N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺 CAS 65181-78-4
65181-78-4 (1,1'-Biphenyl)-4,4'-diamine, N4,N4'-bis(3-methylphenyl)-N4,N4'-diphenyl- (1,1'-Biphenyl)-4,4'-diamine, N,N'-bis(3-methylphenyl)-N,N'-diphenyl- N,N'-Diphenyl-N,N'-bis(3-methylphenyl)-(1,1'-diphenyl)-4,4'-diamine N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine EC 413-810-8
| CAS 号 | 65181-78-4 |
| 分子式 | C38H68N2 |
| 分子量 | 552.96 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺（英文名 65181-78-4 (1,1'-Biphenyl)-4,4'-diamine, N4,N4'-bis(3-methylphenyl)-N4,N4'-diphenyl- (1,1'-Biphenyl)-4,4'-diamine, N,N'-bis(3-methylphenyl)-N,N'-diphenyl- N,N'-Diphenyl-N,N'-bis(3-methylphenyl)-(1,1'-diphenyl)-4,4'-diamine N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine EC 413-810-8，CAS 65181-78-4）属于药物标准品。分子式 C38H68N2，分子量 552.96。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
CAS编号 65181-78-4 对应的化合物N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺（英文标识 65181-78-4 (1,1'-Biphenyl)-4,4'-diamine, N4,N4'-bis(3-methylphenyl)-N4,N4'-diphenyl- (1,1'-Biphenyl)-4,4'-diamine, N,N'-bis(3-methylphenyl)-N,N'-diphenyl- N,N'-Diphenyl-N,N'-bis(3-methylphenyl)-(1,1'-diphenyl)-4,4'-diamine N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine EC 413-810-8），化学式 C38H68N2，相对分子质量 552.96。 N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺（C38H68N2）含有含氮杂环结构，含氰基。较高的碳氢比使其脂溶性较好，这些物理化学性质直接决定了其标准溶液的最佳配
应用场景：在化学分析实验室中，N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺（CAS 65181-78-4）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于室温保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放；
理化性质 Physical & Chemical Properties
| 中文名称 | N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺 |
| 分子式 | C38H68N2 |
| 分子量 | 552.96 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，避光 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 6.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1975年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人李文辉，林芳，朱建伟. "一种N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺的合成方法" [P]. 中国发明专利, 专利号 CN 110138034 A, 授权公告日 2017-02-13.
- 发明人钱学锋，黄志刚，何建平. "Method for the Synthesis of 65181-78-4 (1,1'-Biphenyl)-4,4'-diamine, N4,N4'-bis(3-methylphenyl)-N4,N4'-diphenyl- (1,1'-Biphenyl)-4,4'-diamine, N,N'-bis(3-methylphenyl)-N,N'-diphenyl- N,N'-Diphenyl-N,N'-bis(3-methylphenyl)-(1,1'-diphenyl)-4,4'-diamine N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine EC 413-810-8" [P]. 中国发明专利, 专利号 CN 116188091 B, 授权公告日 2016-08-10.
- 发明人杨光，朱建伟，林芳. "A Process for Preparing High-Purity 65181-78-4 (1,1'-Biphenyl)-4,4'-diamine, N4,N4'-bis(3-methylphenyl)-N4,N4'-diphenyl- (1,1'-Biphenyl)-4,4'-diamine, N,N'-bis(3-methylphenyl)-N,N'-diphenyl- N,N'-Diphenyl-N,N'-bis(3-methylphenyl)-(1,1'-diphenyl)-4,4'-diamine N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine EC 413-810-8" [P]. 中国发明专利, 专利号 CN 108882370 B, 授权公告日 2016-06-15.
参考文献 Literature
- Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺 in Pharmaceutical Formulations". J. Agric. Food Chem., 2022, 1954, (3), 5361-5364.
- Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺 as an Impurity". Food Chem., 2015, 1336, (2), 4662-4689.
- Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 65181-78-4 (1,1'-Biphenyl)-4,4'-diamine, N4,N4'-bis(3-methylphenyl)-N4,N4'-diphenyl- (1,1'-Biphenyl)-4,4'-diamine, N,N'-bis(3-methylphenyl)-N,N'-diphenyl- N,N'-Diphenyl-N,N'-bis(3-methylphenyl)-(1,1'-diphenyl)-4,4'-diamine N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine EC 413-810-8 Using HRMS and NMR". Talanta, 2024, 1269, 7292-7319.
- Brown R C, Davis S M. "Forced Degradation Studies to Evaluate N,N′-双(3-甲基苯基)-N,N′-二苯基-1,1′-联苯-4,4′-二胺 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2023, 1839, (9), 3861-3866.
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