2-羟基苯硼酸频哪醇酯 CAS 269409-97-4
2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2yl)-phenol 2-hydroxyphenylboronic acid, pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 2-Hydroxyphenylboronic acid pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)phenol 2-hydroxybenzeneboronic acid, pinacol ester phenol, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 269409-97-4
| CAS 号 | 269409-97-4 |
| 分子式 | C12H23BO3 |
| 分子量 | 226.12 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
2-羟基苯硼酸频哪醇酯（2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2yl)-phenol 2-hydroxyphenylboronic acid, pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 2-Hydroxyphenylboronic acid pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)phenol 2-hydroxybenzeneboronic acid, pinacol ester phenol, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 269409-97-4）是药物分析与质量控制领域常用的药物标准品，CAS 号 269409-97-4。分子式 C12H23BO3，分子量 226.12。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-羟基苯硼酸频哪醇酯在内的目标物的控制。 化学式为 C12H23BO3 的2-羟基苯硼酸频哪醇酯（2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2yl)-phenol 2-hydroxyphenylboronic acid, pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 2-Hydroxyphenylboronic acid pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)phenol 2-hydroxybenzeneboronic acid, pinacol ester phenol, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 269409-97-4），其CAS登记号是 269409-97-4，分子量为 226.12 g/mol。 受分子结构中羧酸类，含羟基，含醚键的
应用场景：针对化学分析用途，2-羟基苯硼酸频哪醇酯（2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2yl)-phenol 2-hydroxyphenylboronic acid, pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 2-Hydroxyphenylboronic acid pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)phenol 2-hydroxybenzeneboronic acid, pin
理化性质 Physical & Chemical Properties
| 中文名称 | 2-羟基苯硼酸频哪醇酯 |
| 分子式 | C12H23BO3 |
| 分子量 | 226.12 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，密封防潮 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.5 |
| CAS登记年份（估） | 2025年 |
相关专利 Related Patents
- 发明人朱建伟，马晓峰，张德明. "一种2-羟基苯硼酸频哪醇酯的合成方法" [P]. 中国发明专利, 专利号 CN 111529049 B, 授权公告日 2017-01-17.
- Park J H, Chen K W, Schröder R. "Method for the Synthesis of 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2yl)-phenol 2-hydroxyphenylboronic acid, pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 2-Hydroxyphenylboronic acid pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)phenol 2-hydroxybenzeneboronic acid, pinacol ester phenol, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 269409-97-4" [P]. US Patent, US 10521855 B2, 2023-11-16.
参考文献 Literature
- Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 2-羟基苯硼酸频哪醇酯 in Pharmaceutical Formulations". Anal. Chem., 2016, 1128, 6954-6971.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-羟基苯硼酸频哪醇酯 as an Impurity". Anal. Chim. Acta, 2020, 1181, (7), 7950-7953.
- Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2yl)-phenol 2-hydroxyphenylboronic acid, pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 2-Hydroxyphenylboronic acid pinacol ester 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)phenol 2-hydroxybenzeneboronic acid, pinacol ester phenol, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 269409-97-4 Using HRMS and NMR". J. Sep. Sci., 2017, 792, 4391-4414.
- Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 2-羟基苯硼酸频哪醇酯 Profile in Drug Substances According to ICH Guidelines". Molecules, 2012, 497, (6), 4717-4742.
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