯度 97%+现货药物标准品
CAS 号98-61-3
分子式C6H10ClIO2S
分子量308.56 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-碘苯磺酰氯 98-61-3 MVL274EZOG Pipsyl chloride Pipsyl choride Benzenesulfonyl chloride, p-iodo- (8CI) Benzenesulfonyl chloride, 4-iodo- 4-Iodobenzenesulfonyl chloride p-Iodobenzenesulphonyl chloride EINECS 202-686-9 Iodobenzene-p-sulfonyl chloride 4-Iodobenzenesulphonyl chloride NSC 77079 UNII-MVL274EZOG CAS 98-61-3 结构式 Chemical Structure

产品介绍 Description

CAS 98-61-3 对应的4-碘苯磺酰氯（98-61-3 MVL274EZOG Pipsyl chloride Pipsyl choride Benzenesulfonyl chloride, p-iodo- (8CI) Benzenesulfonyl chloride, 4-iodo- 4-Iodobenzenesulfonyl chloride p-Iodobenzenesulphonyl chloride EINECS 202-686-9 Iodobenzene-p-sulfonyl chloride 4-Iodobenzenesulphonyl chloride NSC 77079 UNII-MVL274EZOG）为 CATO 佳途药物标准品产品线成员。分子式 C6H10ClIO2S，分子量 308.56。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

4-碘苯磺酰氯的产生途径与其化学式中含砜基，羧酸类，含羟基，含醚键，含氯/碘取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C6H10ClIO2S 的4-碘苯磺酰氯（98-61-3 MVL274EZOG Pipsyl chloride Pipsyl choride Benzenesulfonyl chloride, p-iodo- (8CI) Benzenesulfonyl chloride, 4-iodo- 4-Iodobenzenesulfonyl chloride p-Iodobenzenesulphonyl chloride EINECS 202-686-9 Iodobenzene-p-sulfonyl chloride 4-Iodobenzenesulphonyl chloride NSC 77079 UNII-MVL274EZOG），其CAS登记号是 98-61-3，分子量为 308.56 g/mol。 4-碘苯磺酰氯（C6H10ClIO2S）含有含砜基，羧酸类，含羟基，含醚键，含氯/碘取代。卤素取代增加了化合物的密度和沸点，羧基赋

应用场景：4-碘苯磺酰氯（98-61-3 MVL274EZOG Pipsyl chloride Pipsyl choride Benzenesulfonyl chloride, p-iodo- (8CI) Benzenesulfonyl chloride, 4-iodo- 4-Iodobenzenesulfonyl chloride p-Iodobenzenesulphonyl chloride EINECS 202-686-9 Iodobenzene-p-sulfonyl chloride 4-Iodobenzenesulphonyl chloride NSC 77079 UNII-MVL274EZO

理化性质 Physical & Chemical Properties

中文名称4-碘苯磺酰氯
分子式C6H10ClIO2S
分子量308.56 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件室温保存
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
卤素含量Cl/I取代
含硫原子数1

相关专利 Related Patents

  1. Martínez F, Rossi M, Nowak P. "一种4-碘苯磺酰氯的合成方法" [P]. European Patent, EP 3871880 A1, 2020-11-27.
  2. 发明人杨光，赵玉洁，王建平. "Method for the Synthesis of 98-61-3 MVL274EZOG Pipsyl chloride Pipsyl choride Benzenesulfonyl chloride, p-iodo- (8CI) Benzenesulfonyl chloride, 4-iodo- 4-Iodobenzenesulfonyl chloride p-Iodobenzenesulphonyl chloride EINECS 202-686-9 Iodobenzene-p-sulfonyl chloride 4-Iodobenzenesulphonyl chloride NSC 77079 UNII-MVL274EZOG" [P]. 中国发明专利, 专利号 CN 116159494 A, 授权公告日 2025-10-13.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 4-碘苯磺酰氯 in Pharmaceutical Formulations". Talanta, 2020, 1116, 8367-8392.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-碘苯磺酰氯 as an Impurity". Anal. Chem., 2017, 1779, 4306-4328.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 98-61-3 MVL274EZOG Pipsyl chloride Pipsyl choride Benzenesulfonyl chloride, p-iodo- (8CI) Benzenesulfonyl chloride, 4-iodo- 4-Iodobenzenesulfonyl chloride p-Iodobenzenesulphonyl chloride EINECS 202-686-9 Iodobenzene-p-sulfonyl chloride 4-Iodobenzenesulphonyl chloride NSC 77079 UNII-MVL274EZOG Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2024, 828, (2), 5900-5928.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 4-碘苯磺酰氯 Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2016, 1029, (3), 7652-7667.

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