6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile CAS 1909348-67-9

6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

纯度 97%+现货药物标准品
CAS 号1909348-67-9
分子式C9H12N4O2
分子量208.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile CAS 1909348-67-9 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile（6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile，CAS 1909348-67-9），分子式 C9H12N4O2，分子量 208.22。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在质量保证方面，6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 1909348-67-9 对应的化合物6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile（英文标识 6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile），化学式 C9H12N4O2，相对分子质量 208.22。 6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-

应用场景：6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile（6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
分子式C9H12N4O2
分子量208.22 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
含氮原子数4

相关专利 Related Patents

  1. 发明人孙丽萍，钱学锋，马晓峰. "一种6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile的合成方法" [P]. 中国发明专利, 专利号 CN 117068334 B, 授权公告日 2015-12-06.
  2. Patel M V, Yamamoto T, Roberts E F. "Method for the Synthesis of 6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile" [P]. US Patent, US 11575882 B2, 2024-08-20.
  3. 发明人胡光，李文辉，郑宇鹏. "A Process for Preparing High-Purity 6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile" [P]. 中国发明专利, 专利号 CN 113625564 A, 授权公告日 2021-02-13.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile in Pharmaceutical Formulations". Chromatographia, 2023, 423, 5286-5316.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile as an Impurity". Anal. Chim. Acta, 2016, 1102, (2), 4304-4308.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 6-(dimethylamino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile Using HRMS and NMR". J. Sep. Sci., 2010, 357, (1), 9937-9954.

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