5-乙基-5-甲基乙内酰脲 CAS 5394-36-5

5394-36-5 9434G2C47P 5-Ethyl-5-methylhydantoin 5-Ethyl-5-methylimidazolidine-2,4-dione Hydantoin, 5-ethyl-5-methyl- 2,4-Imidazolidinedione, 5-ethyl-5-methyl- T11 5-24-05-00393 (Beilstein Handbook Reference) BRN 0081952 EINECS 226-402-8 Methylethylhydantoin 5-Methyl-5-ethylhydantoin NSC 1020 UNII-9434G2C47P

纯度 97%+现货药物标准品
CAS 号5394-36-5
分子式C6H10N2O2
分子量142.16 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-乙基-5-甲基乙内酰脲 5394-36-5 9434G2C47P 5-Ethyl-5-methylhydantoin 5-Ethyl-5-methylimidazolidine-2,4-dione Hydantoin, 5-ethyl-5-methyl- 2,4-Imidazolidinedione, 5-ethyl-5-methyl- T11 5-24-05-00393 (Beilstein Handbook Reference) BRN 0081952 EINECS 226-402-8 Methylethylhydantoin 5-Methyl-5-ethylhydantoin NSC 1020 UNII-9434G2C47P CAS 5394-36-5 结构式 Chemical Structure

产品介绍 Description

CAS 5394-36-5 对应的5-乙基-5-甲基乙内酰脲（5394-36-5 9434G2C47P 5-Ethyl-5-methylhydantoin 5-Ethyl-5-methylimidazolidine-2,4-dione Hydantoin, 5-ethyl-5-methyl- 2,4-Imidazolidinedione, 5-ethyl-5-methyl- T11 5-24-05-00393 (Beilstein Handbook Reference) BRN 0081952 EINECS 226-402-8 Methylethylhydantoin 5-Methyl-5-ethylhydantoin NSC 1020 UNII-9434G2C47P）为 CATO 佳途药物标准品产品线成员。分子式 C6H10N2O2，分子量 142.16。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括5-乙基-5-甲基乙内酰脲在内的目标物的控制。 化学式为 C6H10N2O2 的5-乙基-5-甲基乙内酰脲（5394-36-5 9434G2C47P 5-Ethyl-5-methylhydantoin 5-Ethyl-5-methylimidazolidine-2,4-dione Hydantoin, 5-ethyl-5-methyl- 2,4-Imidazolidinedione, 5-ethyl-5-methyl- T11 5-24-05-00393 (Beilstein Handbook Reference) BRN 0081952 EINECS 226-402-8 Methylethylhydantoin 5-Methyl-5-ethylhydantoin NSC 1020 UNII-9434G2C47P），其CAS登记号是 5394-36-5，分子量为 142.16 g/mol。 5-乙基-5-甲基乙内酰脲（分子式 C6H10N2O2）的化学结构中包含氨基酸衍生物，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留

应用场景：5-乙基-5-甲基乙内酰脲（5394-36-5 9434G2C47P 5-Ethyl-5-methylhydantoin 5-Ethyl-5-methylimidazolidine-2,4-dione Hydantoin, 5-ethyl-5-methyl- 2,4-Imidazolidinedione, 5-ethyl-5-methyl- T11 5-24-05-00393 (Beilstein Handbook Reference) BRN 0081952 EINECS 226-402-8 Methylethylhydantoin 5-Methyl-5-ethylhydantoin NSC

理化性质 Physical & Chemical Properties

中文名称5-乙基-5-甲基乙内酰脲
分子式C6H10N2O2
分子量142.16 g/mol
外观形态白色至淡黄色液体。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1958年
含氮原子数2

相关专利 Related Patents

  1. 发明人郭海燕，张德明，杨光. "一种5-乙基-5-甲基乙内酰脲的合成方法" [P]. 中国发明专利, 专利号 CN 113839101 B, 授权公告日 2024-03-05.
  2. 发明人李文辉，王建平，马晓峰. "Method for the Synthesis of 5394-36-5 9434G2C47P 5-Ethyl-5-methylhydantoin 5-Ethyl-5-methylimidazolidine-2,4-dione Hydantoin, 5-ethyl-5-methyl- 2,4-Imidazolidinedione, 5-ethyl-5-methyl- T11 5-24-05-00393 (Beilstein Handbook Reference) BRN 0081952 EINECS 226-402-8 Methylethylhydantoin 5-Methyl-5-ethylhydantoin NSC 1020 UNII-9434G2C47P" [P]. 中国发明专利, 专利号 CN 108404400 A, 授权公告日 2018-01-11.
  3. 发明人李文辉，陈志强，郑宇鹏. "A Process for Preparing High-Purity 5394-36-5 9434G2C47P 5-Ethyl-5-methylhydantoin 5-Ethyl-5-methylimidazolidine-2,4-dione Hydantoin, 5-ethyl-5-methyl- 2,4-Imidazolidinedione, 5-ethyl-5-methyl- T11 5-24-05-00393 (Beilstein Handbook Reference) BRN 0081952 EINECS 226-402-8 Methylethylhydantoin 5-Methyl-5-ethylhydantoin NSC 1020 UNII-9434G2C47P" [P]. 中国发明专利, 专利号 CN 116383468 A, 授权公告日 2023-11-26.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 5-乙基-5-甲基乙内酰脲 in Pharmaceutical Formulations". Chemosphere, 2012, 2263, (7), 1622-1631.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-乙基-5-甲基乙内酰脲 as an Impurity". Food Chem., 2022, 1196, 2592-2598.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 5394-36-5 9434G2C47P 5-Ethyl-5-methylhydantoin 5-Ethyl-5-methylimidazolidine-2,4-dione Hydantoin, 5-ethyl-5-methyl- 2,4-Imidazolidinedione, 5-ethyl-5-methyl- T11 5-24-05-00393 (Beilstein Handbook Reference) BRN 0081952 EINECS 226-402-8 Methylethylhydantoin 5-Methyl-5-ethylhydantoin NSC 1020 UNII-9434G2C47P Using HRMS and NMR". Phytochemistry, 2023, 605, 1518-1548.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate 5-乙基-5-甲基乙内酰脲 Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2023, 1238, (3), 4111-4131.

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