(3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one CAS 379239-99-3
(3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one
| CAS 号 | 379239-99-3 |
| 分子式 | C16H15F3N2O3 |
| 分子量 | 340.30 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品(3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one（(3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one，CAS 379239-99-3），分子式 C16H15F3N2O3，分子量 340.30。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
在质量保证方面，(3E)-1,1,1-trifluoro-5-(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidenepent-3-en-2-one的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C16H15F3N2O3 的(3E)-1,1,1-trifluoro-5-(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidenepent-3-en-2-one（(3E)-1,1,1-trifluoro-5-(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidenepent-3-en-2-one），其CAS登记号是 379239-99-3，分子量为 340.30 g/mo
应用场景：(3E)-1,1,1-trifluoro-5- (2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene pent-3-en-2-one（(3E)-1,1,1-trifluoro-5- (2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene pent-3-en-2-one，CAS 379239-99-3）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以(3E)-1,1,1-trifluoro-5- (2Z)-1,3,3-trimethyl-6-nitro-2,
理化性质 Physical & Chemical Properties
| 中文名称 | (3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one |
| 分子式 | C16H15F3N2O3 |
| 分子量 | 340.30 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 9.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 2025年 |
| 卤素含量 | F取代 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- Schröder R, Johansson L, Nielsen H. "一种(3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one的合成方法" [P]. European Patent, EP 3244065 A1, 2018-03-20.
- 发明人冯建国，高志强，赵玉洁. "Method for the Synthesis of (3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one" [P]. 中国发明专利, 专利号 CN 110062423 B, 授权公告日 2015-07-01.
- Anderson J P, Williams B T, Kumar R. "A Process for Preparing High-Purity (3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one" [P]. US Patent, US 11914360 B2, 2018-01-14.
参考文献 Literature
- Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of (3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one in Pharmaceutical Formulations". Anal. Chim. Acta, 2012, 999, (12), 4925-4955.
- Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of (3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one as an Impurity". Environ. Sci. Technol., 2013, 172, (4), 2737-2766.
- Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of (3E)-1,1,1-trifluoro-5-[(2Z)-1,3,3-trimethyl-6-nitro-2,3-dihydro-1H-indol-2-ylidene]pent-3-en-2-one Using HRMS and NMR". Biomed. Chromatogr., 2018, 1036, (10), 32-41.
Related E Standards 同系列产品
- 4,4,4-三氟-1-(噻吩-2-基)-2-(2-(间甲苯基)亚肼基)丁烷-1,3-二酮 (CAS 263890-70-6)
- 2,2,2-trifluoro-1-[(3R,4R)-4-methyl-3-[methyl({1H-pyrrolo[2,3-b]pyridin-4-yl})amino]piperidin-1-yl]ethan-1-one (CAS 894359-17-2)
- 1,1,1-Trifluoro-4,4-bis(phenylthio)but-3-en-2-one (CAS 54083-61-3)
- 2,2,2-Trifluoro-1-(1-methyl-1H-indol-3-yl)ethyl thiophene-2-carboxylate (CAS 478079-29-7)
- 2,2,2-Trifluoro-N-(3-(phenylethynyl)quinoxalin-2-yl)acetamide (CAS 676543-67-2)
- 4,4,4-Trifluoro-1-(4-iodophenyl)butane-1,3-dione (CAS 685892-12-0)
- 1,2,3-Trifluoro-4-[(trans,trans)-4-propyl[1,1-bicyclohexyl]-4-yl]benzene (CAS 139056-62-5)
- 2,2,2-Trifluoro-N-(4-(2,2,2-trifluoroacetyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-5-yl)acetamide (CAS 1794736-68-7)
推荐产品 Recommended Standards
- (1R,2R,6S)-4-[3-(Trifluoromethyl)phenyl]-7-oxa-4,8-diazatricyclo[6.4.0.0^{2,6}]dodecane-3,5-dione (CAS 318247-21-1)
- (3S,4R,5R)-5-((Benzoyloxy)methyl)-4-fluorotetrahydrofuran-2,3-diyl diacetate (CAS 2316640-49-8)
- 1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose (CAS 159099-24-8)
- 5-((2-Aminoethyl)amino)-6-methyl-1,2,4-triazin-3-ol (CAS 496033-05-7)
- 1-(3-Chlorophenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid (CAS 478063-67-1)
- 3-Pentanone p-Toluenesulfonylhydrazone (CAS 28495-72-9)
- 1-(But-3-en-1-yl)-1H-1,2,4-triazole (CAS 138825-18-0)
- 4-Oxo-4-(1,4-dioxa-8-azaspiro[4.5]Decan-8-yl)butanoic acid (CAS 883550-05-8)
- Methyl 3-hydroxy-4-nitro-2-naphthoate (CAS 5394-81-0)
- 81988-89-8 UH11FDQ454 Ramoplanin A(sub 3) Ramoplanin A3 (S)-2-(3-Chloro-4-hydroxyphenyl)-N-(N(sup 2)-((2Z,4Z)-8-methyl-2,4-nonadienoyl)-(S)-asparaginyl-(2S,3S)-3-hydroxyasparaginyl-(R)-2-(p-hydroxyphenyl)glycyl-(R)-ornithyl-(2R,3R)-allothreonyl-2-(p-hydroxyphenyl)glycyl-2-(p-hydroxyphenyl)glycyl-(2S,3S)-allothreonyl-(S)-phenylalanyl-(R)-ornithyl-(S)-2-(p-((2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranosyl)oxy)phenyl)glycyl-(2R,3R)-allothreonyl-(S)-2-(p-hydroxyphenyl)glycylglycyl-(S)-leucyl-(R)-alanyl)glycine psi1-lactone Ramoplanin A 1 (peptide moiety), 1-(N(sup 2)-methyl-1-oxo-2,4-nonadienyl)-L-asparagine)-11-(L-2-(4-((2-O-alpha-D-mannopyranosyl-alpha-D-mannopyranosyl)oxy)phenyl)glycine)-, (Z,Z)- UNII-UH11FDQ454 (CAS 81988-89-8)
为什么选择 CATO 佳途？
- ISO 17034 / CNAS / ANAB 三重认证标准物质生产商
- 130,000+ 品种现货库存，支持 COA 定制
- 专业技术支持：+86 13829788188 / jacky.chen@cato-chem.com
- 全球 10,000+ 客户信赖之选