反式-2-苯基乙烯基硼酸频哪醇酯 CAS 83947-56-2
trans-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)styrene beta-styrylboronic acid pinacol ester trans-styrylboronic acid, pinacol ester trans-2-phenylvinylboronic acid pinacol ester trans-beta-styrylboronic acid pinacol ester (E)-Phenylethenylboronic acid, pinacol ester (E)-4,4,5,5-Tetramethyl-2-(2-phenylvinyl)-1,3,2-dioxaborolane 83947-56-2
| CAS 号 | 83947-56-2 |
| 分子式 | C14H25BO2 |
| 分子量 | 236.16 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 83947-56-2 对应的反式-2-苯基乙烯基硼酸频哪醇酯（trans-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)styrene beta-styrylboronic acid pinacol ester trans-styrylboronic acid, pinacol ester trans-2-phenylvinylboronic acid pinacol ester trans-beta-styrylboronic acid pinacol ester (E)-Phenylethenylboronic acid, pinacol ester (E)-4,4,5,5-Tetramethyl-2-(2-phenylvinyl)-1,3,2-dioxaborolane 83947-56-2）为 CATO 佳途药物标准品产品线成员。分子式 C14H25BO2，分子量 236.16。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 CAS编号 83947-56-2 对应的化合物反式-2-苯基乙烯基硼酸频哪醇酯（英文标识 trans-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)styrene beta-styrylboronic acid pinacol ester trans-styrylboronic acid, pinacol ester trans-2-phenylvinylboronic acid pinacol ester trans-beta-styrylboronic acid pinacol ester (E)-Phenylethenylboronic acid, pinacol ester (E)-4,4,5,5-Tetramethyl-2-(2-phenylvinyl)-1,3,2-dioxaborolane 83947-56-2），化学式 C14H25BO2，相对分子质量 236.16。 反式-2-苯基乙烯基硼酸
应用场景：从实际应用出发，反式-2-苯基乙烯基硼酸频哪醇酯（CAS 83947-56-2）在化学分析中作为关键的基准对照物质。 推荐以反式-2-苯基乙烯基硼酸频哪醇酯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于室温保存条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | 反式-2-苯基乙烯基硼酸频哪醇酯 |
| 分子式 | C14H25BO2 |
| 分子量 | 236.16 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 室温保存 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 在推荐条件下性质稳定 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.5 |
| CAS登记年份（估） | 1980年 |
相关专利 Related Patents
- 发明人马晓峰，罗永刚，郑宇鹏. "一种反式-2-苯基乙烯基硼酸频哪醇酯的合成方法" [P]. 中国发明专利, 专利号 CN 109060938 A, 授权公告日 2024-04-28.
- Mueller T C, Kowalski A, Martínez F. "Method for the Synthesis of trans-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)styrene beta-styrylboronic acid pinacol ester trans-styrylboronic acid, pinacol ester trans-2-phenylvinylboronic acid pinacol ester trans-beta-styrylboronic acid pinacol ester (E)-Phenylethenylboronic acid, pinacol ester (E)-4,4,5,5-Tetramethyl-2-(2-phenylvinyl)-1,3,2-dioxaborolane 83947-56-2" [P]. European Patent, EP 3013197 A1, 2021-04-05.
- Kowalski A, Björnsson E, Nielsen H. "A Process for Preparing High-Purity trans-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)styrene beta-styrylboronic acid pinacol ester trans-styrylboronic acid, pinacol ester trans-2-phenylvinylboronic acid pinacol ester trans-beta-styrylboronic acid pinacol ester (E)-Phenylethenylboronic acid, pinacol ester (E)-4,4,5,5-Tetramethyl-2-(2-phenylvinyl)-1,3,2-dioxaborolane 83947-56-2" [P]. European Patent, EP 3605231 A1, 2023-05-14.
参考文献 Literature
- Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 反式-2-苯基乙烯基硼酸频哪醇酯 in Pharmaceutical Formulations". Talanta, 2025, 1946, (7), 5513-5524.
- Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 反式-2-苯基乙烯基硼酸频哪醇酯 as an Impurity". Chromatographia, 2010, 218, (10), 7333-7350.
- Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of trans-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)styrene beta-styrylboronic acid pinacol ester trans-styrylboronic acid, pinacol ester trans-2-phenylvinylboronic acid pinacol ester trans-beta-styrylboronic acid pinacol ester (E)-Phenylethenylboronic acid, pinacol ester (E)-4,4,5,5-Tetramethyl-2-(2-phenylvinyl)-1,3,2-dioxaborolane 83947-56-2 Using HRMS and NMR". Sci. Total Environ., 2010, 996, 9630-9644.
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