3′-唾液酸-Lewis-a 四糖 CAS 92448-22-1

3'-SLea 3'-Sialyl Lewis A 92448-22-1 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>3)-O-[6-deoxy-a-L-galactopyranosyl-(1>4)]-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2->3)-O-beta-D-galactopyranosyl-(1->3)-O-[6-deoxy-alpha-L-galactopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy- SLea Sialyl Lea tri Sialyl Lewis a Sialyl-Lewis a a-NeuNAc-(2>3)-b-D-Gal-(1>3)-(a-L-Fuc-[1>4])-D-GlcNAc

纯度 97%+现货药物标准品

CAS 号	92448-22-1
分子式	C31H52N2O23
分子量	820.74 g/mol
分类	药物标准品 / 原料药标准品
库存状态	现货

化学结构式 Structure

3′-唾液酸-Lewis-a 四糖 3'-SLea
3'-Sialyl Lewis A
92448-22-1
D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>3)-O-[6-deoxy-a-L-galactopyranosyl-(1>4)]-2-(acetylamino)-2-deoxy- (9CI)
D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2->3)-O-beta-D-galactopyranosyl-(1->3)-O-[6-deoxy-alpha-L-galactopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy-
SLea
Sialyl Lea tri
Sialyl Lewis a
Sialyl-Lewis a
a-NeuNAc-(2>3)-b-D-Gal-(1>3)-(a-L-Fuc-[1>4])-D-GlcNAc CAS 92448-22-1 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3′-唾液酸-Lewis-a 四糖（3'-SLea 3'-Sialyl Lewis A 92448-22-1 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>3)-O-[6-deoxy-a-L-galactopyranosyl-(1>4)]-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2->3)-O-beta-D-galactopyranosyl-(1->3)-O-[6-deoxy-alpha-L-galactopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy- SLea Sialyl Lea tri Sialyl Lewis a Sialyl-Lewis a a-NeuNAc-(2>3)-b-D-Gal-(1>3)-(a-L-Fuc-[1>4])-D-GlcNAc，CAS 92448-22-1），分子式 C31H52N2O23，分子量 820.74。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，3′-唾液酸-Lewis-a 四糖的分子量为820.74 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 3′-唾液酸-Lewis-a 四糖（3'-SLea 3'-Sialyl Lewis A 92448-22-1 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>3)-O-6-deoxy-a-L-galactopyranosyl-(1>4)-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2->3)-O-beta-D-galactopyranosyl-(1->3)-O-6-deoxy-alpha-L-galactopyranosyl-(1->4)-2-(acetylamino)-2-deoxy- SLea Sialyl Lea tri Sialyl Le

应用场景：在化学分析实验室中，3′-唾液酸-Lewis-a 四糖（CAS 92448-22-1）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。推荐以3′-唾液酸-Lewis-a 四糖配制标准系列工作溶液，用于建立标准曲线实现外标法定量。建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干

理化性质 Physical & Chemical Properties

中文名称	3′-唾液酸-Lewis-a 四糖
分子式	C31H52N2O23
分子量	820.74 g/mol
外观形态	类白色至淡黄色无定形粉末
纯度	97%+
储存条件	阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考	可溶于DMSO、DMF、甲醇
稳定性	空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型	药物标准品
子类	原料药标准品
不饱和度（DBE）	7.0
UV特征	有紫外吸收
结构特征	含芳环
CAS登记年份（估）	1983年
含氮原子数	2

参考文献 Literature

Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 3′-唾液酸-Lewis-a 四糖 in Pharmaceutical Formulations". Phytochemistry, 2024, 1768, 9237-9249.
Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3′-唾液酸-Lewis-a 四糖 as an Impurity". Anal. Methods, 2021, 1615, (10), 315-340.
Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 3'-SLea 3'-Sialyl Lewis A 92448-22-1 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>3)-O-[6-deoxy-a-L-galactopyranosyl-(1>4)]-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2->3)-O-beta-D-galactopyranosyl-(1->3)-O-[6-deoxy-alpha-L-galactopyranosyl-(1->4)]-2-(acetylamino)-2-deoxy- SLea Sialyl Lea tri Sialyl Lewis a Sialyl-Lewis a a-NeuNAc-(2>3)-b-D-Gal-(1>3)-(a-L-Fuc-[1>4])-D-GlcNAc Using HRMS and NMR". Chromatographia, 2017, 160, (7), 2518-2524.

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