1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione CAS 929975-78-0

1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione

纯度 97%+现货药物标准品
CAS 号929975-78-0
分子式C12H18N4O2
分子量250.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione CAS 929975-78-0 结构式 Chemical Structure

产品介绍 Description

1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione（英文名 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione，CAS 929975-78-0）属于药物标准品。分子式 C12H18N4O2，分子量 250.30。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione在内的目标物的控制。 CAS编号 929975-78-0 对应的化合物1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione（英文标识 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione），化学式 C12H18N4O2，相对分子质量 250.30。 从化学结构特征来看，1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione的分子骨架中包含氨基酸衍生物，酰胺类，含羟基，含醚键。该化合物的不饱和度为6.0，表明结构中存在约6个环或双键等价

应用场景：从实际应用出发，1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione（CAS 929975-78-0）在化学分析中作为关键的基准对照物质。 推荐以1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干

理化性质 Physical & Chemical Properties

中文名称1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione
分子式C12H18N4O2
分子量250.30 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数4

相关专利 Related Patents

  1. 发明人刘建华，何建平，马晓峰. "一种1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione的合成方法" [P]. 中国发明专利, 专利号 CN 116796269 B, 授权公告日 2025-12-15.
  2. 发明人赵玉洁，唐晓军，马晓峰. "Method for the Synthesis of 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione" [P]. 中国发明专利, 专利号 CN 117523181 A, 授权公告日 2016-08-05.
  3. 发明人王建平，林芳，郭海燕. "A Process for Preparing High-Purity 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione" [P]. 中国发明专利, 专利号 CN 115495608 B, 授权公告日 2019-03-13.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione in Pharmaceutical Formulations". Talanta, 2024, 1265, (12), 9446-9455.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione as an Impurity". J. Nat. Prod., 2021, 799, 7143-7146.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione Using HRMS and NMR". Molecules, 2021, 1670, (2), 3756-3778.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 1,3-dimethyl-6-(3,4,5,6-tetrahydro-2H-azepin-7-ylamino)pyrimidine-2,4(1H,3H)-dione Profile in Drug Substances According to ICH Guidelines". Food Chem., 2023, 1219, (1), 471-476.

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