<I>N</I>-Boc-1,4-丁二胺 CAS 68076-36-8

tert-butyl 4-aminobutylcarbamate 68076-36-8 1-BOC-AMINO-1,4-BUTANEDIAMINE;4-(BOC-AMINO)BUTYLAMINE;BOC-1,4-DIAMINOBUTANE;BUTTPARK 121\06-09;CARBAMIC ACID, N-(4-AMINOBUTYL)-, 1,1-DIMETHYLETHYL ESTER;MONO-4-N-BOC-1,4-DIAMINOBUTANE;N-(4-AMINOBUTYL)CARBAMIC ACID TERT-BUTYL ESTER;N-(TERT-BUTOXYCARBONYL)-1,4-DIAMINOBUTANE;N-BOC-1,4-BUTANDIAMINE;N-BOC-1,4-BUTANEDIAMINE;N-BOC-1,4-DIAMINOBUTANE;N-T-BOC-1,4-DIAMINOBUTANE;TERT-BUTYL 4-AMINOBUTYLCARBAMATE;TERT-BUTYL N-(4-AMINOBUTYL)CARBAMATE GC10192

纯度 97%+现货药物标准品
CAS 号68076-36-8
分子式C9H20N2O2
分子量188.27 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>N</I>-Boc-1,4-丁二胺 tert-butyl 4-aminobutylcarbamate 68076-36-8 1-BOC-AMINO-1,4-BUTANEDIAMINE;4-(BOC-AMINO)BUTYLAMINE;BOC-1,4-DIAMINOBUTANE;BUTTPARK 121\06-09;CARBAMIC ACID, N-(4-AMINOBUTYL)-, 1,1-DIMETHYLETHYL ESTER;MONO-4-N-BOC-1,4-DIAMINOBUTANE;N-(4-AMINOBUTYL)CARBAMIC ACID TERT-BUTYL ESTER;N-(TERT-BUTOXYCARBONYL)-1,4-DIAMINOBUTANE;N-BOC-1,4-BUTANDIAMINE;N-BOC-1,4-BUTANEDIAMINE;N-BOC-1,4-DIAMINOBUTANE;N-T-BOC-1,4-DIAMINOBUTANE;TERT-BUTYL 4-AMINOBUTYLCARBAMATE;TERT-BUTYL N-(4-AMINOBUTYL)CARBAMATE GC10192 CAS 68076-36-8 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的<I>N</I>-Boc-1,4-丁二胺（tert-butyl 4-aminobutylcarbamate 68076-36-8 1-BOC-AMINO-1,4-BUTANEDIAMINE;4-(BOC-AMINO)BUTYLAMINE;BOC-1,4-DIAMINOBUTANE;BUTTPARK 121\06-09;CARBAMIC ACID, N-(4-AMINOBUTYL)-, 1,1-DIMETHYLETHYL ESTER;MONO-4-N-BOC-1,4-DIAMINOBUTANE;N-(4-AMINOBUTYL)CARBAMIC ACID TERT-BUTYL ESTER;N-(TERT-BUTOXYCARBONYL)-1,4-DIAMINOBUTANE;N-BOC-1,4-BUTANDIAMINE;N-BOC-1,4-BUTANEDIAMINE;N-BOC-1,4-DIAMINOBUTANE;N-T-BOC-1,4-DIAMINOBUTANE;TERT-BUTYL 4-AMINOBUTYLCARBAMATE;TERT-BUTYL N-(4-AMINOBUTYL)CARBAMATE GC10192）为药物标准品，CAS 登记号 68076-36-8，分子式 C9H20N2O2，分子量 188.27。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

受分子结构中氨基酸衍生物，酰胺类，含羟基，含醚键的影响，<I>N</I>-Boc-1,4-丁二胺表现为白色至类白色结晶性粉末。（具有氨/胺类微弱气味）。其固体形态的物理化学属性——包括188.27 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 CAS编号 68076-36-8 对应的化合物<I>N</I>-Boc-1,4-丁二胺（英文标识 tert-butyl 4-aminobutylcarbamate 68076-36-8 1-BOC-AMINO-1,4-BUTANEDIAMINE;4-(BOC-AMINO)BUTYLAMINE;BOC-1,4-DIAMINOBUTANE;BUTTPARK 121\06-09;CARBAMIC ACID, N-(4-AMINOBUTYL)-, 1,1-DIMETHYLETHYL ESTER;MONO-4-N-BOC-1,4-DIAMINOBUTANE;N-(4-AMINOBUTYL)CARBAMIC ACID TERT-BUT

