Boc-Phe(4-Me)-OH CAS 80102-26-7

(2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propionic acid (2S)-3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-(4-methylphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-26-7 Boc-L-4-Methylphe

纯度 97%+现货药物标准品
CAS 号80102-26-7
分子式C15H27NO4
分子量285.38 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Boc-Phe(4-Me)-OH (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propionic acid (2S)-3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-(4-methylphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-26-7 Boc-L-4-Methylphe CAS 80102-26-7 结构式 Chemical Structure

产品介绍 Description

CAS 80102-26-7 对应的Boc-Phe(4-Me)-OH（(2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propionic acid (2S)-3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-(4-methylphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-26-7 Boc-L-4-Methylphe）为 CATO 佳途药物标准品产品线成员。分子式 C15H27NO4，分子量 285.38。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C15H27NO4 的Boc-Phe(4-Me)-OH（(2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propionic acid (2S)-3-(4-methylphenyl)-2-(2-methylpropan-2-yl)oxycarbonylaminopropanoic acid (2S)-3-(4-methylphenyl)-2-(2-methylpropan-2-yl)oxy-oxomethylaminopropanoic acid 80102-26-7 Boc-L-4-Methylphe），其CAS登记号是 80102-26-7，分子量为 285.38 g/mol。 受分子结构中酰胺类，羧酸类，含羟基，含醚键的影响，Boc-Phe(

应用场景：针对化学分析用途，Boc-Phe(4-Me)-OH（(2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propionic acid (2S)-3-(4-methylphenyl)-2- (2-methylpropan-2-yl)oxycarbonylamino propanoic acid (2S)-3-(4-methylphenyl)-2- (2-methylpropan-2-yl)oxy-oxomethyl amino propa

理化性质 Physical & Chemical Properties

中文名称Boc-Phe(4-Me)-OH
分子式C15H27NO4
分子量285.38 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1979年
含氮原子数1

相关专利 Related Patents

  1. Johansson L, Rossi M, Schröder R. "一种Boc-Phe(4-Me)-OH的合成方法" [P]. European Patent, EP 3532162 A1, 2016-09-07.
  2. 发明人陈志强，沈红梅，高志强. "Method for the Synthesis of (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propionic acid (2S)-3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-(4-methylphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-26-7 Boc-L-4-Methylphe" [P]. 中国发明专利, 专利号 CN 112518923 B, 授权公告日 2018-09-23.
  3. 发明人郑宇鹏，罗永刚，马晓峰. "A Process for Preparing High-Purity (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propionic acid (2S)-3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-(4-methylphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-26-7 Boc-L-4-Methylphe" [P]. 中国发明专利, 专利号 CN 109335237 B, 授权公告日 2023-06-05.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of Boc-Phe(4-Me)-OH in Pharmaceutical Formulations". Sci. Total Environ., 2015, 2087, (10), 5603-5621.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of Boc-Phe(4-Me)-OH as an Impurity". Molecules, 2022, 214, 7922-7936.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propanoic acid (2S)-2-(tert-butoxycarbonylamino)-3-(p-tolyl)propionic acid (2S)-3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (2S)-3-(4-methylphenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid 80102-26-7 Boc-L-4-Methylphe Using HRMS and NMR". Phytochemistry, 2018, 1067, 99-108.

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