4-Chloro-2,8-dimethylquinoline CAS 32314-39-9

(3ar,4as,7s,7as,8r,9ar)-4a,8-dimethyl-3-methylidene-2,5-dioxododecahydroazuleno[6,5-b]furan-7-yl 6-o-acetyl-|A-d-glucopyranoside 32314-39-9 KST-1A3794

纯度 97%+现货药物标准品
CAS 号32314-39-9
分子式C11H20ClN
分子量201.74 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-Chloro-2,8-dimethylquinoline (3ar,4as,7s,7as,8r,9ar)-4a,8-dimethyl-3-methylidene-2,5-dioxododecahydroazuleno[6,5-b]furan-7-yl 6-o-acetyl-|A-d-glucopyranoside 32314-39-9 KST-1A3794 CAS 32314-39-9 结构式 Chemical Structure

产品介绍 Description

CAS 32314-39-9 对应的4-Chloro-2,8-dimethylquinoline（(3ar,4as,7s,7as,8r,9ar)-4a,8-dimethyl-3-methylidene-2,5-dioxododecahydroazuleno[6,5-b]furan-7-yl 6-o-acetyl-|A-d-glucopyranoside 32314-39-9 KST-1A3794）为 CATO 佳途药物标准品产品线成员。分子式 C11H20ClN，分子量 201.74。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

化学式为 C11H20ClN 的4-Chloro-2,8-dimethylquinoline（(3ar,4as,7s,7as,8r,9ar)-4a,8-dimethyl-3-methylidene-2,5-dioxododecahydroazuleno6,5-bfuran-7-yl 6-o-acetyl-|A-d-glucopyranoside 32314-39-9 KST-1A3794），其CAS登记号是 32314-39-9，分子量为 201.74 g/mol。 4-Chloro-2,8-dimethylquinoline（C11H20ClN）含有含氰基，含氯取代。卤素取代增加了化合物的密度和沸点，较高的碳氢比使其脂溶性较好，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 在质量保证方面，4-Chloro-2

应用场景：针对化学分析用途，4-Chloro-2,8-dimethylquinoline（(3ar,4as,7s,7as,8r,9ar)-4a,8-dimethyl-3-methylidene-2,5-dioxododecahydroazuleno 6,5-b furan-7-yl 6-o-acetyl-|A-d-glucopyranoside 32314-39-9 KST-1A3794）是具有明确定量溯源的认证级对照品。 推荐以4-Chloro-2,8-dimethylquinoline配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释

理化性质 Physical & Chemical Properties

中文名称4-Chloro-2,8-dimethylquinoline
分子式C11H20ClN
分子量201.74 g/mol
外观形态白色至类白色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1966年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Fischer A B, Johnson M A, Patel M V. "一种4-Chloro-2,8-dimethylquinoline的合成方法" [P]. US Patent, US 10105113 B2, 2021-01-22.
  2. Nielsen H, Martínez F, Sørensen M. "Method for the Synthesis of (3ar,4as,7s,7as,8r,9ar)-4a,8-dimethyl-3-methylidene-2,5-dioxododecahydroazuleno[6,5-b]furan-7-yl 6-o-acetyl-|A-d-glucopyranoside 32314-39-9 KST-1A3794" [P]. European Patent, EP 3048519 A1, 2021-11-28.
  3. Johansson L, Martínez F, Schröder R. "A Process for Preparing High-Purity (3ar,4as,7s,7as,8r,9ar)-4a,8-dimethyl-3-methylidene-2,5-dioxododecahydroazuleno[6,5-b]furan-7-yl 6-o-acetyl-|A-d-glucopyranoside 32314-39-9 KST-1A3794" [P]. European Patent, EP 3158647 A1, 2023-03-03.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 4-Chloro-2,8-dimethylquinoline in Pharmaceutical Formulations". Environ. Sci. Technol., 2016, 887, 909-920.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-Chloro-2,8-dimethylquinoline as an Impurity". J. Chromatogr. A, 2021, 2207, 3774-3781.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of (3ar,4as,7s,7as,8r,9ar)-4a,8-dimethyl-3-methylidene-2,5-dioxododecahydroazuleno[6,5-b]furan-7-yl 6-o-acetyl-|A-d-glucopyranoside 32314-39-9 KST-1A3794 Using HRMS and NMR". Sci. Total Environ., 2015, 371, (11), 2770-2784.

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