维甲酸对羟基苯胺 CAS 65646-68-6

4-HPR 65646-68-6 D08JAC Fenretinide Fenretinide (Ewing's sarcoma), Cancer Research UK Fenretinide (ILE formulation), Children's Hospital LA Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx Fenretinide (intravenous, cancer), SciTech Development Fenretinide (iv), Children's Hospital LA Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products Fenretinide (oral, AMD), Sytera Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University Fenretinide (soft gel capsule, AMD), ReVision Therapeutics Fenretinide (soft gel capsule, AMD), Sirion Fenretinide (topical, actinic keratosis and cancer), SciTech Development LXS/4-HPR N-(4-hydroxyphenyl)retinamide RT-101 ST-602 SYT-101

纯度 97%+现货药物标准品
CAS 号65646-68-6
分子式C26H39NO2
分子量397.59 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

维甲酸对羟基苯胺 4-HPR 65646-68-6 D08JAC Fenretinide Fenretinide (Ewing's sarcoma), Cancer Research UK Fenretinide (ILE formulation), Children's Hospital LA Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx Fenretinide (intravenous, cancer), SciTech Development Fenretinide (iv), Children's Hospital LA Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products Fenretinide (oral, AMD), Sytera Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University Fenretinide (soft gel capsule, AMD), ReVision Therapeutics Fenretinide (soft gel capsule, AMD), Sirion Fenretinide (topical, actinic keratosis and cancer), SciTech Development LXS/4-HPR N-(4-hydroxyphenyl)retinamide RT-101 ST-602 SYT-101 CAS 65646-68-6 结构式 Chemical Structure

产品介绍 Description

CAS 65646-68-6 对应的维甲酸对羟基苯胺（4-HPR 65646-68-6 D08JAC Fenretinide Fenretinide (Ewing's sarcoma), Cancer Research UK Fenretinide (ILE formulation), Children's Hospital LA Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx Fenretinide (intravenous, cancer), SciTech Development Fenretinide (iv), Children's Hospital LA Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products Fenretinide (oral, AMD), Sytera Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University Fenretinide (soft gel capsule, AMD), ReVision Therapeutics Fenretinide (soft gel capsule, AMD), Sirion Fenretinide (topical, actinic keratosis and cancer), SciTech Development LXS/4-HPR N-(4-hydroxyphenyl)retinamide RT-101 ST-602 SYT-101）为 CATO 佳途药物标准品产品线成员。分子式 C26H39NO2，分子量 397.59。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

作为认证标准物质（CRM），维甲酸对羟基苯胺满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 维甲酸对羟基苯胺（4-HPR 65646-68-6 D08JAC Fenretinide Fenretinide (Ewing's sarcoma), Cancer Research UK Fenretinide (ILE formulation), Children's Hospital LA Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx Fenretinide (intravenous, cancer), SciTech

应用场景：针对化学分析用途，维甲酸对羟基苯胺（4-HPR 65646-68-6 D08JAC Fenretinide Fenretinide (Ewing's sarcoma), Cancer Research UK Fenretinide (ILE formulation), Children's Hospital LA Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles Fenretinide (intravenous emulsion, lymphoma/solid tumors/ped

理化性质 Physical & Chemical Properties

中文名称维甲酸对羟基苯胺
分子式C26H39NO2
分子量397.59 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1975年
含氮原子数1

相关专利 Related Patents

  1. 发明人罗永刚，刘建华，郑宇鹏. "一种维甲酸对羟基苯胺的合成方法" [P]. 中国发明专利, 专利号 CN 113366701 B, 授权公告日 2021-12-14.
  2. 发明人马晓峰，罗永刚，何建平. "Method for the Synthesis of 4-HPR 65646-68-6 D08JAC Fenretinide Fenretinide (Ewing's sarcoma), Cancer Research UK Fenretinide (ILE formulation), Children's Hospital LA Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx Fenretinide (intravenous, cancer), SciTech Development Fenretinide (iv), Children's Hospital LA Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products Fenretinide (oral, AMD), Sytera Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University Fenretinide (soft gel capsule, AMD), ReVision Therapeutics Fenretinide (soft gel capsule, AMD), Sirion Fenretinide (topical, actinic keratosis and cancer), SciTech Development LXS/4-HPR N-(4-hydroxyphenyl)retinamide RT-101 ST-602 SYT-101" [P]. 中国发明专利, 专利号 CN 117461261 B, 授权公告日 2019-03-11.
  3. 发明人马晓峰，陈志强，沈红梅. "A Process for Preparing High-Purity 4-HPR 65646-68-6 D08JAC Fenretinide Fenretinide (Ewing's sarcoma), Cancer Research UK Fenretinide (ILE formulation), Children's Hospital LA Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx Fenretinide (intravenous, cancer), SciTech Development Fenretinide (iv), Children's Hospital LA Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products Fenretinide (oral, AMD), Sytera Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University Fenretinide (soft gel capsule, AMD), ReVision Therapeutics Fenretinide (soft gel capsule, AMD), Sirion Fenretinide (topical, actinic keratosis and cancer), SciTech Development LXS/4-HPR N-(4-hydroxyphenyl)retinamide RT-101 ST-602 SYT-101" [P]. 中国发明专利, 专利号 CN 113705455 A, 授权公告日 2021-03-09.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 维甲酸对羟基苯胺 in Pharmaceutical Formulations". Biomed. Chromatogr., 2014, 694, (11), 1887-1897.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 维甲酸对羟基苯胺 as an Impurity". Rapid Commun. Mass Spectrom., 2022, 882, 4535-4542.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 4-HPR 65646-68-6 D08JAC Fenretinide Fenretinide (Ewing's sarcoma), Cancer Research UK Fenretinide (ILE formulation), Children's Hospital LA Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx Fenretinide (intravenous, cancer), SciTech Development Fenretinide (iv), Children's Hospital LA Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products Fenretinide (oral, AMD), Sytera Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University Fenretinide (soft gel capsule, AMD), ReVision Therapeutics Fenretinide (soft gel capsule, AMD), Sirion Fenretinide (topical, actinic keratosis and cancer), SciTech Development LXS/4-HPR N-(4-hydroxyphenyl)retinamide RT-101 ST-602 SYT-101 Using HRMS and NMR". Anal. Methods, 2016, 1278, (1), 18-42.

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