4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide CAS CATO-CCPD103645

4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide

纯度 97%+现货药物标准品
CAS 号CATO-CCPD103645
分子式C18H12Cl2F4N2O3
分子量451.20 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide 4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide CAS CATO-CCPD103645 结构式 Chemical Structure

产品介绍 Description

4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide（4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide）是药物分析与质量控制领域常用的药物标准品，CAS 号 CATO-CCPD103645。分子式 C18H12Cl2F4N2O3，分子量 451.20。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，4-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl-N-hydroxy-2-methylbenzamide的分子量为451.20 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 4-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl-N-hydroxy-2-methylbenzamide（4-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl-N-hydroxy-2-methylbenzamide），CAS注册编号 CATO-CCPD103645，化学分子式为 C18H12Cl2F4N2O3，分子量 451.20 g/mol。 4-5-(3,5-Dichloro-4-fluorophenyl)-5-(t

应用场景：4- 5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl -N-hydroxy-2-methylbenzamide（4- 5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl -N-hydroxy-2-methylbenzamide，CAS CATO-CCPD103645）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以4- 5-(3,5-Dichloro-4-fluoro

理化性质 Physical & Chemical Properties

中文名称4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide
分子式C18H12Cl2F4N2O3
分子量451.20 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
卤素含量F/Cl取代
含氮原子数2

相关专利 Related Patents

  1. O'Brien P Q, Hughes D C, Lee S K. "一种4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide的合成方法" [P]. US Patent, US 10942303 B2, 2024-12-01.
  2. 发明人陈志强，郭海燕，朱建伟. "Method for the Synthesis of 4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide" [P]. 中国发明专利, 专利号 CN 116096776 A, 授权公告日 2020-02-12.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide in Pharmaceutical Formulations". Anal. Chem., 2011, 2190, (4), 2752-2760.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide as an Impurity". Anal. Chim. Acta, 2018, 1554, (9), 9822-9850.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of 4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide Using HRMS and NMR". Molecules, 2018, 1071, (4), 7308-7325.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate 4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2016, 115, (8), 4859-4882.

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