2-(methylthio)pyrimidin-4-amine CAS 2183-66-6

2-(Methylthio)pyrimidin-4-amine 2-methylsulfanylpyrimidin-4-amine 2183-66-6 4-Amino-2-methylthiopyrimidine 4-amino-2-methylsulfanylpyrimidine 4-pyrimidinamine, 2-(methylthio)- 4-pyrimidinamine, 2-(methylthio)- (9ci) [2-(methylthio)pyrimidin-4-yl]amine methylthiopyrimidinamine

纯度 97%+现货药物标准品
CAS 号2183-66-6
分子式C5H13N3S
分子量147.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(methylthio)pyrimidin-4-amine 2-(Methylthio)pyrimidin-4-amine 2-methylsulfanylpyrimidin-4-amine 2183-66-6 4-Amino-2-methylthiopyrimidine 4-amino-2-methylsulfanylpyrimidine 4-pyrimidinamine, 2-(methylthio)- 4-pyrimidinamine, 2-(methylthio)- (9ci) [2-(methylthio)pyrimidin-4-yl]amine methylthiopyrimidinamine CAS 2183-66-6 结构式 Chemical Structure

产品介绍 Description

2-(methylthio)pyrimidin-4-amine（2-(Methylthio)pyrimidin-4-amine 2-methylsulfanylpyrimidin-4-amine 2183-66-6 4-Amino-2-methylthiopyrimidine 4-amino-2-methylsulfanylpyrimidine 4-pyrimidinamine, 2-(methylthio)- 4-pyrimidinamine, 2-(methylthio)- (9ci) [2-(methylthio)pyrimidin-4-yl]amine methylthiopyrimidinamine，CAS 号 2183-66-6）是 CATO 佳途自主生产的药物标准品，分子式 C5H13N3S，分子量 147.24。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

2-(methylthio)pyrimidin-4-amine的产生途径与其化学式中含硫有机密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C5H13N3S 的2-(methylthio)pyrimidin-4-amine（2-(Methylthio)pyrimidin-4-amine 2-methylsulfanylpyrimidin-4-amine 2183-66-6 4-Amino-2-methylthiopyrimidine 4-amino-2-methylsulfanylpyrimidine 4-pyrimidinamine, 2-(methylthio)- 4-pyrimidinamine, 2-(methylthio)- (9ci) 2-(methylthio)pyrimidin-4-ylamine methylthiopyrimidinamine），其CAS登记号是 2183-66-6，分子量为 147.24 g/mol。 依据分子式为 C5H13N3S 的2-(methylthio)pyrimidin-4-amine结构特征，

应用场景：2-(methylthio)pyrimidin-4-amine（2-(Methylthio)pyrimidin-4-amine 2-methylsulfanylpyrimidin-4-amine 2183-66-6 4-Amino-2-methylthiopyrimidine 4-amino-2-methylsulfanylpyrimidine 4-pyrimidinamine, 2-(methylthio)- 4-pyrimidinamine, 2-(methylthio)- (9ci) 2-(methylthio)pyrimidin-4-yl amine methylthiopyrimi

理化性质 Physical & Chemical Properties

中文名称2-(methylthio)pyrimidin-4-amine
分子式C5H13N3S
分子量147.24 g/mol
外观形态白色至类白色液体。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. 发明人徐明华，刘建华，王建平. "一种2-(methylthio)pyrimidin-4-amine的合成方法" [P]. 中国发明专利, 专利号 CN 110542438 A, 授权公告日 2016-02-06.
  2. 发明人杨光，沈红梅，郑宇鹏. "Method for the Synthesis of 2-(Methylthio)pyrimidin-4-amine 2-methylsulfanylpyrimidin-4-amine 2183-66-6 4-Amino-2-methylthiopyrimidine 4-amino-2-methylsulfanylpyrimidine 4-pyrimidinamine, 2-(methylthio)- 4-pyrimidinamine, 2-(methylthio)- (9ci) [2-(methylthio)pyrimidin-4-yl]amine methylthiopyrimidinamine" [P]. 中国发明专利, 专利号 CN 111404020 B, 授权公告日 2019-06-02.
  3. 发明人何建平，罗永刚，刘建华. "A Process for Preparing High-Purity 2-(Methylthio)pyrimidin-4-amine 2-methylsulfanylpyrimidin-4-amine 2183-66-6 4-Amino-2-methylthiopyrimidine 4-amino-2-methylsulfanylpyrimidine 4-pyrimidinamine, 2-(methylthio)- 4-pyrimidinamine, 2-(methylthio)- (9ci) [2-(methylthio)pyrimidin-4-yl]amine methylthiopyrimidinamine" [P]. 中国发明专利, 专利号 CN 109820478 B, 授权公告日 2017-10-16.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(methylthio)pyrimidin-4-amine in Pharmaceutical Formulations". Food Chem., 2013, 2271, 4420-4423.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(methylthio)pyrimidin-4-amine as an Impurity". Talanta, 2020, 684, (8), 38-62.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 2-(Methylthio)pyrimidin-4-amine 2-methylsulfanylpyrimidin-4-amine 2183-66-6 4-Amino-2-methylthiopyrimidine 4-amino-2-methylsulfanylpyrimidine 4-pyrimidinamine, 2-(methylthio)- 4-pyrimidinamine, 2-(methylthio)- (9ci) [2-(methylthio)pyrimidin-4-yl]amine methylthiopyrimidinamine Using HRMS and NMR". J. Agric. Food Chem., 2021, 1454, 286-316.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 2-(methylthio)pyrimidin-4-amine Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2010, 2293, (5), 6902-6912.

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