6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione CAS 945008-17-3

6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione

纯度 97%+现货药物标准品
CAS 号945008-17-3
分子式C21H17N5O3
分子量387.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione 6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione CAS 945008-17-3 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione（6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione，CAS 945008-17-3），分子式 C21H17N5O3，分子量 387.39。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

作为认证标准物质（CRM），6-amino-1,3-dimethyl-5-{2-(pyridin-2-yl)quinolin-4-ylcarbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C21H17N5O3 的6-amino-1,3-dimethyl-5-{2-(pyridin-2-yl)quinolin-4-ylcarbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione（6-amino-1,3-dimethyl-5-{2-(pyridin-2-yl)quinolin-4-ylcarbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione），其CAS登记号是 945008-17-3，分子量为 387.39 g/mol。 6-amino-1,3-dimethyl

应用场景：从实际应用出发，6-amino-1,3-dimethyl-5-{ 2-(pyridin-2-yl)quinolin-4-yl carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione（CAS 945008-17-3）在化学分析中作为关键的基准对照物质。 推荐以6-amino-1,3-dimethyl-5-{ 2-(pyridin-2-yl)quinolin-4-yl carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配

理化性质 Physical & Chemical Properties

中文名称6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione
分子式C21H17N5O3
分子量387.39 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）16.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数5

相关专利 Related Patents

  1. 发明人马晓峰，钱学锋，朱建伟. "一种6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione的合成方法" [P]. 中国发明专利, 专利号 CN 113555594 A, 授权公告日 2021-12-27.
  2. Thompson G K, Williams B T, Johnson M A. "Method for the Synthesis of 6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione" [P]. US Patent, US 11851372 B2, 2020-02-24.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione in Pharmaceutical Formulations". Sci. Total Environ., 2010, 943, (6), 567-584.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione as an Impurity". J. Nat. Prod., 2010, 339, 8750-8762.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 6-amino-1,3-dimethyl-5-{[2-(pyridin-2-yl)quinolin-4-yl]carbonyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione Using HRMS and NMR". Biomed. Chromatogr., 2010, 1756, (11), 9727-9745.

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