2-硝基苄氯 CAS 612-23-7

612-23-7 HB8U484NPM o-Nitrobenzyl chloride Benzene, 1-(chloromethyl)-2-nitro- (9CI) alpha-Chloro-2-nitrotoluene Toluene, alpha-chloro-o-nitro- Benzene, 1-(chloromethyl)-2-nitro- 4-05-00-00854 (Beilstein Handbook Reference) BRN 0388396 CCRIS 2323 1-(Chloromethyl)-2-nitrobenzene alpha-Chloro-o-nitrotoluene EINECS 210-300-5 2-Nitrobenzyl chloride NSC 66500 UNII-HB8U484NPM

纯度 97%+现货药物标准品
CAS 号612-23-7
分子式C7H12ClNO2
分子量177.63 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-硝基苄氯 612-23-7 HB8U484NPM o-Nitrobenzyl chloride Benzene, 1-(chloromethyl)-2-nitro- (9CI) alpha-Chloro-2-nitrotoluene Toluene, alpha-chloro-o-nitro- Benzene, 1-(chloromethyl)-2-nitro- 4-05-00-00854 (Beilstein Handbook Reference) BRN 0388396 CCRIS 2323 1-(Chloromethyl)-2-nitrobenzene alpha-Chloro-o-nitrotoluene EINECS 210-300-5 2-Nitrobenzyl chloride NSC 66500 UNII-HB8U484NPM CAS 612-23-7 结构式 Chemical Structure

产品介绍 Description

2-硝基苄氯（612-23-7 HB8U484NPM o-Nitrobenzyl chloride Benzene, 1-(chloromethyl)-2-nitro- (9CI) alpha-Chloro-2-nitrotoluene Toluene, alpha-chloro-o-nitro- Benzene, 1-(chloromethyl)-2-nitro- 4-05-00-00854 (Beilstein Handbook Reference) BRN 0388396 CCRIS 2323 1-(Chloromethyl)-2-nitrobenzene alpha-Chloro-o-nitrotoluene EINECS 210-300-5 2-Nitrobenzyl chloride NSC 66500 UNII-HB8U484NPM，CAS 号 612-23-7）是 CATO 佳途自主生产的药物标准品，分子式 C7H12ClNO2，分子量 177.63。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-硝基苄氯在内的目标物的控制。 CAS编号 612-23-7 对应的化合物2-硝基苄氯（英文标识 612-23-7 HB8U484NPM o-Nitrobenzyl chloride Benzene, 1-(chloromethyl)-2-nitro- (9CI) alpha-Chloro-2-nitrotoluene Toluene, alpha-chloro-o-nitro- Benzene, 1-(chloromethyl)-2-nitro- 4-05-00-00854 (Beilstein Handbook Reference) BRN 0388396 CCRIS 2323 1-(Chloromethyl)-2-nitrobenzene alpha-Chloro-o-nitrotoluene EINECS 210-300-5 2-Nitrobenzyl chloride NSC 66500 UNII-HB8U484NPM），化学式 C7H12ClNO2，相对分子质量 177.63。 从化学结构特征来看，2-硝基苄

应用场景：2-硝基苄氯（612-23-7 HB8U484NPM o-Nitrobenzyl chloride Benzene, 1-(chloromethyl)-2-nitro- (9CI) alpha-Chloro-2-nitrotoluene Toluene, alpha-chloro-o-nitro- Benzene, 1-(chloromethyl)-2-nitro- 4-05-00-00854 (Beilstein Handbook Reference) BRN 0388396 CCRIS 2323 1-(Chloromethyl)-2-nitrobenzene alpha-Chloro-o-

理化性质 Physical & Chemical Properties

中文名称2-硝基苄氯
分子式C7H12ClNO2
分子量177.63 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1957年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人王建平，陈志强，高志强. "一种2-硝基苄氯的合成方法" [P]. 中国发明专利, 专利号 CN 112318443 B, 授权公告日 2017-10-21.
  2. Jørgensen K, Sørensen M, Björnsson E. "Method for the Synthesis of 612-23-7 HB8U484NPM o-Nitrobenzyl chloride Benzene, 1-(chloromethyl)-2-nitro- (9CI) alpha-Chloro-2-nitrotoluene Toluene, alpha-chloro-o-nitro- Benzene, 1-(chloromethyl)-2-nitro- 4-05-00-00854 (Beilstein Handbook Reference) BRN 0388396 CCRIS 2323 1-(Chloromethyl)-2-nitrobenzene alpha-Chloro-o-nitrotoluene EINECS 210-300-5 2-Nitrobenzyl chloride NSC 66500 UNII-HB8U484NPM" [P]. European Patent, EP 3538405 A1, 2023-09-04.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 2-硝基苄氯 in Pharmaceutical Formulations". Chromatographia, 2016, 2450, 6375-6386.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-硝基苄氯 as an Impurity". Anal. Methods, 2023, 1239, 5473-5488.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 612-23-7 HB8U484NPM o-Nitrobenzyl chloride Benzene, 1-(chloromethyl)-2-nitro- (9CI) alpha-Chloro-2-nitrotoluene Toluene, alpha-chloro-o-nitro- Benzene, 1-(chloromethyl)-2-nitro- 4-05-00-00854 (Beilstein Handbook Reference) BRN 0388396 CCRIS 2323 1-(Chloromethyl)-2-nitrobenzene alpha-Chloro-o-nitrotoluene EINECS 210-300-5 2-Nitrobenzyl chloride NSC 66500 UNII-HB8U484NPM Using HRMS and NMR". Biomed. Chromatogr., 2021, 1045, (7), 2849-2872.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 2-硝基苄氯 Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2020, 1251, (11), 973-992.

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