CAS 16891-85-3

(1'R,2S,4'E,6'E,8'R,12'Z,16A'R,20a'R,22'R,23a'S)-8'-((R)-1-hydroxyethyl)-12',19',23a'-trimethyl-1',10',11',18',20a',23a'-hexahydro-14'H,16'H,17'H,22'H-spiro[oxirane-2,23'-[1,22]methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene]-3',14'(8'H)-dione

纯度 97%+现货药物标准品
CAS 号16891-85-3
分子式C29H38O8
分子量514.61 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1'R,2S,4'E,6'E,8'R,12'Z,16A'R,20a'R,22'R,23a'S)-8'-((R)-1-hydroxyethyl)-12',19',23a'-trimethyl-1',10',11',18',20a',23a'-hexahydro-14'H,16'H,17'H,22'H-spiro[oxirane-2,23'-[1,22]methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene]-3',14'(8'H)-dione CAS 16891-85-3 结构式 Chemical Structure

产品介绍 Description

CAS 16891-85-3 对应的（(1'R,2S,4'E,6'E,8'R,12'Z,16A'R,20a'R,22'R,23a'S)-8'-((R)-1-hydroxyethyl)-12',19',23a'-trimethyl-1',10',11',18',20a',23a'-hexahydro-14'H,16'H,17'H,22'H-spiro[oxirane-2,23'-[1,22]methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene]-3',14'(8'H)-dione）为 CATO 佳途药物标准品产品线成员。分子式 C29H38O8，分子量 514.61。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，的分子量为514.61 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 16891-85-3 对应的化合物（英文标识 (1'R,2S,4'E,6'E,8'R,12'Z,16A'R,20a'R,22'R,23a'S)-8'-((R)-1-hydroxyethyl)-12',19',23a'-trimethyl-1',10',11',18',20a',23a'-hexahydro-14'H,16'H,17'H,22'H-spirooxirane-2,23'-1,22methano1,6,12trioxacyclooctadecino3,4-dchromene-3',14'(8'H)-dione），化学式 C29H38O8，相对分子质量 514.61。 依据分子式为 C29H38O8 的结构特征，其分子内含羧酸类，含羟基，含醚键，多环芳烃，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 514.61 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。由于结构中存在共轭发色团，该化合物在200

应用场景：针对化学分析用途，（(1'R,2S,4'E,6'E,8'R,12'Z,16A'R,20a'R,22'R,23a'S)-8'-((R)-1-hydroxyethyl)-12',19',23a'-trimethyl-1',10',11',18',20a',23a'-hexahydro-14'H,16'H,17'H,22'H-spiro oxirane-2,23'- 1,22 methano 1,6,12 trioxacyclooctadecino 3,4-d chromene -3',14'(8'H)-dione）是具有明确定量溯源的认证级对照品。 推荐以配制标准系列工作溶液，用于建立标准曲线实

理化性质 Physical & Chemical Properties

中文名称
分子式C29H38O8
分子量514.61 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1961年

相关专利 Related Patents

  1. Brown S R, O'Brien P Q, Schröder R. "一种的合成方法" [P]. US Patent, US 9275448 B2, 2023-10-04.
  2. Yamamoto T, O'Brien P Q, Brown S R. "Method for the Synthesis of (1'R,2S,4'E,6'E,8'R,12'Z,16A'R,20a'R,22'R,23a'S)-8'-((R)-1-hydroxyethyl)-12',19',23a'-trimethyl-1',10',11',18',20a',23a'-hexahydro-14'H,16'H,17'H,22'H-spiro[oxirane-2,23'-[1,22]methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene]-3',14'(8'H)-dione" [P]. US Patent, US 10474360 B2, 2024-11-27.
  3. Schröder R, Brown S R, Fischer A B. "A Process for Preparing High-Purity (1'R,2S,4'E,6'E,8'R,12'Z,16A'R,20a'R,22'R,23a'S)-8'-((R)-1-hydroxyethyl)-12',19',23a'-trimethyl-1',10',11',18',20a',23a'-hexahydro-14'H,16'H,17'H,22'H-spiro[oxirane-2,23'-[1,22]methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene]-3',14'(8'H)-dione" [P]. US Patent, US 11531154 B2, 2016-03-22.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Chemosphere, 2018, 1204, (12), 9531-9560.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chim. Acta, 2018, 1708, (4), 9284-9293.

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