rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate CAS 2059908-74-4

rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate

纯度 97%+现货药物标准品
CAS 号2059908-74-4
分子式C12H14N2O3
分子量234.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate CAS 2059908-74-4 结构式 Chemical Structure

产品介绍 Description

rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate（rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 2059908-74-4。分子式 C12H14N2O3，分子量 234.25。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate的产生途径与其化学式中氨基酸衍生物，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate（rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate），CAS注册编号 2059908-74-4，化学分子式为 C12H14N2O3，分子量 234.25 g/mol。 rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate（分子式 C12H14N2O3）的化学结构中包含氨基酸衍生物，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响

应用场景：从实际应用出发，rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate（CAS 2059908-74-4）在化学分析中作为关键的基准对照物质。 推荐以rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分

理化性质 Physical & Chemical Properties

中文名称rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate
分子式C12H14N2O3
分子量234.25 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
含氮原子数2

相关专利 Related Patents

  1. 发明人黄志刚，刘建华，胡光. "一种rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 115203328 B, 授权公告日 2019-08-01.
  2. 发明人韩伟，胡光，周伟. "Method for the Synthesis of rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate" [P]. 中国发明专利, 专利号 CN 108434242 A, 授权公告日 2025-05-08.
  3. 发明人郭海燕，高志强，陈志强. "A Process for Preparing High-Purity rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate" [P]. 中国发明专利, 专利号 CN 111266835 A, 授权公告日 2021-10-08.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate in Pharmaceutical Formulations". Environ. Sci. Technol., 2020, 986, (2), 9185-9206.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate as an Impurity". J. Agric. Food Chem., 2017, 1852, 8126-8132.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of rac-methyl (2R,3R)-1-methyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate Using HRMS and NMR". J. Chromatogr. A, 2013, 2325, (6), 3838-3853.

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