4′-(三氟甲基)乙酰苯 CAS 709-63-7

4'-(Trifluoromethyl)acetophenone 4'-(trifluoromethyl) acetophenone 1-[4-(trifluoromethyl)phenyl]ethan-1-one 4-(trifluoromethyl)acetophenone 4-trifluoromethylacetophenone p-trifluoromethylacetophenone 4'-(trifluoromethyl)-acetophenone 1-[4-(trifluoromethyl)phenyl]ethanone 4'-trifluoromethylacetophenone 709-63-7

纯度 97%+现货药物标准品
CAS 号709-63-7
分子式C9H13F3O
分子量194.19 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4′-(三氟甲基)乙酰苯 4'-(Trifluoromethyl)acetophenone 4'-(trifluoromethyl) acetophenone 1-[4-(trifluoromethyl)phenyl]ethan-1-one 4-(trifluoromethyl)acetophenone 4-trifluoromethylacetophenone p-trifluoromethylacetophenone 4'-(trifluoromethyl)-acetophenone 1-[4-(trifluoromethyl)phenyl]ethanone 4'-trifluoromethylacetophenone 709-63-7 CAS 709-63-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品4′-(三氟甲基)乙酰苯（4'-(Trifluoromethyl)acetophenone 4'-(trifluoromethyl) acetophenone 1-[4-(trifluoromethyl)phenyl]ethan-1-one 4-(trifluoromethyl)acetophenone 4-trifluoromethylacetophenone p-trifluoromethylacetophenone 4'-(trifluoromethyl)-acetophenone 1-[4-(trifluoromethyl)phenyl]ethanone 4'-trifluoromethylacetophenone 709-63-7，CAS 709-63-7），分子式 C9H13F3O，分子量 194.19。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

CAS编号 709-63-7 对应的化合物4′-(三氟甲基)乙酰苯（英文标识 4'-(Trifluoromethyl)acetophenone 4'-(trifluoromethyl) acetophenone 1-4-(trifluoromethyl)phenylethan-1-one 4-(trifluoromethyl)acetophenone 4-trifluoromethylacetophenone p-trifluoromethylacetophenone 4'-(trifluoromethyl)-acetophenone 1-4-(trifluoromethyl)phenylethanone 4'-trifluoromethylacetophenone 709-63-7），化学式 C9H13F3O，相对分子质量 194.19。 从化学结构特征来看，4′-(三氟甲基)乙酰苯的分子骨架中包含含羟基，含醚键，含氟取代。该化合物的不饱和度为2.0，表明结构中存在约2个环或双键等价单元。分子量为194.19 g/mol，属于中等分子量化合物。因分子内存在卤素取代基（F/C

应用场景：4′-(三氟甲基)乙酰苯（4'-(Trifluoromethyl)acetophenone 4'-(trifluoromethyl) acetophenone 1- 4-(trifluoromethyl)phenyl ethan-1-one 4-(trifluoromethyl)acetophenone 4-trifluoromethylacetophenone p-trifluoromethylacetophenone 4'-(trifluoromethyl)-acetophenone 1- 4-(trifluoromethyl)phenyl ethanone 4'-trifluoromet

理化性质 Physical & Chemical Properties

中文名称4′-(三氟甲基)乙酰苯
分子式C9H13F3O
分子量194.19 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1957年
卤素含量F取代

相关专利 Related Patents

  1. Schröder R, Lee S K, Mueller T. "一种4′-(三氟甲基)乙酰苯的合成方法" [P]. US Patent, US 10169657 B2, 2018-04-24.
  2. 发明人张德明，郑宇鹏，冯建国. "Method for the Synthesis of 4'-(Trifluoromethyl)acetophenone 4'-(trifluoromethyl) acetophenone 1-[4-(trifluoromethyl)phenyl]ethan-1-one 4-(trifluoromethyl)acetophenone 4-trifluoromethylacetophenone p-trifluoromethylacetophenone 4'-(trifluoromethyl)-acetophenone 1-[4-(trifluoromethyl)phenyl]ethanone 4'-trifluoromethylacetophenone 709-63-7" [P]. 中国发明专利, 专利号 CN 113725964 A, 授权公告日 2023-07-07.
  3. Anderson J P, Hughes D C, Brown S R. "A Process for Preparing High-Purity 4'-(Trifluoromethyl)acetophenone 4'-(trifluoromethyl) acetophenone 1-[4-(trifluoromethyl)phenyl]ethan-1-one 4-(trifluoromethyl)acetophenone 4-trifluoromethylacetophenone p-trifluoromethylacetophenone 4'-(trifluoromethyl)-acetophenone 1-[4-(trifluoromethyl)phenyl]ethanone 4'-trifluoromethylacetophenone 709-63-7" [P]. US Patent, US 10551904 B2, 2016-06-18.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 4′-(三氟甲基)乙酰苯 in Pharmaceutical Formulations". J. Agric. Food Chem., 2020, 875, 2419-2435.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4′-(三氟甲基)乙酰苯 as an Impurity". Chromatographia, 2010, 1125, 9217-9234.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 4'-(Trifluoromethyl)acetophenone 4'-(trifluoromethyl) acetophenone 1-[4-(trifluoromethyl)phenyl]ethan-1-one 4-(trifluoromethyl)acetophenone 4-trifluoromethylacetophenone p-trifluoromethylacetophenone 4'-(trifluoromethyl)-acetophenone 1-[4-(trifluoromethyl)phenyl]ethanone 4'-trifluoromethylacetophenone 709-63-7 Using HRMS and NMR". Anal. Chim. Acta, 2011, 976, (11), 3470-3488.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate 4′-(三氟甲基)乙酰苯 Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2022, 2395, 799-825.

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