鞘磷脂 CAS 475662-40-9

475662-40-9 N-tricosanoylsphing-4-enine-1-phosphocholine C23 Sphingomyelin N-(Tricosanoyl)-sphing-4-enine-1-phosphocholine SM(d18:1/23:0) Milk SM Sphingomyelin (Milk, Bovine) sphingomyelin-milk (2S,3R,4E)-3-hydroxy-2-(tricosanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate milk sphingomyelin CHEBI:83880

纯度 97%+现货药物标准品
CAS 号475662-40-9
分子式C46H93N2O6P
分子量801.21 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

鞘磷脂 475662-40-9 N-tricosanoylsphing-4-enine-1-phosphocholine C23 Sphingomyelin N-(Tricosanoyl)-sphing-4-enine-1-phosphocholine SM(d18:1/23:0) Milk SM Sphingomyelin (Milk, Bovine) sphingomyelin-milk (2S,3R,4E)-3-hydroxy-2-(tricosanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate milk sphingomyelin CHEBI:83880 CAS 475662-40-9 结构式 Chemical Structure

产品介绍 Description

鞘磷脂（英文名 475662-40-9 N-tricosanoylsphing-4-enine-1-phosphocholine C23 Sphingomyelin N-(Tricosanoyl)-sphing-4-enine-1-phosphocholine SM(d18:1/23:0) Milk SM Sphingomyelin (Milk, Bovine) sphingomyelin-milk (2S,3R,4E)-3-hydroxy-2-(tricosanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate milk sphingomyelin CHEBI:83880，CAS 475662-40-9）属于药物标准品。分子式 C46H93N2O6P，分子量 801.21。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

鞘磷脂的产生途径与其化学式中酰胺类，含磷酸酯基，羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 鞘磷脂（475662-40-9 N-tricosanoylsphing-4-enine-1-phosphocholine C23 Sphingomyelin N-(Tricosanoyl)-sphing-4-enine-1-phosphocholine SM(d18:1/23:0) Milk SM Sphingomyelin (Milk, Bovine) sphingomyelin-milk (2S,3R,4E)-3-hydroxy-2-(tricosanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate milk sphingomyelin CHEBI:83880），CAS注册编号 475662-40-9，化学分子式为 C46H93N2O6P，分子量 801.21 g/mol。 从化学结构特征来看，鞘磷脂的分子骨架中包含酰胺类，含磷酸酯基，羧酸类，含羟基，含醚键。

应用场景：鞘磷脂（475662-40-9 N-tricosanoylsphing-4-enine-1-phosphocholine C23 Sphingomyelin N-(Tricosanoyl)-sphing-4-enine-1-phosphocholine SM(d18:1/23:0) Milk SM Sphingomyelin (Milk, Bovine) sphingomyelin-milk (2S,3R,4E)-3-hydroxy-2-(tricosanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate milk

理化性质 Physical & Chemical Properties

中文名称鞘磷脂
分子式C46H93N2O6P
分子量801.21 g/mol
外观形态白色至类白色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.5
CAS登记年份（估）2025年
含氮原子数2

相关专利 Related Patents

  1. 发明人黄志刚，胡光，罗永刚. "一种鞘磷脂的合成方法" [P]. 中国发明专利, 专利号 CN 112884567 A, 授权公告日 2025-06-11.
  2. 发明人郭海燕，张德明，何建平. "Method for the Synthesis of 475662-40-9 N-tricosanoylsphing-4-enine-1-phosphocholine C23 Sphingomyelin N-(Tricosanoyl)-sphing-4-enine-1-phosphocholine SM(d18:1/23:0) Milk SM Sphingomyelin (Milk, Bovine) sphingomyelin-milk (2S,3R,4E)-3-hydroxy-2-(tricosanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate milk sphingomyelin CHEBI:83880" [P]. 中国发明专利, 专利号 CN 113358527 A, 授权公告日 2022-10-24.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 鞘磷脂 in Pharmaceutical Formulations". Biomed. Chromatogr., 2018, 473, (10), 4982-5010.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 鞘磷脂 as an Impurity". Rapid Commun. Mass Spectrom., 2020, 645, (12), 5963-5983.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 475662-40-9 N-tricosanoylsphing-4-enine-1-phosphocholine C23 Sphingomyelin N-(Tricosanoyl)-sphing-4-enine-1-phosphocholine SM(d18:1/23:0) Milk SM Sphingomyelin (Milk, Bovine) sphingomyelin-milk (2S,3R,4E)-3-hydroxy-2-(tricosanoylamino)octadec-4-en-1-yl 2-(trimethylazaniumyl)ethyl phosphate milk sphingomyelin CHEBI:83880 Using HRMS and NMR". Anal. Methods, 2020, 2016, 1555-1576.

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