CAS 5220-39-3
5220-39-3 11H-Cyclohepta(b)quinolin-11-one, 5,6,7,8,9,10-hexahydro- 5-21-08-00522 (Beilstein Handbook Reference) BRN 1529222 5,6,7,8,9,10-Hexahydro-11H-cyclohepta(b)quinolin-11-one 7,8,9,10-Tetrahydro-6H-cyclohepta(b)quinolin-11-one
| CAS 号 | 5220-39-3 |
| 分子式 | C14H15NO |
| 分子量 | 213.28 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CATO 佳途供应的（5220-39-3 11H-Cyclohepta(b)quinolin-11-one, 5,6,7,8,9,10-hexahydro- 5-21-08-00522 (Beilstein Handbook Reference) BRN 1529222 5,6,7,8,9,10-Hexahydro-11H-cyclohepta(b)quinolin-11-one 7,8,9,10-Tetrahydro-6H-cyclohepta(b)quinolin-11-one）为药物标准品，CAS 登记号 5220-39-3，分子式 C14H15NO，分子量 213.28。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括在内的目标物的控制。 化学式为 C14H15NO 的（5220-39-3 11H-Cyclohepta(b)quinolin-11-one, 5,6,7,8,9,10-hexahydro- 5-21-08-00522 (Beilstein Handbook Reference) BRN 1529222 5,6,7,8,9,10-Hexahydro-11H-cyclohepta(b)quinolin-11-one 7,8,9,10-Tetrahydro-6H-cyclohepta(b)quinolin-11-one），其CAS登记号是 5220-39-3，分子量为 213.28 g/mol。 依据分子式为 C14H15NO 的结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 213.28 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 推荐用于
应用场景：针对化学分析用途，（5220-39-3 11H-Cyclohepta(b)quinolin-11-one, 5,6,7,8,9,10-hexahydro- 5-21-08-00522 (Beilstein Handbook Reference) BRN 1529222 5,6,7,8,9,10-Hexahydro-11H-cyclohepta(b)quinolin-11-one 7,8,9,10-Tetrahydro-6H-cyclohepta(b)quinolin-11-one）是具有明确定量溯源的认证级对照品。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/
理化性质 Physical & Chemical Properties
| 中文名称 | |
| 分子式 | C14H15NO |
| 分子量 | 213.28 g/mol |
| 外观形态 | 淡黄色至黄色低熔点固体 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 8.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1958年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人徐明华，韩伟，杨光. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 115672135 A, 授权公告日 2017-10-11.
- Martínez F, Nielsen H, Mueller T C. "Method for the Synthesis of 5220-39-3 11H-Cyclohepta(b)quinolin-11-one, 5,6,7,8,9,10-hexahydro- 5-21-08-00522 (Beilstein Handbook Reference) BRN 1529222 5,6,7,8,9,10-Hexahydro-11H-cyclohepta(b)quinolin-11-one 7,8,9,10-Tetrahydro-6H-cyclohepta(b)quinolin-11-one" [P]. European Patent, EP 3339990 A1, 2023-02-12.
- 发明人赵玉洁，高志强，韩伟. "A Process for Preparing High-Purity 5220-39-3 11H-Cyclohepta(b)quinolin-11-one, 5,6,7,8,9,10-hexahydro- 5-21-08-00522 (Beilstein Handbook Reference) BRN 1529222 5,6,7,8,9,10-Hexahydro-11H-cyclohepta(b)quinolin-11-one 7,8,9,10-Tetrahydro-6H-cyclohepta(b)quinolin-11-one" [P]. 中国发明专利, 专利号 CN 108626358 A, 授权公告日 2023-10-25.
参考文献 Literature
- O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Molecules, 2022, 2310, (9), 1031-1042.
- Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Sep. Sci., 2022, 979, (3), 2294-2301.
- Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 5220-39-3 11H-Cyclohepta(b)quinolin-11-one, 5,6,7,8,9,10-hexahydro- 5-21-08-00522 (Beilstein Handbook Reference) BRN 1529222 5,6,7,8,9,10-Hexahydro-11H-cyclohepta(b)quinolin-11-one 7,8,9,10-Tetrahydro-6H-cyclohepta(b)quinolin-11-one Using HRMS and NMR". Phytochemistry, 2021, 1623, 6107-6136.
- Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2025, 1087, 9412-9418.
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