CAS 131740-09-5

131740-09-5 D48MS3A6N9 Alvocidib [USAN:INN:BAN] Alvocidib hydrochloride [USAN] 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)- Alvocidib hydrochloride HMR 1275 MDL 107826A Flavopiridol NSC 649890 UNII-D48MS3A6N9 Alvocidib HL 275 L 86 8275 MDL 107,826A HL-275 HMR-1275 L86-8275 MDL-107826A

纯度 97%+现货药物标准品
CAS 号131740-09-5
分子式C21H20ClNO5 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

131740-09-5 D48MS3A6N9 Alvocidib [USAN:INN:BAN] Alvocidib hydrochloride [USAN] 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)- Alvocidib hydrochloride HMR 1275 MDL 107826A Flavopiridol NSC 649890 UNII-D48MS3A6N9 Alvocidib HL 275 L 86 8275 MDL 107,826A HL-275 HMR-1275 L86-8275 MDL-107826A CAS 131740-09-5 结构式 Chemical Structure

产品介绍 Description

（131740-09-5 D48MS3A6N9 Alvocidib [USAN:INN:BAN] Alvocidib hydrochloride [USAN] 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)- Alvocidib hydrochloride HMR 1275 MDL 107826A Flavopiridol NSC 649890 UNII-D48MS3A6N9 Alvocidib HL 275 L 86 8275 MDL 107,826A HL-275 HMR-1275 L86-8275 MDL-107826A）是药物分析与质量控制领域常用的药物标准品，CAS 号 131740-09-5。分子式 C21H20ClNO5 HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

的产生途径与其化学式中黄酮骨架，酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C21H20ClNO5 HCl 的（131740-09-5 D48MS3A6N9 Alvocidib USAN:INN:BAN Alvocidib hydrochloride USAN 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)- Alvocidib hydrochloride HMR 1275 MDL 107826A Flavopiridol NSC 649890 UNII-D48MS3A6N9 Alvocidi

应用场景：（131740-09-5 D48MS3A6N9 Alvocidib USAN:INN:BAN Alvocidib hydrochloride USAN 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochl

理化性质 Physical & Chemical Properties

中文名称
分子式C21H20ClNO5 HCl
分子量438.30 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Rossi M, Mueller T C, Johansson L. "一种的合成方法" [P]. European Patent, EP 3944658 A1, 2024-11-26.
  2. Anderson J P, Davis P L, Park J H. "Method for the Synthesis of 131740-09-5 D48MS3A6N9 Alvocidib [USAN:INN:BAN] Alvocidib hydrochloride [USAN] 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)- Alvocidib hydrochloride HMR 1275 MDL 107826A Flavopiridol NSC 649890 UNII-D48MS3A6N9 Alvocidib HL 275 L 86 8275 MDL 107,826A HL-275 HMR-1275 L86-8275 MDL-107826A" [P]. US Patent, US 10543833 B2, 2016-11-08.
  3. 发明人李文辉，刘建华，胡光. "A Process for Preparing High-Purity 131740-09-5 D48MS3A6N9 Alvocidib [USAN:INN:BAN] Alvocidib hydrochloride [USAN] 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)- Alvocidib hydrochloride HMR 1275 MDL 107826A Flavopiridol NSC 649890 UNII-D48MS3A6N9 Alvocidib HL 275 L 86 8275 MDL 107,826A HL-275 HMR-1275 L86-8275 MDL-107826A" [P]. 中国发明专利, 专利号 CN 115388425 A, 授权公告日 2019-04-04.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Chemosphere, 2013, 380, 5235-5263.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Rapid Commun. Mass Spectrom., 2011, 98, (4), 5221-5248.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 131740-09-5 D48MS3A6N9 Alvocidib [USAN:INN:BAN] Alvocidib hydrochloride [USAN] 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, cis-(-)- Alvocidib hydrochloride HMR 1275 MDL 107826A Flavopiridol NSC 649890 UNII-D48MS3A6N9 Alvocidib HL 275 L 86 8275 MDL 107,826A HL-275 HMR-1275 L86-8275 MDL-107826A Using HRMS and NMR". J. Sep. Sci., 2011, 641, 4858-4869.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Molecules, 2023, 2455, (4), 1809-1815.

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