(<I> R </I>)-Tol-BINAP CAS 99646-28-3

(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl 99646-28-3 (+/-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-TOL-BINAP;(R)-P-TOL-BINAP;(R)-T-BINAP;(R)-TOL-BINAP;(S)-(-)-(2,2'-P-TOLYL-PHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2-BIS(DI-P-TOLYLPHOSPHINO)-1,1-BINAPHTHYL;(S)-(-)-TOL-BINAP;(S)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-P-TOL-BINAP;(S)-T-BINAP;(S)-TOL-BINAP;1,1'-(1R)-[1,1'-BINAPHTHALENE]-2,2'-DIYLBIS[BIS(4-METHYLPHENYL)]-PHOSPHINE;1,1'-(1S)-[1,1'-BINAPHTHALENE]-2,2'-DIYLBIS[1,1-BIS(4-METHYLPHENYL)]-PHOSPHINE;1,1'-[[1,1'-BINAPHTHALENE]-2,2'-DIYL]BIS[1,1-BIS(4-METHYLPHENYL)]-PHOSPHINE;2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;RAC-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;RAC-P-TOL-BINAP;RAC-P-TOLYL-BINAP;RAC-TOL-BINAP;TOL-BINAP SC11254

纯度 97%+现货药物标准品
CAS 号99646-28-3
分子式C48H84P2
分子量723.13 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I> R </I>)-Tol-BINAP (R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl 99646-28-3 (+/-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-TOL-BINAP;(R)-P-TOL-BINAP;(R)-T-BINAP;(R)-TOL-BINAP;(S)-(-)-(2,2'-P-TOLYL-PHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2-BIS(DI-P-TOLYLPHOSPHINO)-1,1-BINAPHTHYL;(S)-(-)-TOL-BINAP;(S)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-P-TOL-BINAP;(S)-T-BINAP;(S)-TOL-BINAP;1,1'-(1R)-[1,1'-BINAPHTHALENE]-2,2'-DIYLBIS[BIS(4-METHYLPHENYL)]-PHOSPHINE;1,1'-(1S)-[1,1'-BINAPHTHALENE]-2,2'-DIYLBIS[1,1-BIS(4-METHYLPHENYL)]-PHOSPHINE;1,1'-[[1,1'-BINAPHTHALENE]-2,2'-DIYL]BIS[1,1-BIS(4-METHYLPHENYL)]-PHOSPHINE;2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;RAC-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;RAC-P-TOL-BINAP;RAC-P-TOLYL-BINAP;RAC-TOL-BINAP;TOL-BINAP SC11254 CAS 99646-28-3 结构式 Chemical Structure

产品介绍 Description

(<I> R </I>)-Tol-BINAP（(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl 99646-28-3 (+/-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-TOL-BINAP;(R)-P-TOL-BINAP;(R)-T-BINAP;(R)-TOL-BINAP;(S)-(-)-(2,2'-P-TOLYL-PHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2-BIS(DI-P-TOLYLPHOSPHINO)-1,1-BINAPHTHYL;(S)-(-)-TOL-BINAP;(S)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-P-TOL-BINAP;(S)-T-BINAP;(S)-TOL-BINAP;1,1'-(1R)-[1,1'-BINAPHTHALENE]-2,2'-DIYLBIS[BIS(4-METHYLPHENYL)]-PHOSPHINE;1,1'-(1S)-[1,1'-BINAPHTHALENE]-2,2'-DIYLBIS[1,1-BIS(4-METHYLPHENYL)]-PHOSPHINE;1,1'-[[1,1'-BINAPHTHALENE]-2,2'-DIYL]BIS[1,1-BIS(4-METHYLPHENYL)]-PHOSPHINE;2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;RAC-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;RAC-P-TOL-BINAP;RAC-P-TOLYL-BINAP;RAC-TOL-BINAP;TOL-BINAP SC11254，CAS 号 99646-28-3）是 CATO 佳途自主生产的药物标准品，分子式 C48H84P2，分子量 723.13。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

(<I> R </I>)-Tol-BINAP的产生途径与其化学式中有机磷，多环芳烃密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 99646-28-3 对应的化合物(<I> R </I>)-Tol-BINAP（英文标识 (R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl 99646-28-3 (+/-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-TOL-BINAP;(R)-P-TOL-BINAP;(R)-T-BINAP;(R)-TOL-BINAP;(S)-(-)-(2,2'-P-TOLYL-PHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2-BIS(DI-P-TOLYLPHOSPHINO)-

应用场景：(<I> R </I>)-Tol-BINAP（(R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl 99646-28-3 (+/-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-TOL-BINAP;(R)-P-TOL-BINAP;(R)-T-BINAP;(R)-TOL-BINAP;(S)-(-)-(2,2'-P-TOLYL-PHOSPHINO)-1,1'-BINAPHTH

理化性质 Physical & Chemical Properties

中文名称(<I> R </I>)-Tol-BINAP
分子式C48H84P2
分子量723.13 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1985年

相关专利 Related Patents

  1. Johnson M A, Yamamoto T, Fischer A B. "一种(<I> R </I>)-Tol-BINAP的合成方法" [P]. US Patent, US 11225529 B2, 2024-01-20.
  2. Brown S R, O'Brien P Q, Schröder R. "Method for the Synthesis of (R)-(+)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl 99646-28-3 (+/-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(R)-(+)-TOL-BINAP;(R)-P-TOL-BINAP;(R)-T-BINAP;(R)-TOL-BINAP;(S)-(-)-(2,2'-P-TOLYL-PHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-(-)-2,2-BIS(DI-P-TOLYLPHOSPHINO)-1,1-BINAPHTHYL;(S)-(-)-TOL-BINAP;(S)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;(S)-P-TOL-BINAP;(S)-T-BINAP;(S)-TOL-BINAP;1,1'-(1R)-[1,1'-BINAPHTHALENE]-2,2'-DIYLBIS[BIS(4-METHYLPHENYL)]-PHOSPHINE;1,1'-(1S)-[1,1'-BINAPHTHALENE]-2,2'-DIYLBIS[1,1-BIS(4-METHYLPHENYL)]-PHOSPHINE;1,1'-[[1,1'-BINAPHTHALENE]-2,2'-DIYL]BIS[1,1-BIS(4-METHYLPHENYL)]-PHOSPHINE;2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;RAC-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL;RAC-P-TOL-BINAP;RAC-P-TOLYL-BINAP;RAC-TOL-BINAP;TOL-BINAP SC11254" [P]. US Patent, US 11983948 B2, 2018-02-09.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of (<I> R </I>)-Tol-BINAP in Pharmaceutical Formulations". J. Agric. Food Chem., 2017, 1229, (10), 4769-4797.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I> R </I>)-Tol-BINAP as an Impurity". Anal. Chim. Acta, 2022, 2281, 6240-6262.

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