3′-唾液酸-Lewis-X 四糖 CAS 98603-84-0
3'-SLeX 3'-Sialyl-Lewis X 3'-Sialyl-Lewis-X tetrasaccharide 98603-84-0 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>4)-O-[6-deoxy-a-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2>3)-O-beta-D-galactopyranosyl-(1>4)-O-[6-deoxy-alpha-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- SLex SSEA 1 Sialyl Lex tri Sialyl-Lewis X a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc
| CAS 号 | 98603-84-0 |
| 分子式 | C31H52N2O23 |
| 分子量 | 820.74 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 98603-84-0 对应的3′-唾液酸-Lewis-X 四糖（3'-SLeX 3'-Sialyl-Lewis X 3'-Sialyl-Lewis-X tetrasaccharide 98603-84-0 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>4)-O-[6-deoxy-a-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2>3)-O-beta-D-galactopyranosyl-(1>4)-O-[6-deoxy-alpha-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- SLex SSEA 1 Sialyl Lex tri Sialyl-Lewis X a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc）为 CATO 佳途药物标准品产品线成员。分子式 C31H52N2O23，分子量 820.74。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括3′-唾液酸-Lewis-X 四糖在内的目标物的控制。 化学式为 C31H52N2O23 的3′-唾液酸-Lewis-X 四糖（3'-SLeX 3'-Sialyl-Lewis X 3'-Sialyl-Lewis-X tetrasaccharide 98603-84-0 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>4)-O-6-deoxy-a-L-galactopyranosyl-(1>3)-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2>3)-O-beta-D-galactopyranosyl-(1>4)-O-6-deoxy-alpha-L-galactopyranosyl-(1>3)-2-(acetylamino)-2-deox
应用场景：从实际应用出发，3′-唾液酸-Lewis-X 四糖（CAS 98603-84-0）在化学分析中作为关键的基准对照物质。 推荐以3′-唾液酸-Lewis-X 四糖配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮
理化性质 Physical & Chemical Properties
| 中文名称 | 3′-唾液酸-Lewis-X 四糖 |
| 分子式 | C31H52N2O23 |
| 分子量 | 820.74 g/mol |
| 外观形态 | 类白色至淡黄色无定形粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 7.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1985年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人何建平，陈志强，黄志刚. "一种3′-唾液酸-Lewis-X 四糖的合成方法" [P]. 中国发明专利, 专利号 CN 113659138 B, 授权公告日 2025-05-02.
- 发明人赵玉洁，黄志刚，杨光. "Method for the Synthesis of 3'-SLeX 3'-Sialyl-Lewis X 3'-Sialyl-Lewis-X tetrasaccharide 98603-84-0 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>4)-O-[6-deoxy-a-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2>3)-O-beta-D-galactopyranosyl-(1>4)-O-[6-deoxy-alpha-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- SLex SSEA 1 Sialyl Lex tri Sialyl-Lewis X a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc" [P]. 中国发明专利, 专利号 CN 115296994 A, 授权公告日 2024-01-13.
- 发明人周伟，杨光，张德明. "A Process for Preparing High-Purity 3'-SLeX 3'-Sialyl-Lewis X 3'-Sialyl-Lewis-X tetrasaccharide 98603-84-0 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>4)-O-[6-deoxy-a-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2>3)-O-beta-D-galactopyranosyl-(1>4)-O-[6-deoxy-alpha-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- SLex SSEA 1 Sialyl Lex tri Sialyl-Lewis X a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc" [P]. 中国发明专利, 专利号 CN 109050348 A, 授权公告日 2022-03-23.
参考文献 Literature
- Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 3′-唾液酸-Lewis-X 四糖 in Pharmaceutical Formulations". J. Nat. Prod., 2012, 842, (10), 323-347.
- Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3′-唾液酸-Lewis-X 四糖 as an Impurity". Sci. Total Environ., 2020, 1202, 6907-6935.
- Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 3'-SLeX 3'-Sialyl-Lewis X 3'-Sialyl-Lewis-X tetrasaccharide 98603-84-0 D-Glucose, O-(N-acetyl-a-neuraminosyl)-(2>3)-O-b-D-galactopyranosyl-(1>4)-O-[6-deoxy-a-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- (9CI) D-glucose, O-5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranonosyl-(2>3)-O-beta-D-galactopyranosyl-(1>4)-O-[6-deoxy-alpha-L-galactopyranosyl-(1>3)]-2-(acetylamino)-2-deoxy- SLex SSEA 1 Sialyl Lex tri Sialyl-Lewis X a-NeuNAc-(2>3)-b-D-Gal-(1>4)(a-L-Fuc-[1>3])-D-GlcNAc Using HRMS and NMR". Phytochemistry, 2010, 1385, (3), 2576-2583.
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