Boc-<SC>D</SC>-Phe(3-Cl)-OH CAS 80102-25-6

(2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propanoic acid (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propionic acid (2R)-3-(3-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2R)-3-(3-chlorophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-25-6 Boc-D-3-Chlorophe

纯度 97%+现货药物标准品
CAS 号80102-25-6
分子式C14H24ClNO4
分子量305.80 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Boc-<SC>D</SC>-Phe(3-Cl)-OH (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propanoic acid (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propionic acid (2R)-3-(3-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2R)-3-(3-chlorophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-25-6 Boc-D-3-Chlorophe CAS 80102-25-6 结构式 Chemical Structure

产品介绍 Description

CAS 80102-25-6 对应的Boc-<SC>D</SC>-Phe(3-Cl)-OH（(2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propanoic acid (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propionic acid (2R)-3-(3-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2R)-3-(3-chlorophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-25-6 Boc-D-3-Chlorophe）为 CATO 佳途药物标准品产品线成员。分子式 C14H24ClNO4，分子量 305.80。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

作为认证标准物质（CRM），Boc-<SC>D</SC>-Phe(3-Cl)-OH满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 Boc-<SC>D</SC>-Phe(3-Cl)-OH（(2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propanoic acid (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propionic acid (2R)-3-(3-chlorophenyl)-2-(2-methylpropan-2-yl)oxycarbonylaminopropanoic acid (2R)-3-(3-chlorophenyl)-2-(2-methylpropan-2-yl)oxy-oxomethylaminopropanoic acid 80102-25-6 Boc-D-3-Chlorophe），CAS注册编号

应用场景：Boc-<SC>D</SC>-Phe(3-Cl)-OH（(2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propanoic acid (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propionic acid (2R)-3-(3-chlorophenyl)-2- (2-methylpropan-2-yl)oxycarbonylamino propanoic acid (2R)-3-(3-chlorophenyl)-2- (2-methylpropan-2-yl)oxy-oxome

理化性质 Physical & Chemical Properties

中文名称Boc-<SC>D</SC>-Phe(3-Cl)-OH
分子式C14H24ClNO4
分子量305.80 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1979年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人杨光，罗永刚，胡光. "一种Boc-<SC>D</SC>-Phe(3-Cl)-OH的合成方法" [P]. 中国发明专利, 专利号 CN 116706651 A, 授权公告日 2022-04-03.
  2. Williams B T, Klinger H, Park J H. "Method for the Synthesis of (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propanoic acid (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propionic acid (2R)-3-(3-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2R)-3-(3-chlorophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-25-6 Boc-D-3-Chlorophe" [P]. US Patent, US 11429431 B2, 2019-02-28.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of Boc-<SC>D</SC>-Phe(3-Cl)-OH in Pharmaceutical Formulations". Talanta, 2018, 1087, 2252-2278.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of Boc-<SC>D</SC>-Phe(3-Cl)-OH as an Impurity". J. Chromatogr. A, 2018, 541, (12), 4246-4267.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propanoic acid (2R)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propionic acid (2R)-3-(3-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2R)-3-(3-chlorophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-25-6 Boc-D-3-Chlorophe Using HRMS and NMR". J. Nat. Prod., 2012, 2135, 2598-2606.

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