2-morpholin-4-ylethanethiol CAS 4542-46-5

4542-46-5 Ethanethiol, morpholino- 4-Morpholineethanethiol Morpholin-4-ylethylthiol 4-27-00-00106 (Beilstein Handbook Reference) BRN 0104376 EINECS 224-893-3 4-(2-Mercaptoethyl)morpholine Morpholine, 4-mercaptoethyl- 2-Morpholinoethanethiol 2-(4-Morpholinyl)ethanethiol N-Morpholylcysteamin [German] N-Morpholylcysteamin

纯度 97%+现货药物标准品
CAS 号4542-46-5
分子式C6H13NOS
分子量147.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-morpholin-4-ylethanethiol 4542-46-5 Ethanethiol, morpholino- 4-Morpholineethanethiol Morpholin-4-ylethylthiol 4-27-00-00106 (Beilstein Handbook Reference) BRN 0104376 EINECS 224-893-3 4-(2-Mercaptoethyl)morpholine Morpholine, 4-mercaptoethyl- 2-Morpholinoethanethiol 2-(4-Morpholinyl)ethanethiol N-Morpholylcysteamin [German] N-Morpholylcysteamin CAS 4542-46-5 结构式 Chemical Structure

产品介绍 Description

CAS 4542-46-5 对应的2-morpholin-4-ylethanethiol（4542-46-5 Ethanethiol, morpholino- 4-Morpholineethanethiol Morpholin-4-ylethylthiol 4-27-00-00106 (Beilstein Handbook Reference) BRN 0104376 EINECS 224-893-3 4-(2-Mercaptoethyl)morpholine Morpholine, 4-mercaptoethyl- 2-Morpholinoethanethiol 2-(4-Morpholinyl)ethanethiol N-Morpholylcysteamin [German] N-Morpholylcysteamin）为 CATO 佳途药物标准品产品线成员。分子式 C6H13NOS，分子量 147.24。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

2-morpholin-4-ylethanethiol的产生途径与其化学式中酰胺类，含硫有机，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C6H13NOS 的2-morpholin-4-ylethanethiol（4542-46-5 Ethanethiol, morpholino- 4-Morpholineethanethiol Morpholin-4-ylethylthiol 4-27-00-00106 (Beilstein Handbook Reference) BRN 0104376 EINECS 224-893-3 4-(2-Mercaptoethyl)morpholine Morpholine, 4-mercaptoethyl- 2-Morpholinoethanethiol 2-(4-Morpholinyl)ethanethiol N-Morpholylcysteamin German N-Morpholylcysteamin），其CAS登记号是 4542-46-5，分子量为 147.24 g/mol。 从化学结构

应用场景：2-morpholin-4-ylethanethiol（4542-46-5 Ethanethiol, morpholino- 4-Morpholineethanethiol Morpholin-4-ylethylthiol 4-27-00-00106 (Beilstein Handbook Reference) BRN 0104376 EINECS 224-893-3 4-(2-Mercaptoethyl)morpholine Morpholine, 4-mercaptoethyl- 2-Morpholinoethanethiol 2-(4-Morpholinyl)ethanethiol N-

理化性质 Physical & Chemical Properties

中文名称2-morpholin-4-ylethanethiol
分子式C6H13NOS
分子量147.24 g/mol
外观形态白色至类白色液体。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1958年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. 发明人钱学锋，赵玉洁，罗永刚. "一种2-morpholin-4-ylethanethiol的合成方法" [P]. 中国发明专利, 专利号 CN 111281813 B, 授权公告日 2021-11-22.
  2. 发明人杨光，钱学锋，李文辉. "Method for the Synthesis of 4542-46-5 Ethanethiol, morpholino- 4-Morpholineethanethiol Morpholin-4-ylethylthiol 4-27-00-00106 (Beilstein Handbook Reference) BRN 0104376 EINECS 224-893-3 4-(2-Mercaptoethyl)morpholine Morpholine, 4-mercaptoethyl- 2-Morpholinoethanethiol 2-(4-Morpholinyl)ethanethiol N-Morpholylcysteamin [German] N-Morpholylcysteamin" [P]. 中国发明专利, 专利号 CN 110301076 A, 授权公告日 2023-01-16.
  3. 发明人钱学锋，高志强，沈红梅. "A Process for Preparing High-Purity 4542-46-5 Ethanethiol, morpholino- 4-Morpholineethanethiol Morpholin-4-ylethylthiol 4-27-00-00106 (Beilstein Handbook Reference) BRN 0104376 EINECS 224-893-3 4-(2-Mercaptoethyl)morpholine Morpholine, 4-mercaptoethyl- 2-Morpholinoethanethiol 2-(4-Morpholinyl)ethanethiol N-Morpholylcysteamin [German] N-Morpholylcysteamin" [P]. 中国发明专利, 专利号 CN 110528250 A, 授权公告日 2018-10-25.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 2-morpholin-4-ylethanethiol in Pharmaceutical Formulations". Environ. Sci. Technol., 2021, 1314, (4), 1098-1119.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-morpholin-4-ylethanethiol as an Impurity". Molecules, 2022, 1564, (2), 1608-1632.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 4542-46-5 Ethanethiol, morpholino- 4-Morpholineethanethiol Morpholin-4-ylethylthiol 4-27-00-00106 (Beilstein Handbook Reference) BRN 0104376 EINECS 224-893-3 4-(2-Mercaptoethyl)morpholine Morpholine, 4-mercaptoethyl- 2-Morpholinoethanethiol 2-(4-Morpholinyl)ethanethiol N-Morpholylcysteamin [German] N-Morpholylcysteamin Using HRMS and NMR". Anal. Chem., 2020, 1567, (5), 4656-4680.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 2-morpholin-4-ylethanethiol Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2025, 586, (9), 5256-5286.

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