CAS 207981-46-2
2-Fluoro-5-(trifluoromethyl)benzoyl chloride 2-fluoro-5-trifluoromethylbenzoyl chloride 2-fluoro-5-trifluoromethylbenzoylchloride 2-fluoro-5-(trifluoromethyl)benzoylchloride 207981-46-2
| CAS 号 | 207981-46-2 |
| 分子式 | C8H3ClF4O |
| 分子量 | 226.56 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 207981-46-2 对应的（2-Fluoro-5-(trifluoromethyl)benzoyl chloride 2-fluoro-5-trifluoromethylbenzoyl chloride 2-fluoro-5-trifluoromethylbenzoylchloride 2-fluoro-5-(trifluoromethyl)benzoylchloride 207981-46-2）为 CATO 佳途药物标准品产品线成员。分子式 C8H3ClF4O，分子量 226.56。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C8H3ClF4O 的（2-Fluoro-5-(trifluoromethyl)benzoyl chloride 2-fluoro-5-trifluoromethylbenzoyl chloride 2-fluoro-5-trifluoromethylbenzoylchloride 2-fluoro-5-(trifluoromethyl)benzoylchloride 207981-46-2），其CAS登记号是 207981-46-2，分子量为 226.56 g/mol。 依据分子式为 C8H3ClF4O 的结构特征，其分子内含含羟基，含醚键，含氟/氯取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 226.56 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 本品定值
应用场景：（2-Fluoro-5-(trifluoromethyl)benzoyl chloride 2-fluoro-5-trifluoromethylbenzoyl chloride 2-fluoro-5-trifluoromethylbenzoylchloride 2-fluoro-5-(trifluoromethyl)benzoylchloride 207981-46-2）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器
理化性质 Physical & Chemical Properties
| 中文名称 | |
| 分子式 | C8H3ClF4O |
| 分子量 | 226.56 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 5.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 2016年 |
| 卤素含量 | F/Cl取代 |
相关专利 Related Patents
- 发明人陈志强，韩伟，刘建华. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 110942866 A, 授权公告日 2015-12-27.
- 发明人郑宇鹏，张德明，马晓峰. "Method for the Synthesis of 2-Fluoro-5-(trifluoromethyl)benzoyl chloride 2-fluoro-5-trifluoromethylbenzoyl chloride 2-fluoro-5-trifluoromethylbenzoylchloride 2-fluoro-5-(trifluoromethyl)benzoylchloride 207981-46-2" [P]. 中国发明专利, 专利号 CN 115291391 A, 授权公告日 2023-07-27.
参考文献 Literature
- Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Environ. Sci. Technol., 2022, 2220, 3373-3399.
- Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Sep. Sci., 2014, 720, (4), 5682-5686.
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