1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinecarboxylic acid CAS 406476-31-1

1-(5-(trifluoromethyl)-2-pyridyl)piperidine-4-carboxylic acid 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)pyrid-2-yl]piperidine-4-carboxylic acid 406476-31-1 5'-trifluoromethyl-3,4,5,6-tetrahydro-2h-[1,2']bipyridinyl-4-carboxylic acid n-[5'-(trifluoromethyl)pyridin-2'-yl]piperidine-4-carboxylic acid

纯度 97%+现货药物标准品
CAS 号406476-31-1
分子式C12H19F3N2O2
分子量280.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinecarboxylic acid 1-(5-(trifluoromethyl)-2-pyridyl)piperidine-4-carboxylic acid 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)pyrid-2-yl]piperidine-4-carboxylic acid 406476-31-1 5'-trifluoromethyl-3,4,5,6-tetrahydro-2h-[1,2']bipyridinyl-4-carboxylic acid n-[5'-(trifluoromethyl)pyridin-2'-yl]piperidine-4-carboxylic acid CAS 406476-31-1 结构式 Chemical Structure

产品介绍 Description

CAS 406476-31-1 对应的1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinecarboxylic acid（1-(5-(trifluoromethyl)-2-pyridyl)piperidine-4-carboxylic acid 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)pyrid-2-yl]piperidine-4-carboxylic acid 406476-31-1 5'-trifluoromethyl-3,4,5,6-tetrahydro-2h-[1,2']bipyridinyl-4-carboxylic acid n-[5'-(trifluoromethyl)pyridin-2'-yl]piperidine-4-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C12H19F3N2O2，分子量 280.29。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

化学式为 C12H19F3N2O2 的1-5-(Trifluoromethyl)-2-pyridinyl-4-piperidinecarboxylic acid（1-(5-(trifluoromethyl)-2-pyridyl)piperidine-4-carboxylic acid 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid 1-5-(Trifluoromethyl)pyridin-2-ylpiperidine-4-carboxylic acid 1-5-(trifluoromethyl)-2-pyridylpiperidine-4-carboxylic acid 1-5-(trifluoromethyl)pyrid-2-ylpiperidine-4-carboxylic acid 406476-31-1 5'-trifluoromethyl-3,4,5,6-tetrahydro-2h-1,2'bipyridinyl-4-carboxylic acid n-5'-(trifluo

应用场景：1- 5-(Trifluoromethyl)-2-pyridinyl -4-piperidinecarboxylic acid（1-(5-(trifluoromethyl)-2-pyridyl)piperidine-4-carboxylic acid 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid 1- 5-(Trifluoromethyl)pyridin-2-yl piperidine-4-carboxylic acid 1- 5-(trifluoromethyl)-2-pyridyl piperidine-4-

理化性质 Physical & Chemical Properties

中文名称1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinecarboxylic acid
分子式C12H19F3N2O2
分子量280.29 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）2025年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. 发明人胡光，马晓峰，周伟. "一种1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinecarboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 109423212 A, 授权公告日 2024-04-17.
  2. 发明人刘建华，李文辉，陈志强. "Method for the Synthesis of 1-(5-(trifluoromethyl)-2-pyridyl)piperidine-4-carboxylic acid 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)pyrid-2-yl]piperidine-4-carboxylic acid 406476-31-1 5'-trifluoromethyl-3,4,5,6-tetrahydro-2h-[1,2']bipyridinyl-4-carboxylic acid n-[5'-(trifluoromethyl)pyridin-2'-yl]piperidine-4-carboxylic acid" [P]. 中国发明专利, 专利号 CN 117128759 B, 授权公告日 2019-03-05.
  3. 发明人郑宇鹏，林芳，唐晓军. "A Process for Preparing High-Purity 1-(5-(trifluoromethyl)-2-pyridyl)piperidine-4-carboxylic acid 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)pyrid-2-yl]piperidine-4-carboxylic acid 406476-31-1 5'-trifluoromethyl-3,4,5,6-tetrahydro-2h-[1,2']bipyridinyl-4-carboxylic acid n-[5'-(trifluoromethyl)pyridin-2'-yl]piperidine-4-carboxylic acid" [P]. 中国发明专利, 专利号 CN 117653167 B, 授权公告日 2020-01-24.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinecarboxylic acid in Pharmaceutical Formulations". Biomed. Chromatogr., 2013, 488, (7), 6637-6641.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-[5-(Trifluoromethyl)-2-pyridinyl]-4-piperidinecarboxylic acid as an Impurity". J. Agric. Food Chem., 2025, 735, 9484-9509.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 1-(5-(trifluoromethyl)-2-pyridyl)piperidine-4-carboxylic acid 1-(5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid 1-[5-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)-2-pyridyl]piperidine-4-carboxylic acid 1-[5-(trifluoromethyl)pyrid-2-yl]piperidine-4-carboxylic acid 406476-31-1 5'-trifluoromethyl-3,4,5,6-tetrahydro-2h-[1,2']bipyridinyl-4-carboxylic acid n-[5'-(trifluoromethyl)pyridin-2'-yl]piperidine-4-carboxylic acid Using HRMS and NMR". Chromatographia, 2019, 140, (12), 1936-1955.

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