(1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇 CAS 60410-16-4

(1R,4S)-4-Hydroxycyclopent-2-en-1-yl acetate (+)-(1R-cis)-4-Cyclopentene-1,3-diol monoacetate (1R,3S)-(+)-1-Acetoxy-3-hydroxy-4-cyclopentene (1R,3S)-(+)-4-Cyclopentene-1,3-diol 1-acetate (1R,4S)-4-Hydroxycyclopent-2-enyl acetate (1S,4R)-4-Acetoxy-2-cyclopenten-1-ol Acetic acid (1R,4S)-4-hydroxycyclopent-2-enyl ester (1s,4r)-cis-4-Acetoxy-2-cyclopenten-1-ol 60410-16-4

纯度 97%+现货药物标准品
CAS 号60410-16-4
分子式C7H10O3
分子量142.15 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇 (1R,4S)-4-Hydroxycyclopent-2-en-1-yl acetate (+)-(1R-cis)-4-Cyclopentene-1,3-diol monoacetate (1R,3S)-(+)-1-Acetoxy-3-hydroxy-4-cyclopentene (1R,3S)-(+)-4-Cyclopentene-1,3-diol 1-acetate (1R,4S)-4-Hydroxycyclopent-2-enyl acetate (1S,4R)-4-Acetoxy-2-cyclopenten-1-ol Acetic acid (1R,4S)-4-hydroxycyclopent-2-enyl ester (1s,4r)-cis-4-Acetoxy-2-cyclopenten-1-ol 60410-16-4 CAS 60410-16-4 结构式 Chemical Structure

产品介绍 Description

CAS 60410-16-4 对应的(1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇（(1R,4S)-4-Hydroxycyclopent-2-en-1-yl acetate (+)-(1R-cis)-4-Cyclopentene-1,3-diol monoacetate (1R,3S)-(+)-1-Acetoxy-3-hydroxy-4-cyclopentene (1R,3S)-(+)-4-Cyclopentene-1,3-diol 1-acetate (1R,4S)-4-Hydroxycyclopent-2-enyl acetate (1S,4R)-4-Acetoxy-2-cyclopenten-1-ol Acetic acid (1R,4S)-4-hydroxycyclopent-2-enyl ester (1s,4r)-cis-4-Acetoxy-2-cyclopenten-1-ol 60410-16-4）为 CATO 佳途药物标准品产品线成员。分子式 C7H10O3，分子量 142.15。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 (1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇（(1R,4S)-4-Hydroxycyclopent-2-en-1-yl acetate (+)-(1R-cis)-4-Cyclopentene-1,3-diol monoacetate (1R,3S)-(+)-1-Acetoxy-3-hydroxy-4-cyclopentene (1R,3S)-(+)-4-Cyclopentene-1,3-diol 1-acetate (1R,4S)-4-Hydroxycyclopent-2-enyl acetate (1S,4R)-4-Acetoxy-2-cyclopenten-1-ol Acetic acid (1R,4S)-4-hydroxyc

应用场景：在化学分析实验室中，(1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇（CAS 60410-16-4）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制

理化性质 Physical & Chemical Properties

中文名称(1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇
分子式C7H10O3
分子量142.15 g/mol
外观形态白色至类白色液体
纯度97%+
储存条件2-8°C冷藏保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1974年

相关专利 Related Patents

  1. 发明人高志强，何建平，张德明. "一种(1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇的合成方法" [P]. 中国发明专利, 专利号 CN 113941744 B, 授权公告日 2020-12-23.
  2. 发明人钱学锋，杨光，高志强. "Method for the Synthesis of (1R,4S)-4-Hydroxycyclopent-2-en-1-yl acetate (+)-(1R-cis)-4-Cyclopentene-1,3-diol monoacetate (1R,3S)-(+)-1-Acetoxy-3-hydroxy-4-cyclopentene (1R,3S)-(+)-4-Cyclopentene-1,3-diol 1-acetate (1R,4S)-4-Hydroxycyclopent-2-enyl acetate (1S,4R)-4-Acetoxy-2-cyclopenten-1-ol Acetic acid (1R,4S)-4-hydroxycyclopent-2-enyl ester (1s,4r)-cis-4-Acetoxy-2-cyclopenten-1-ol 60410-16-4" [P]. 中国发明专利, 专利号 CN 111692542 A, 授权公告日 2023-03-28.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of (1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇 in Pharmaceutical Formulations". Sci. Total Environ., 2022, 1813, 9596-9606.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1<I>S</I>,4<I>R</I>)-顺式-4-乙酰氧基-2-环戊烯-1-醇 as an Impurity". Talanta, 2011, 587, 3348-3354.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of (1R,4S)-4-Hydroxycyclopent-2-en-1-yl acetate (+)-(1R-cis)-4-Cyclopentene-1,3-diol monoacetate (1R,3S)-(+)-1-Acetoxy-3-hydroxy-4-cyclopentene (1R,3S)-(+)-4-Cyclopentene-1,3-diol 1-acetate (1R,4S)-4-Hydroxycyclopent-2-enyl acetate (1S,4R)-4-Acetoxy-2-cyclopenten-1-ol Acetic acid (1R,4S)-4-hydroxycyclopent-2-enyl ester (1s,4r)-cis-4-Acetoxy-2-cyclopenten-1-ol 60410-16-4 Using HRMS and NMR". Chromatographia, 2012, 969, 5128-5141.

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