(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine CAS 1365531-99-2

(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>- butyl-4-methoxyphenyl)phosphine

纯度 97%+现货药物标准品
CAS 号1365531-99-2
分子式C76H144O8P2
分子量1247.90 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine (<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>- butyl-4-methoxyphenyl)phosphine CAS 1365531-99-2 结构式 Chemical Structure

产品介绍 Description

(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine（英文名 (<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>- butyl-4-methoxyphenyl)phosphine，CAS 1365531-99-2）属于药物标准品。分子式 C76H144O8P2，分子量 1247.90。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 化学式为 C76H144O8P2 的(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine（(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>- butyl-4-methoxyphenyl)phosphine），其CAS登记号是 1365531-99-2，分子量为 1247.90 g/mol。 受分子结构中含磷酸酯基，羧酸类，含羟基，含醚键的影响，(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine表现为

应用场景：在化学分析实验室中，(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine（CAS 1365531-99-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine配制标准系列工作溶液，用于建立标

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine
分子式C76H144O8P2
分子量1247.90 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年

相关专利 Related Patents

  1. 发明人朱建伟，王建平，孙丽萍. "一种(<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine的合成方法" [P]. 中国发明专利, 专利号 CN 109323974 A, 授权公告日 2016-02-22.
  2. 发明人徐明华，张德明，郑宇鹏. "Method for the Synthesis of (<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>- butyl-4-methoxyphenyl)phosphine" [P]. 中国发明专利, 专利号 CN 115423905 A, 授权公告日 2023-01-26.
  3. 发明人孙丽萍，罗永刚，马晓峰. "A Process for Preparing High-Purity (<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>- butyl-4-methoxyphenyl)phosphine" [P]. 中国发明专利, 专利号 CN 114030107 A, 授权公告日 2025-02-17.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine in Pharmaceutical Formulations". Phytochemistry, 2015, 2007, 7974-7990.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine as an Impurity". J. Agric. Food Chem., 2019, 1090, (4), 1673-1703.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of (<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>- butyl-4-methoxyphenyl)phosphine Using HRMS and NMR". Anal. Methods, 2012, 372, (11), 2523-2548.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate (<I>S</I>)-(4,4′,6,6′-Tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-di-<I>tert</I>-butyl-4-methoxyphenyl)phosphine Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2015, 626, (9), 9111-9131.

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