3-氯苯基硼酸 CAS 63503-60-6

3-Chlorobenzeneboronic acid 3-chlorophenylboronic acid 3-chloro-phenyl-boronic acid 3-chlorophenyl boronic acid (3-chlorophenyl)boranediol (3-chlorophenyl)boronic acid 3-chlorophenylbornic acid m-Chlorophenylboronic acid 63503-60-6

纯度 97%+现货药物标准品
CAS 号63503-60-6
分子式C6H12BClO2
分子量162.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-氯苯基硼酸 3-Chlorobenzeneboronic acid 3-chlorophenylboronic acid 3-chloro-phenyl-boronic acid 3-chlorophenyl boronic acid (3-chlorophenyl)boranediol (3-chlorophenyl)boronic acid 3-chlorophenylbornic acid m-Chlorophenylboronic acid 63503-60-6 CAS 63503-60-6 结构式 Chemical Structure

产品介绍 Description

CAS 63503-60-6 对应的3-氯苯基硼酸（3-Chlorobenzeneboronic acid 3-chlorophenylboronic acid 3-chloro-phenyl-boronic acid 3-chlorophenyl boronic acid (3-chlorophenyl)boranediol (3-chlorophenyl)boronic acid 3-chlorophenylbornic acid m-Chlorophenylboronic acid 63503-60-6）为 CATO 佳途药物标准品产品线成员。分子式 C6H12BClO2，分子量 162.42。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

从化学结构特征来看，3-氯苯基硼酸的分子骨架中包含羧酸类，含羟基，含醚键，含氯取代。该化合物的不饱和度为0.5，表明结构中存在约0个环或双键等价单元。分子量为162.42 g/mol，属于中等分子量化合物。卤素原子的引入增加了化合物的电负性，在ECD（电子捕获检测器）中具有优良的响应灵敏度。 3-氯苯基硼酸（3-Chlorobenzeneboronic acid 3-chlorophenylboronic acid 3-chloro-phenyl-boronic acid 3-chlorophenyl boronic acid (3-chlorophenyl)boranediol (3-chlorophenyl)boronic acid 3-chlorophenylbornic acid m-Chlorophenylboronic acid 63503-60-6），CAS注册编号 63503-60-6，化学分子式为 C6H12BClO2，分子量 162.42 g/mol。 在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, M

应用场景：针对化学分析用途，3-氯苯基硼酸（3-Chlorobenzeneboronic acid 3-chlorophenylboronic acid 3-chloro-phenyl-boronic acid 3-chlorophenyl boronic acid (3-chlorophenyl)boranediol (3-chlorophenyl)boronic acid 3-chlorophenylbornic acid m-Chlorophenylboronic acid 63503-60-6）是具有明确定量溯源的认证级对照品。 推荐以3-氯苯基硼酸配制标准系列工作溶液，用于建立标准曲线实现外

理化性质 Physical & Chemical Properties

中文名称3-氯苯基硼酸
分子式C6H12BClO2
分子量162.42 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.5
CAS登记年份（估）1975年
卤素含量Cl取代

相关专利 Related Patents

  1. 发明人唐晓军，张德明，胡光. "一种3-氯苯基硼酸的合成方法" [P]. 中国发明专利, 专利号 CN 110354947 B, 授权公告日 2018-12-13.
  2. 发明人何建平，陈志强，唐晓军. "Method for the Synthesis of 3-Chlorobenzeneboronic acid 3-chlorophenylboronic acid 3-chloro-phenyl-boronic acid 3-chlorophenyl boronic acid (3-chlorophenyl)boranediol (3-chlorophenyl)boronic acid 3-chlorophenylbornic acid m-Chlorophenylboronic acid 63503-60-6" [P]. 中国发明专利, 专利号 CN 114709682 A, 授权公告日 2019-07-17.
  3. Hughes D C, Fischer A B, Kumar R. "A Process for Preparing High-Purity 3-Chlorobenzeneboronic acid 3-chlorophenylboronic acid 3-chloro-phenyl-boronic acid 3-chlorophenyl boronic acid (3-chlorophenyl)boranediol (3-chlorophenyl)boronic acid 3-chlorophenylbornic acid m-Chlorophenylboronic acid 63503-60-6" [P]. US Patent, US 10994762 B2, 2024-07-23.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 3-氯苯基硼酸 in Pharmaceutical Formulations". Anal. Chem., 2022, 896, 6268-6272.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-氯苯基硼酸 as an Impurity". Talanta, 2012, 545, (5), 6788-6807.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 3-Chlorobenzeneboronic acid 3-chlorophenylboronic acid 3-chloro-phenyl-boronic acid 3-chlorophenyl boronic acid (3-chlorophenyl)boranediol (3-chlorophenyl)boronic acid 3-chlorophenylbornic acid m-Chlorophenylboronic acid 63503-60-6 Using HRMS and NMR". J. Agric. Food Chem., 2012, 2228, 2391-2394.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 3-氯苯基硼酸 Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2023, 1281, (8), 3515-3521.

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