3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride CAS 2060041-37-2

3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride

纯度 97%+现货药物标准品
CAS 号2060041-37-2
分子式C13H11F4N3O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride 3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride CAS 2060041-37-2 结构式 Chemical Structure

产品介绍 Description

3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride（3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 2060041-37-2。分子式 C13H11F4N3O HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括3-(3-fluorophenyl)-5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazole hydrochloride在内的目标物的控制。 3-(3-fluorophenyl)-5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazole hydrochloride（3-(3-fluorophenyl)-5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazole hydrochloride），CAS注册编号 2060041-37-2，化学分子式为 C13H11F4N3O HCl，分子量 337.70 g/mol。 依据分子式为 C13H11F4N3O HCl 的3-(3-fluorophenyl)-5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazole hydrochloride结构特征，其分子内含含氮杂环结构

应用场景：针对化学分析用途，3-(3-fluorophenyl)-5- 3-(trifluoromethyl)pyrrolidin-3-yl -1,2,4-oxadiazole hydrochloride（3-(3-fluorophenyl)-5- 3-(trifluoromethyl)pyrrolidin-3-yl -1,2,4-oxadiazole hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以3-(3-fluorophenyl)-5- 3-(trifluoromethyl)pyrrolidin-3-yl -1,2,4-oxadiazole hydrochloride配制标

理化性质 Physical & Chemical Properties

中文名称3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride
分子式C13H11F4N3O HCl
分子量337.70 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量F/Cl取代
含氮原子数3

相关专利 Related Patents

  1. Hughes D C, Brown S R, Yamamoto T. "一种3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride的合成方法" [P]. US Patent, US 10060694 B2, 2020-05-08.
  2. Park J H, Anderson J P, Yamamoto T. "Method for the Synthesis of 3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride" [P]. US Patent, US 10321377 B2, 2024-04-11.
  3. 发明人刘建华，马晓峰，唐晓军. "A Process for Preparing High-Purity 3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride" [P]. 中国发明专利, 专利号 CN 110121060 A, 授权公告日 2023-01-13.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride in Pharmaceutical Formulations". Talanta, 2014, 2187, 3157-3173.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(3-fluorophenyl)-5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazole hydrochloride as an Impurity". Environ. Sci. Technol., 2018, 1079, (2), 4516-4525.

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