应用场景：在化学分析实验室中，<I>N</I>-Boc-1,4-丁二胺（CAS 68076-36-8）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以<I>N</I>-Boc-1,4-丁二胺配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后

理化性质 Physical & Chemical Properties

中文名称<I>N</I>-Boc-1,4-丁二胺
分子式C9H20N2O2
分子量188.27 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1976年
含氮原子数2

相关专利 Related Patents

  1. Anderson J P, Thompson G K, Hughes D C. "一种<I>N</I>-Boc-1,4-丁二胺的合成方法" [P]. US Patent, US 10415977 B2, 2015-04-14.
  2. 发明人朱建伟，孙丽萍，陈志强. "Method for the Synthesis of tert-butyl 4-aminobutylcarbamate 68076-36-8 1-BOC-AMINO-1,4-BUTANEDIAMINE;4-(BOC-AMINO)BUTYLAMINE;BOC-1,4-DIAMINOBUTANE;BUTTPARK 121\06-09;CARBAMIC ACID, N-(4-AMINOBUTYL)-, 1,1-DIMETHYLETHYL ESTER;MONO-4-N-BOC-1,4-DIAMINOBUTANE;N-(4-AMINOBUTYL)CARBAMIC ACID TERT-BUTYL ESTER;N-(TERT-BUTOXYCARBONYL)-1,4-DIAMINOBUTANE;N-BOC-1,4-BUTANDIAMINE;N-BOC-1,4-BUTANEDIAMINE;N-BOC-1,4-DIAMINOBUTANE;N-T-BOC-1,4-DIAMINOBUTANE;TERT-BUTYL 4-AMINOBUTYLCARBAMATE;TERT-BUTYL N-(4-AMINOBUTYL)CARBAMATE GC10192" [P]. 中国发明专利, 专利号 CN 117561806 B, 授权公告日 2018-03-28.
  3. Johnson M A, Lee S K, Patel M V. "A Process for Preparing High-Purity tert-butyl 4-aminobutylcarbamate 68076-36-8 1-BOC-AMINO-1,4-BUTANEDIAMINE;4-(BOC-AMINO)BUTYLAMINE;BOC-1,4-DIAMINOBUTANE;BUTTPARK 121\06-09;CARBAMIC ACID, N-(4-AMINOBUTYL)-, 1,1-DIMETHYLETHYL ESTER;MONO-4-N-BOC-1,4-DIAMINOBUTANE;N-(4-AMINOBUTYL)CARBAMIC ACID TERT-BUTYL ESTER;N-(TERT-BUTOXYCARBONYL)-1,4-DIAMINOBUTANE;N-BOC-1,4-BUTANDIAMINE;N-BOC-1,4-BUTANEDIAMINE;N-BOC-1,4-DIAMINOBUTANE;N-T-BOC-1,4-DIAMINOBUTANE;TERT-BUTYL 4-AMINOBUTYLCARBAMATE;TERT-BUTYL N-(4-AMINOBUTYL)CARBAMATE GC10192" [P]. US Patent, US 9798709 B2, 2023-01-21.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of <I>N</I>-Boc-1,4-丁二胺 in Pharmaceutical Formulations". J. Sep. Sci., 2011, 214, 1963-1974.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>N</I>-Boc-1,4-丁二胺 as an Impurity". Anal. Chim. Acta, 2016, 2309, 3176-3205.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of tert-butyl 4-aminobutylcarbamate 68076-36-8 1-BOC-AMINO-1,4-BUTANEDIAMINE;4-(BOC-AMINO)BUTYLAMINE;BOC-1,4-DIAMINOBUTANE;BUTTPARK 121\06-09;CARBAMIC ACID, N-(4-AMINOBUTYL)-, 1,1-DIMETHYLETHYL ESTER;MONO-4-N-BOC-1,4-DIAMINOBUTANE;N-(4-AMINOBUTYL)CARBAMIC ACID TERT-BUTYL ESTER;N-(TERT-BUTOXYCARBONYL)-1,4-DIAMINOBUTANE;N-BOC-1,4-BUTANDIAMINE;N-BOC-1,4-BUTANEDIAMINE;N-BOC-1,4-DIAMINOBUTANE;N-T-BOC-1,4-DIAMINOBUTANE;TERT-BUTYL 4-AMINOBUTYLCARBAMATE;TERT-BUTYL N-(4-AMINOBUTYL)CARBAMATE GC10192 Using HRMS and NMR". J. Pharm. Biomed. Anal., 2013, 1291, (8), 6633-6660.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate <I>N</I>-Boc-1,4-丁二胺 Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2018, 686, (7), 9363-9373.

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