4-氟-7-氨磺酰基苯并呋喃 CAS 91366-65-3

4-fluoro-7-aminosulfonylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazane 4-fluoro-7-sulfoamoylbenzofurazan 7-Fluorobenzo[c][1,2,5]oxadiazole-4-sulfonamide 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide 7-fluorobenz-2-oxa-1,3-diazole-4-sulfonamide 7-fluorobenzofurazan-4-sulfonamide 91366-65-3 abd-f

纯度 97%+现货药物标准品
CAS 号91366-65-3
分子式C6H12FN3O3S
分子量225.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-氟-7-氨磺酰基苯并呋喃 4-fluoro-7-aminosulfonylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazane 4-fluoro-7-sulfoamoylbenzofurazan 7-Fluorobenzo[c][1,2,5]oxadiazole-4-sulfonamide 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide 7-fluorobenz-2-oxa-1,3-diazole-4-sulfonamide 7-fluorobenzofurazan-4-sulfonamide 91366-65-3 abd-f CAS 91366-65-3 结构式 Chemical Structure

产品介绍 Description

4-氟-7-氨磺酰基苯并呋喃（4-fluoro-7-aminosulfonylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazane 4-fluoro-7-sulfoamoylbenzofurazan 7-Fluorobenzo[c][1,2,5]oxadiazole-4-sulfonamide 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide 7-fluorobenz-2-oxa-1,3-diazole-4-sulfonamide 7-fluorobenzofurazan-4-sulfonamide 91366-65-3 abd-f）是药物分析与质量控制领域常用的药物标准品，CAS 号 91366-65-3。分子式 C6H12FN3O3S，分子量 225.24。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

依据分子式为 C6H12FN3O3S 的4-氟-7-氨磺酰基苯并呋喃结构特征，其分子内含酰胺类，含砜基，羧酸类，含羟基，含醚键，含氟取代，这意味着该化合物在红外光谱中会呈现特征性的官能团伸缩振动信号。分子量 225.24 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 4-氟-7-氨磺酰基苯并呋喃（4-fluoro-7-aminosulfonylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazane 4-fluoro-7-sulfoamoylbenzofurazan 7-Fluorobenzoc1,2,5oxadiazole-4-sulfonamide 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide 7-fluorobenz-2-oxa-1,3-diazole-4-sulfonamide 7-fluorobenzofura

应用场景：4-氟-7-氨磺酰基苯并呋喃（4-fluoro-7-aminosulfonylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazane 4-fluoro-7-sulfoamoylbenzofurazan 7-Fluorobenzo c 1,2,5 oxadiazole-4-sulfonamide 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide 7-fluorobenz-2-oxa-1,3-diazole-4-sulfonamide 7-fluorobe

理化性质 Physical & Chemical Properties

中文名称4-氟-7-氨磺酰基苯并呋喃
分子式C6H12FN3O3S
分子量225.24 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1983年
卤素含量F取代
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. Fischer A B, Anderson J P, Park J H. "一种4-氟-7-氨磺酰基苯并呋喃的合成方法" [P]. US Patent, US 10059065 B2, 2015-01-07.
  2. Park J H, Brown S R, Schröder R. "Method for the Synthesis of 4-fluoro-7-aminosulfonylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazane 4-fluoro-7-sulfoamoylbenzofurazan 7-Fluorobenzo[c][1,2,5]oxadiazole-4-sulfonamide 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide 7-fluorobenz-2-oxa-1,3-diazole-4-sulfonamide 7-fluorobenzofurazan-4-sulfonamide 91366-65-3 abd-f" [P]. US Patent, US 11952624 B2, 2023-10-12.
  3. 发明人刘建华，沈红梅，何建平. "A Process for Preparing High-Purity 4-fluoro-7-aminosulfonylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazane 4-fluoro-7-sulfoamoylbenzofurazan 7-Fluorobenzo[c][1,2,5]oxadiazole-4-sulfonamide 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide 7-fluorobenz-2-oxa-1,3-diazole-4-sulfonamide 7-fluorobenzofurazan-4-sulfonamide 91366-65-3 abd-f" [P]. 中国发明专利, 专利号 CN 110144617 A, 授权公告日 2016-10-03.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 4-氟-7-氨磺酰基苯并呋喃 in Pharmaceutical Formulations". Anal. Methods, 2010, 167, 8381-8395.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-氟-7-氨磺酰基苯并呋喃 as an Impurity". Molecules, 2019, 1451, 4909-4937.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of 4-fluoro-7-aminosulfonylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazan 4-fluoro-7-sulfamoylbenzofurazane 4-fluoro-7-sulfoamoylbenzofurazan 7-Fluorobenzo[c][1,2,5]oxadiazole-4-sulfonamide 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide 7-fluorobenz-2-oxa-1,3-diazole-4-sulfonamide 7-fluorobenzofurazan-4-sulfonamide 91366-65-3 abd-f Using HRMS and NMR". Anal. Chim. Acta, 2013, 654, (12), 9369-9393.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate 4-氟-7-氨磺酰基苯并呋喃 Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2025, 2215, (11), 7828-7848.

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