CAS 67110-79-6

67110-79-6 HWR60H5GZB Luprostiol [INN:BAN] (+-)-(Z)-7-((1R*,2S*,3S*,5R*)-2-(((2R*)-3-(m-Chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-((1R,2S,3S,5R)-2-(((2R)-3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 5-Heptenoic acid, 7-(2-((3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (1alpha(Z),2beta(R*),3alpha,5alpha)-(+-)- Luprostiol Luprostiolum [INN-Latin] Equestrolin EMD 34946 Reprodin Luprostiolum Prosolvin UNII-HWR60H5GZB

纯度 97%+现货药物标准品
CAS 号67110-79-6
分子式C21H29ClO6S
分子量444.97 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

67110-79-6 HWR60H5GZB Luprostiol [INN:BAN] (+-)-(Z)-7-((1R*,2S*,3S*,5R*)-2-(((2R*)-3-(m-Chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-((1R,2S,3S,5R)-2-(((2R)-3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 5-Heptenoic acid, 7-(2-((3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (1alpha(Z),2beta(R*),3alpha,5alpha)-(+-)- Luprostiol Luprostiolum [INN-Latin] Equestrolin EMD 34946 Reprodin Luprostiolum Prosolvin UNII-HWR60H5GZB CAS 67110-79-6 结构式 Chemical Structure

产品介绍 Description

（67110-79-6 HWR60H5GZB Luprostiol [INN:BAN] (+-)-(Z)-7-((1R*,2S*,3S*,5R*)-2-(((2R*)-3-(m-Chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-((1R,2S,3S,5R)-2-(((2R)-3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 5-Heptenoic acid, 7-(2-((3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (1alpha(Z),2beta(R*),3alpha,5alpha)-(+-)- Luprostiol Luprostiolum [INN-Latin] Equestrolin EMD 34946 Reprodin Luprostiolum Prosolvin UNII-HWR60H5GZB，CAS 号 67110-79-6）是 CATO 佳途自主生产的药物标准品，分子式 C21H29ClO6S，分子量 444.97。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

化学式为 C21H29ClO6S 的（67110-79-6 HWR60H5GZB Luprostiol INN:BAN (+-)-(Z)-7-((1R,2S,3S,5R)-2-(((2R)-3-(m-Chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-((1R,2S,3S,5R)-2-(((2R)-3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 5-Heptenoic acid, 7-(2-((3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (1alpha(Z),2beta(R),3alpha,5alpha)-(+-)- Luprostiol Luprostiolum INN-Latin Equestrolin EMD

应用场景：（67110-79-6 HWR60H5GZB Luprostiol INN:BAN (+-)-(Z)-7-((1R ,2S ,3S ,5R )-2-(((2R )-3-(m-Chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-((1R,2S,3S,5R)-2-(((2R)-3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 5-Hepte

理化性质 Physical & Chemical Properties

中文名称
分子式C21H29ClO6S
分子量444.97 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1976年
卤素含量Cl取代
含硫原子数1

相关专利 Related Patents

  1. 发明人朱建伟，钱学锋，林芳. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111966661 A, 授权公告日 2018-09-12.
  2. 发明人朱建伟，冯建国，胡光. "Method for the Synthesis of 67110-79-6 HWR60H5GZB Luprostiol [INN:BAN] (+-)-(Z)-7-((1R*,2S*,3S*,5R*)-2-(((2R*)-3-(m-Chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-((1R,2S,3S,5R)-2-(((2R)-3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 5-Heptenoic acid, 7-(2-((3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (1alpha(Z),2beta(R*),3alpha,5alpha)-(+-)- Luprostiol Luprostiolum [INN-Latin] Equestrolin EMD 34946 Reprodin Luprostiolum Prosolvin UNII-HWR60H5GZB" [P]. 中国发明专利, 专利号 CN 112081421 A, 授权公告日 2020-10-26.
  3. 发明人马晓峰，何建平，郭海燕. "A Process for Preparing High-Purity 67110-79-6 HWR60H5GZB Luprostiol [INN:BAN] (+-)-(Z)-7-((1R*,2S*,3S*,5R*)-2-(((2R*)-3-(m-Chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-((1R,2S,3S,5R)-2-(((2R)-3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 5-Heptenoic acid, 7-(2-((3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (1alpha(Z),2beta(R*),3alpha,5alpha)-(+-)- Luprostiol Luprostiolum [INN-Latin] Equestrolin EMD 34946 Reprodin Luprostiolum Prosolvin UNII-HWR60H5GZB" [P]. 中国发明专利, 专利号 CN 111906952 B, 授权公告日 2023-01-20.

参考文献 Literature

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  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Molecules, 2021, 1844, (4), 2392-2403.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 67110-79-6 HWR60H5GZB Luprostiol [INN:BAN] (+-)-(Z)-7-((1R*,2S*,3S*,5R*)-2-(((2R*)-3-(m-Chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-5-heptenoic acid 5-Heptenoic acid, 7-((1R,2S,3S,5R)-2-(((2R)-3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 5-Heptenoic acid, 7-(2-((3-(3-chlorophenoxy)-2-hydroxypropyl)thio)-3,5-dihydroxycyclopentyl)-, (1alpha(Z),2beta(R*),3alpha,5alpha)-(+-)- Luprostiol Luprostiolum [INN-Latin] Equestrolin EMD 34946 Reprodin Luprostiolum Prosolvin UNII-HWR60H5GZB Using HRMS and NMR". J. Agric. Food Chem., 2021, 443, (11), 1422-1436.

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