5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid CAS 1011397-37-7

5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1011397-37-7
分子式C19H18ClN3O2
分子量355.82 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid CAS 1011397-37-7 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid（5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid）为药物标准品，CAS 登记号 1011397-37-7，分子式 C19H18ClN3O2，分子量 355.82。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 1011397-37-7 对应的化合物5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo3,4-bpyridine-4-carboxylic acid（英文标识 5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo3,4-bpyridine-4-carboxylic acid），化学式 C19H18ClN3O2，相对分子质量 355.82。 5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo3,4-bpyridine-4-carboxylic acid（C19H18ClN3O2）含有甾体骨架，酰胺类，含羟基，含醚键，含氯取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，

应用场景：从实际应用出发，5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid（CAS 1011397-37-7）在化学分析中作为关键的基准对照物质。 推荐以5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求

理化性质 Physical & Chemical Properties

中文名称5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
分子式C19H18ClN3O2
分子量355.82 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）12.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. Lefèvre J P, Björnsson E, Nowak P. "一种5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid的合成方法" [P]. European Patent, EP 3905586 A1, 2025-06-22.
  2. 发明人王建平，韩伟，林芳. "Method for the Synthesis of 5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid" [P]. 中国发明专利, 专利号 CN 108220898 B, 授权公告日 2016-12-14.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid in Pharmaceutical Formulations". Molecules, 2012, 2078, (1), 9265-9276.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid as an Impurity". Rapid Commun. Mass Spectrom., 2015, 909, (4), 4145-4169.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid Using HRMS and NMR". J. Agric. Food Chem., 2015, 934, (12), 1470-1484.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 5-chloro-6-cyclopropyl-3-methyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2011, 403, (1), 78-81.

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