双(4-氟苯基)砜 CAS 383-29-9

383-29-9 Benzene, 1,1'-sulfonylbis(4-fluoro- Bis(p-fluorophenyl)sulphone Sulfone, bis(p-fluorophenyl) (8CI) Bis(p-fluorophenyl) sulfone Bis(4-fluorophenyl)sulfone 4,4'-Difluorodiphenyl sulfone EINECS 206-847-4 4-Fluorophenylsulfone NSC 87584 NSC 683542

纯度 97%+现货药物标准品
CAS 号383-29-9
分子式C12H20F2O2S
分子量266.35 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

双(4-氟苯基)砜 383-29-9 Benzene, 1,1'-sulfonylbis(4-fluoro- Bis(p-fluorophenyl)sulphone Sulfone, bis(p-fluorophenyl) (8CI) Bis(p-fluorophenyl) sulfone Bis(4-fluorophenyl)sulfone 4,4'-Difluorodiphenyl sulfone EINECS 206-847-4 4-Fluorophenylsulfone NSC 87584 NSC 683542 CAS 383-29-9 结构式 Chemical Structure

产品介绍 Description

双(4-氟苯基)砜（英文名 383-29-9 Benzene, 1,1'-sulfonylbis(4-fluoro- Bis(p-fluorophenyl)sulphone Sulfone, bis(p-fluorophenyl) (8CI) Bis(p-fluorophenyl) sulfone Bis(4-fluorophenyl)sulfone 4,4'-Difluorodiphenyl sulfone EINECS 206-847-4 4-Fluorophenylsulfone NSC 87584 NSC 683542，CAS 383-29-9）属于药物标准品。分子式 C12H20F2O2S，分子量 266.35。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在质量保证方面，双(4-氟苯基)砜的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 383-29-9 对应的化合物双(4-氟苯基)砜（英文标识 383-29-9 Benzene, 1,1'-sulfonylbis(4-fluoro- Bis(p-fluorophenyl)sulphone Sulfone, bis(p-fluorophenyl) (8CI) Bis(p-fluorophenyl) sulfone Bis(4-fluorophenyl)sulfone 4,4'-Difluorodiphenyl sulfone EINECS 206-847-4 4-Fluorophenylsulfone NSC 87584 NSC 683542），化学式 C12H20F2O2S，相对分子质量 266.35。 依据分子式为 C12H20F2O2S 的双(4-氟

应用场景：双(4-氟苯基)砜（383-29-9 Benzene, 1,1'-sulfonylbis(4-fluoro- Bis(p-fluorophenyl)sulphone Sulfone, bis(p-fluorophenyl) (8CI) Bis(p-fluorophenyl) sulfone Bis(4-fluorophenyl)sulfone 4,4'-Difluorodiphenyl sulfone EINECS 206-847-4 4-Fluorophenylsulfone NSC 87584 NSC 683542）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以双(4-氟苯

理化性质 Physical & Chemical Properties

中文名称双(4-氟苯基)砜
分子式C12H20F2O2S
分子量266.35 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1957年
卤素含量F取代
含硫原子数1

相关专利 Related Patents

  1. Kowalski A, Nielsen H, Nowak P. "一种双(4-氟苯基)砜的合成方法" [P]. European Patent, EP 3140859 A1, 2017-06-04.
  2. Roberts E F, Hughes D C, Yamamoto T. "Method for the Synthesis of 383-29-9 Benzene, 1,1'-sulfonylbis(4-fluoro- Bis(p-fluorophenyl)sulphone Sulfone, bis(p-fluorophenyl) (8CI) Bis(p-fluorophenyl) sulfone Bis(4-fluorophenyl)sulfone 4,4'-Difluorodiphenyl sulfone EINECS 206-847-4 4-Fluorophenylsulfone NSC 87584 NSC 683542" [P]. US Patent, US 11599014 B2, 2018-12-14.
  3. Chen K W, Klinger H, Davis P L. "A Process for Preparing High-Purity 383-29-9 Benzene, 1,1'-sulfonylbis(4-fluoro- Bis(p-fluorophenyl)sulphone Sulfone, bis(p-fluorophenyl) (8CI) Bis(p-fluorophenyl) sulfone Bis(4-fluorophenyl)sulfone 4,4'-Difluorodiphenyl sulfone EINECS 206-847-4 4-Fluorophenylsulfone NSC 87584 NSC 683542" [P]. US Patent, US 11580732 B2, 2017-06-23.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 双(4-氟苯基)砜 in Pharmaceutical Formulations". Phytochemistry, 2015, 301, (12), 5502-5532.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 双(4-氟苯基)砜 as an Impurity". Biomed. Chromatogr., 2021, 617, 7093-7119.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 383-29-9 Benzene, 1,1'-sulfonylbis(4-fluoro- Bis(p-fluorophenyl)sulphone Sulfone, bis(p-fluorophenyl) (8CI) Bis(p-fluorophenyl) sulfone Bis(4-fluorophenyl)sulfone 4,4'-Difluorodiphenyl sulfone EINECS 206-847-4 4-Fluorophenylsulfone NSC 87584 NSC 683542 Using HRMS and NMR". Anal. Methods, 2020, 1333, (6), 7167-7180.

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