1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid CAS 1018142-06-7

1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1018142-06-7
分子式C18H22N4O3
分子量342.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid CAS 1018142-06-7 结构式 Chemical Structure

产品介绍 Description

CAS 1018142-06-7 对应的1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid（1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C18H22N4O3，分子量 342.39。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在质量保证方面，1-2-(cyclopentylamino)-2-oxoethyl-6-cyclopropyl-3-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 1018142-06-7 对应的化合物1-2-(cyclopentylamino)-2-oxoethyl-6-cyclopropyl-3-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid（英文标识 1-2-(cyclopentylamino)-2-oxoethyl-6-cyclopropyl-3-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid），化学式 C18H22N4O3

应用场景：针对化学分析用途，1- 2-(cyclopentylamino)-2-oxoethyl -6-cyclopropyl-3-methyl-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid（1- 2-(cyclopentylamino)-2-oxoethyl -6-cyclopropyl-3-methyl-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以1- 2-(cyclopentylamino)-2-oxoethyl -6-cyclopropyl-3-methyl-1H

理化性质 Physical & Chemical Properties

中文名称1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
分子式C18H22N4O3
分子量342.39 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数4

相关专利 Related Patents

  1. 发明人陈志强，林芳，钱学锋. "一种1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 108175510 A, 授权公告日 2023-02-10.
  2. Chen K W, O'Brien P Q, Davis P L. "Method for the Synthesis of 1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid" [P]. US Patent, US 9349174 B2, 2024-06-08.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid in Pharmaceutical Formulations". J. Nat. Prod., 2015, 1325, 4668-4695.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid as an Impurity". Phytochemistry, 2017, 2426, (7), 4137-4154.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 1-[2-(cyclopentylamino)-2-oxoethyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid Using HRMS and NMR". Environ. Sci. Technol., 2025, 997, (1), 8860-8875.

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