3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid CAS 877825-70-2

3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid

纯度 97%+现货药物标准品
CAS 号877825-70-2
分子式C16H14N2O3S
分子量314.36 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid 3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid CAS 877825-70-2 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid（3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid）为药物标准品，CAS 登记号 877825-70-2，分子式 C16H14N2O3S，分子量 314.36。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

在质量保证方面，3-5-(4-methylphenyl)-4-oxothieno2,3-dpyrimidin-3(4H)-ylpropanoic acid的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C16H14N2O3S 的3-5-(4-methylphenyl)-4-oxothieno2,3-dpyrimidin-3(4H)-ylpropanoic acid（3-5-(4-methylphenyl)-4-oxothieno2,3-dpyrimidin-3(4H)-ylpropanoic acid），其CAS登记号是 877825-70-2，分子量为 314.36 g/mol。 受分子结构中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键的影响，3-5-(4-methylphenyl)-4-oxothieno2,3-dpyr

应用场景：3- 5-(4-methylphenyl)-4-oxothieno 2,3-d pyrimidin-3(4H)-yl propanoic acid（3- 5-(4-methylphenyl)-4-oxothieno 2,3-d pyrimidin-3(4H)-yl propanoic acid，CAS 877825-70-2）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3- 5-(4-methylphenyl)-4-oxothieno 2,3-d pyrimidin-3(4H)-yl propanoic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇

理化性质 Physical & Chemical Properties

中文名称3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid
分子式C16H14N2O3S
分子量314.36 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. 发明人赵玉洁，胡光，刘建华. "一种3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid的合成方法" [P]. 中国发明专利, 专利号 CN 117091559 B, 授权公告日 2025-02-04.
  2. Anderson J P, Park J H, Mueller T. "Method for the Synthesis of 3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid" [P]. US Patent, US 10199824 B2, 2022-04-11.
  3. Martínez F, Björnsson E, Lefèvre J P. "A Process for Preparing High-Purity 3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid" [P]. European Patent, EP 3268785 A1, 2015-11-09.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid in Pharmaceutical Formulations". Food Chem., 2022, 1280, (9), 7111-7132.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid as an Impurity". Biomed. Chromatogr., 2016, 324, 5506-5519.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid Using HRMS and NMR". Sci. Total Environ., 2025, 2229, 9101-9106.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate 3-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl]propanoic acid Profile in Drug Substances According to ICH Guidelines". Molecules, 2013, 739, (6), 4798-4822.

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