发明人高志强,沈红梅,朱建伟. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 117522163 A, 授权公告日 2019-08-12.
Thompson G K, Fischer A B, O'Brien P Q. "Method for the Synthesis of 98185-20-7
EXZ5FGZ55J
Raclopride tartrate
Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-hydroxy-6-methoxy-, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)
(S)-(-)-3,5-Dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-methoxysalicylamide L-(+)-tartrate
UNII-EXZ5FGZ55J" [P]. US Patent, US 11445534 B2, 2020-04-08.
发明人徐明华,马晓峰,何建平. "A Process for Preparing High-Purity 98185-20-7
EXZ5FGZ55J
Raclopride tartrate
Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-hydroxy-6-methoxy-, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)
(S)-(-)-3,5-Dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-methoxysalicylamide L-(+)-tartrate
UNII-EXZ5FGZ55J" [P]. 中国发明专利, 专利号 CN 110977123 B, 授权公告日 2018-04-03.
参考文献 Literature
Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Sep. Sci., 2024, 518, (10), 3677-3696.
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Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 98185-20-7
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Raclopride tartrate
Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-hydroxy-6-methoxy-, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) (salt)
(S)-(-)-3,5-Dichloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-methoxysalicylamide L-(+)-tartrate
UNII-EXZ5FGZ55J Using HRMS and NMR". Chemosphere, 2021, 597, (5), 5464-5474.