(±)-3-甲基-2-氧戊酸 钠盐 CAS 3715-31-9

产品介绍 Description

本产品为药物标准品(±)-3-甲基-2-氧戊酸 钠盐（( inverted exclamation markA)-3-Methyl-2-oxovaleric acid sodium salt ( inverted exclamation markA)-Sodium 3-methyl-2-oxovalerate 2-Oxo-3-methylpentanoic Acid Sodium Salt 3-Methyl-2-oxopentanoic acid sodium salt 3-Methyl-2-oxovaleric Acid Sodium Salt 3715-31-9 DL-|A-Keto-|A-methylvaleric acid sodium salt Ketoisoleucine sodium salt Sodium 3-methyl-2-oxopentanoate Sodium 3-methyl-2-oxovalerate Sodium |A-Keto-|A-methylvalerate，CAS 3715-31-9），分子式 C6H9O3 Na。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C6H9O3 Na 的(±)-3-甲基-2-氧戊酸 钠盐（( inverted exclamation markA)-3-Methyl-2-oxovaleric acid sodium salt ( inverted exclamation markA)-Sodium 3-methyl-2-oxovalerate 2-Oxo-3-methylpentanoic Acid Sodium Salt 3-Methyl-2-oxopentanoic acid sodium salt 3-Methyl-2-oxovaleric Acid Sodium Salt 3715-31-9 DL-|A-Keto-|A-methylvaleric acid sodium salt Ketoisoleucine sodium salt Sodium 3-methyl-2-oxopentanoate Sodium 3-methyl-2-oxov

应用场景：在化学分析实验室中，(±)-3-甲基-2-氧戊酸 钠盐（CAS 3715-31-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(±)-3-甲基-2-氧戊酸 钠盐配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

相关专利 Related Patents

1. 发明人唐晓军，刘建华，赵玉洁. "一种(±)-3-甲基-2-氧戊酸 钠盐的合成方法" [P]. 中国发明专利, 专利号 CN 112681295 B, 授权公告日 2022-02-24.
2. Martínez F, Lefèvre J P, Schröder R. "Method for the Synthesis of ( inverted exclamation markA)-3-Methyl-2-oxovaleric acid sodium salt ( inverted exclamation markA)-Sodium 3-methyl-2-oxovalerate 2-Oxo-3-methylpentanoic Acid Sodium Salt 3-Methyl-2-oxopentanoic acid sodium salt 3-Methyl-2-oxovaleric Acid Sodium Salt 3715-31-9 DL-|A-Keto-|A-methylvaleric acid sodium salt Ketoisoleucine sodium salt Sodium 3-methyl-2-oxopentanoate Sodium 3-methyl-2-oxovalerate Sodium |A-Keto-|A-methylvalerate" [P]. European Patent, EP 3939452 A1, 2021-01-16.
3. 发明人陈志强，杨光，冯建国. "A Process for Preparing High-Purity ( inverted exclamation markA)-3-Methyl-2-oxovaleric acid sodium salt ( inverted exclamation markA)-Sodium 3-methyl-2-oxovalerate 2-Oxo-3-methylpentanoic Acid Sodium Salt 3-Methyl-2-oxopentanoic acid sodium salt 3-Methyl-2-oxovaleric Acid Sodium Salt 3715-31-9 DL-|A-Keto-|A-methylvaleric acid sodium salt Ketoisoleucine sodium salt Sodium 3-methyl-2-oxopentanoate Sodium 3-methyl-2-oxovalerate Sodium |A-Keto-|A-methylvalerate" [P]. 中国发明专利, 专利号 CN 110986878 A, 授权公告日 2019-11-17.

参考文献 Literature

1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of (±)-3-甲基-2-氧戊酸 钠盐 in Pharmaceutical Formulations". Chemosphere, 2015, 2417, (7), 8714-8719.
2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of (±)-3-甲基-2-氧戊酸 钠盐 as an Impurity". J. Agric. Food Chem., 2011, 502, (1), 3770-3788.
3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of ( inverted exclamation markA)-3-Methyl-2-oxovaleric acid sodium salt ( inverted exclamation markA)-Sodium 3-methyl-2-oxovalerate 2-Oxo-3-methylpentanoic Acid Sodium Salt 3-Methyl-2-oxopentanoic acid sodium salt 3-Methyl-2-oxovaleric Acid Sodium Salt 3715-31-9 DL-|A-Keto-|A-methylvaleric acid sodium salt Ketoisoleucine sodium salt Sodium 3-methyl-2-oxopentanoate Sodium 3-methyl-2-oxovalerate Sodium |A-Keto-|A-methylvalerate Using HRMS and NMR". J. Chromatogr. A, 2017, 1490, 130-144.

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