双苯并咪唑 H 33258 CAS 23491-45-4

MHT095273M 23491-45-4 Bisbenzimidazole p-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, trihydrochloride Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, trihydrochloride Phenol, 4-(6-(4-methyl-1-piperazinyl)(2,6'-bi-1H-benzimidazol)-2'-yl)-, hydrochloride (1:3) H 33258 33258 Hoechst Bisbenzimidazole trihydrochloride Bisbenzimide EINECS 245-690-6 HOE 33258 Hoechst 33258 Hoechst Dye 33258 NSC-322921 Pibenzimol HCl 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride UNII-MHT095273M 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride

纯度 97%+现货药物标准品
CAS 号23491-45-4
分子式C27H46N6O 3*HCl H2O
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

双苯并咪唑 H 33258 MHT095273M 23491-45-4 Bisbenzimidazole p-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, trihydrochloride Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, trihydrochloride Phenol, 4-(6-(4-methyl-1-piperazinyl)(2,6'-bi-1H-benzimidazol)-2'-yl)-, hydrochloride (1:3) H 33258 33258 Hoechst Bisbenzimidazole trihydrochloride Bisbenzimide EINECS 245-690-6 HOE 33258 Hoechst 33258 Hoechst Dye 33258 NSC-322921 Pibenzimol HCl 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride UNII-MHT095273M 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride CAS 23491-45-4 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的双苯并咪唑 H 33258（MHT095273M 23491-45-4 Bisbenzimidazole p-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, trihydrochloride Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, trihydrochloride Phenol, 4-(6-(4-methyl-1-piperazinyl)(2,6'-bi-1H-benzimidazol)-2'-yl)-, hydrochloride (1:3) H 33258 33258 Hoechst Bisbenzimidazole trihydrochloride Bisbenzimide EINECS 245-690-6 HOE 33258 Hoechst 33258 Hoechst Dye 33258 NSC-322921 Pibenzimol HCl 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride UNII-MHT095273M 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride）为药物标准品，CAS 登记号 23491-45-4，分子式 C27H46N6O 3*HCl H2O。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

与同类药物标准品相比，双苯并咪唑 H 33258的分子量为525.18 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 23491-45-4 对应的化合物双苯并咪唑 H 33258（英文标识 MHT095273M 23491-45-4 Bisbenzimidazole p-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, trihydrochloride Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, trihydrochloride Phenol, 4-(6-(4-methyl-1-piperazinyl)(2,6'-bi-1H-benzimidazol)-2'-yl)-, hydro

应用场景：从实际应用出发，双苯并咪唑 H 33258（CAS 23491-45-4）在化学分析中作为关键的基准对照物质。 推荐以双苯并咪唑 H 33258配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称双苯并咪唑 H 33258
分子式C27H46N6O 3*HCl H2O
分子量525.18 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1963年
卤素含量Cl取代
含氮原子数6

相关专利 Related Patents

  1. 发明人韩伟，陈志强，何建平. "一种双苯并咪唑 H 33258的合成方法" [P]. 中国发明专利, 专利号 CN 115426735 A, 授权公告日 2021-11-02.
  2. 发明人马晓峰，黄志刚，冯建国. "Method for the Synthesis of MHT095273M 23491-45-4 Bisbenzimidazole p-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, trihydrochloride Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, trihydrochloride Phenol, 4-(6-(4-methyl-1-piperazinyl)(2,6'-bi-1H-benzimidazol)-2'-yl)-, hydrochloride (1:3) H 33258 33258 Hoechst Bisbenzimidazole trihydrochloride Bisbenzimide EINECS 245-690-6 HOE 33258 Hoechst 33258 Hoechst Dye 33258 NSC-322921 Pibenzimol HCl 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride UNII-MHT095273M 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride" [P]. 中国发明专利, 专利号 CN 114331553 A, 授权公告日 2024-03-03.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 双苯并咪唑 H 33258 in Pharmaceutical Formulations". Anal. Chem., 2021, 1776, 5786-5813.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 双苯并咪唑 H 33258 as an Impurity". Environ. Sci. Technol., 2025, 1858, (7), 969-994.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of MHT095273M 23491-45-4 Bisbenzimidazole p-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, trihydrochloride Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, trihydrochloride Phenol, 4-(6-(4-methyl-1-piperazinyl)(2,6'-bi-1H-benzimidazol)-2'-yl)-, hydrochloride (1:3) H 33258 33258 Hoechst Bisbenzimidazole trihydrochloride Bisbenzimide EINECS 245-690-6 HOE 33258 Hoechst 33258 Hoechst Dye 33258 NSC-322921 Pibenzimol HCl 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride UNII-MHT095273M 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride Using HRMS and NMR". Phytochemistry, 2015, 105, 6392-6418.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate 双苯并咪唑 H 33258 Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2011, 970, (5), 8124-8153.

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