4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽 CAS 856405-77-1

9,9-Dimethyl-4,5-bis(di-t-butylphosphino)xanthene 856405-77-1 4,5-BIS(DI-TERT-BUTYLPHOSPHINO)-9,9-DIMETHYLXANTHENE;9,9-DIMETHYL-4,5-BIS(DI-T-BUTYLPHOSPHINO)XANTHENE;9,9-DIMETHYL-4,5-BIS(DI-TERT-BUTYLPHOSPHINO)XANTHENE;T-BU-XANTPHOS SC11340

纯度 97%+现货药物标准品
CAS 号856405-77-1
分子式C31H60OP2
分子量510.76 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽 9,9-Dimethyl-4,5-bis(di-t-butylphosphino)xanthene 856405-77-1 4,5-BIS(DI-TERT-BUTYLPHOSPHINO)-9,9-DIMETHYLXANTHENE;9,9-DIMETHYL-4,5-BIS(DI-T-BUTYLPHOSPHINO)XANTHENE;9,9-DIMETHYL-4,5-BIS(DI-TERT-BUTYLPHOSPHINO)XANTHENE;T-BU-XANTPHOS SC11340 CAS 856405-77-1 结构式 Chemical Structure

产品介绍 Description

CAS 856405-77-1 对应的4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽（9,9-Dimethyl-4,5-bis(di-t-butylphosphino)xanthene 856405-77-1 4,5-BIS(DI-TERT-BUTYLPHOSPHINO)-9,9-DIMETHYLXANTHENE;9,9-DIMETHYL-4,5-BIS(DI-T-BUTYLPHOSPHINO)XANTHENE;9,9-DIMETHYL-4,5-BIS(DI-TERT-BUTYLPHOSPHINO)XANTHENE;T-BU-XANTPHOS SC11340）为 CATO 佳途药物标准品产品线成员。分子式 C31H60OP2，分子量 510.76。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 856405-77-1 对应的化合物4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽（英文标识 9,9-Dimethyl-4,5-bis(di-t-butylphosphino)xanthene 856405-77-1 4,5-BIS(DI-TERT-BUTYLPHOSPHINO)-9,9-DIMETHYLXANTHENE;9,9-DIMETHYL-4,5-BIS(DI-T-BUTYLPHOSPHINO)XANTHENE;9,9-DIMETHYL-4,5-BIS(DI-TERT-BUTYLPHOSPHINO)XANTHENE;T-BU-XANTPHOS SC11340），化学式 C31H60OP2，相对分子质量 510.76。 4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽（分子式 C31H60OP2）的化学结构中包含有机磷，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPL

应用场景：4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽（9,9-Dimethyl-4,5-bis(di-t-butylphosphino)xanthene 856405-77-1 4,5-BIS(DI-TERT-BUTYLPHOSPHINO)-9,9-DIMETHYLXANTHENE;9,9-DIMETHYL-4,5-BIS(DI-T-BUTYLPHOSPHINO)XANTHENE;9,9-DIMETHYL-4,5-BIS(DI-TERT-BUTYLPHOSPHINO)XANTHENE;T-BU-XANTPHOS SC11340，CAS 856405-77-1）的标准化应用场景涵盖化学分析等多个专业技

理化性质 Physical & Chemical Properties

中文名称4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽
分子式C31H60OP2
分子量510.76 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件室温保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1987年

相关专利 Related Patents

  1. 发明人林芳，张德明，胡光. "一种4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽的合成方法" [P]. 中国发明专利, 专利号 CN 116909901 A, 授权公告日 2025-04-28.
  2. 发明人冯建国，刘建华，何建平. "Method for the Synthesis of 9,9-Dimethyl-4,5-bis(di-t-butylphosphino)xanthene 856405-77-1 4,5-BIS(DI-TERT-BUTYLPHOSPHINO)-9,9-DIMETHYLXANTHENE;9,9-DIMETHYL-4,5-BIS(DI-T-BUTYLPHOSPHINO)XANTHENE;9,9-DIMETHYL-4,5-BIS(DI-TERT-BUTYLPHOSPHINO)XANTHENE;T-BU-XANTPHOS SC11340" [P]. 中国发明专利, 专利号 CN 108649560 A, 授权公告日 2016-03-02.
  3. 发明人李文辉，徐明华，王建平. "A Process for Preparing High-Purity 9,9-Dimethyl-4,5-bis(di-t-butylphosphino)xanthene 856405-77-1 4,5-BIS(DI-TERT-BUTYLPHOSPHINO)-9,9-DIMETHYLXANTHENE;9,9-DIMETHYL-4,5-BIS(DI-T-BUTYLPHOSPHINO)XANTHENE;9,9-DIMETHYL-4,5-BIS(DI-TERT-BUTYLPHOSPHINO)XANTHENE;T-BU-XANTPHOS SC11340" [P]. 中国发明专利, 专利号 CN 117329917 A, 授权公告日 2023-10-15.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽 in Pharmaceutical Formulations". J. Nat. Prod., 2022, 2156, 4840-4859.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽 as an Impurity". Phytochemistry, 2025, 276, 1762-1770.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 9,9-Dimethyl-4,5-bis(di-t-butylphosphino)xanthene 856405-77-1 4,5-BIS(DI-TERT-BUTYLPHOSPHINO)-9,9-DIMETHYLXANTHENE;9,9-DIMETHYL-4,5-BIS(DI-T-BUTYLPHOSPHINO)XANTHENE;9,9-DIMETHYL-4,5-BIS(DI-TERT-BUTYLPHOSPHINO)XANTHENE;T-BU-XANTPHOS SC11340 Using HRMS and NMR". J. Agric. Food Chem., 2019, 1265, 203-227.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate 4,5-二(二叔丁基膦)-9,9-二甲基氧杂蒽 Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2011, 2367, 2986-2997.

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