2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride CAS 1315366-83-6

2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride

纯度 97%+现货药物标准品
CAS 号1315366-83-6
分子式C14H14F3N3 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride 2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride CAS 1315366-83-6 结构式 Chemical Structure

产品介绍 Description

CAS 1315366-83-6 对应的2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride（2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C14H14F3N3 2*HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，2-(pyrrolidin-2-yl)-4-3-(trifluoromethyl)phenyl-1H-imidazole dihydrochloride的分子量为317.74 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1315366-83-6 对应的化合物2-(pyrrolidin-2-yl)-4-3-(trifluoromethyl)phenyl-1H-imidazole dihydrochloride（英文标识 2-(pyrrolidin-2-yl)-4-3-(trifluoromethyl)phenyl-1H-imidazole dihydrochloride），化学式 C14H14F3N3 2HCl，相对分子质量 317.74。 依据分子式为 C14H14F3N3 2HCl 的2-(pyrrolidin-2-yl)-4-3-(trifluoromethyl)phenyl-1H-imidazole dihydrochloride结构特征，其分子内含含氮杂环结构，含氰基，含氟/氯取代，这意味着该化

应用场景：针对化学分析用途，2-(pyrrolidin-2-yl)-4- 3-(trifluoromethyl)phenyl -1H-imidazole dihydrochloride（2-(pyrrolidin-2-yl)-4- 3-(trifluoromethyl)phenyl -1H-imidazole dihydrochloride）是具有明确定量溯源的认证级对照品。 推荐以2-(pyrrolidin-2-yl)-4- 3-(trifluoromethyl)phenyl -1H-imidazole dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙

理化性质 Physical & Chemical Properties

中文名称2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride
分子式C14H14F3N3 2*HCl
分子量317.74 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
卤素含量F/Cl取代
含氮原子数3

相关专利 Related Patents

  1. Lefèvre J P, Björnsson E, Schröder R. "一种2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride的合成方法" [P]. European Patent, EP 3050679 A1, 2025-02-18.
  2. Klinger H, Hughes D C, Yamamoto T. "Method for the Synthesis of 2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride" [P]. US Patent, US 10981490 B2, 2023-05-04.
  3. 发明人刘建华，高志强，冯建国. "A Process for Preparing High-Purity 2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride" [P]. 中国发明专利, 专利号 CN 111894218 B, 授权公告日 2025-10-27.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride in Pharmaceutical Formulations". Chemosphere, 2023, 225, 8060-8079.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride as an Impurity". Food Chem., 2015, 1408, (1), 1865-1870.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride Using HRMS and NMR". J. Sep. Sci., 2023, 772, 7993-8014.
  4. Martinez C, Lopez D R. "Forced Degradation Studies to Evaluate 2-(pyrrolidin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1H-imidazole dihydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2017, 516, 2252-2275.

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