CAS 2199491-27-3

[(2R,3R,4R,5R,6R)-5-acetamido-6-[2-[2-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxycyclohexanecarbonyl]amino]-5-oxo-pentanoyl]amino]-5-oxo-pentanoyl]amino]ethoxy]ethoxy]-3,4-diacetoxy-tetrahydropyran-2-yl]methyl acetate

纯度 97%+现货药物标准品
CAS 号2199491-27-3
分子式C80H127N10O37P
分子量1851.88 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[(2R,3R,4R,5R,6R)-5-acetamido-6-[2-[2-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxycyclohexanecarbonyl]amino]-5-oxo-pentanoyl]amino]-5-oxo-pentanoyl]amino]ethoxy]ethoxy]-3,4-diacetoxy-tetrahydropyran-2-yl]methyl acetate CAS 2199491-27-3 结构式 Chemical Structure

产品介绍 Description

（[(2R,3R,4R,5R,6R)-5-acetamido-6-[2-[2-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxycyclohexanecarbonyl]amino]-5-oxo-pentanoyl]amino]-5-oxo-pentanoyl]amino]ethoxy]ethoxy]-3,4-diacetoxy-tetrahydropyran-2-yl]methyl acetate，CAS 号 2199491-27-3）是 CATO 佳途自主生产的药物标准品，分子式 C80H127N10O37P，分子量 1851.88。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括在内的目标物的控制。 化学式为 C80H127N10O37P 的（(2R,3R,4R,5R,6R)-5-acetamido-6-2-2-(4S)-5-2-2-(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yloxyethoxyethylamino-4-(4S)-5-2-2-(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yloxyethoxyethylamino-4-4-2-cyanoethoxy-(diisopropylamino)phosphanyloxycyclohexanecarbonylamino-5-oxo-pentanoylamino-5-oxo-pentanoylaminoethoxyethoxy-3,4-diacetoxy-tetr

应用场景：（ (2R,3R,4R,5R,6R)-5-acetamido-6- 2- 2- (4S)-5- 2- 2- (2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl oxyethoxy ethylamino -4- (4S)-5- 2- 2- (2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl oxyethoxy ethylamino -4- 4- 2-cyanoethoxy-

理化性质 Physical & Chemical Properties

中文名称
分子式C80H127N10O37P
分子量1851.88 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）22.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1998年
含氮原子数10

相关专利 Related Patents

  1. 发明人赵玉洁，王建平，刘建华. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111977953 A, 授权公告日 2020-02-24.
  2. Kumar R, Fischer A B, Mueller T. "Method for the Synthesis of [(2R,3R,4R,5R,6R)-5-acetamido-6-[2-[2-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxycyclohexanecarbonyl]amino]-5-oxo-pentanoyl]amino]-5-oxo-pentanoyl]amino]ethoxy]ethoxy]-3,4-diacetoxy-tetrahydropyran-2-yl]methyl acetate" [P]. US Patent, US 10332085 B2, 2018-09-26.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Environ. Sci. Technol., 2011, 1083, (6), 6075-6079.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Agric. Food Chem., 2018, 2348, 810-815.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of [(2R,3R,4R,5R,6R)-5-acetamido-6-[2-[2-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[(4S)-5-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydropyran-2-yl]oxyethoxy]ethylamino]-4-[[4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxycyclohexanecarbonyl]amino]-5-oxo-pentanoyl]amino]-5-oxo-pentanoyl]amino]ethoxy]ethoxy]-3,4-diacetoxy-tetrahydropyran-2-yl]methyl acetate Using HRMS and NMR". Chemosphere, 2011, 2465, (10), 579-595.

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